Revefenacin Disease Interactions

Revefenacin should be used with caution in patients with narrow-angle glaucoma. Prescribers and patients should be alert for signs and symptoms of acute narrow-angle glaucoma (e.g. eye pain or discomfort, blurred vision, visual halos or colored images in association with red eyes from conjunctival congestion and corneal edema). Instruct patients to consult a physician immediately if any of these signs or symptoms develops.

The systemic exposure of revefenacin is unchanged while that of its active metabolite is increased in subjects with moderate hepatic impairment. The safety of revefenacin has not been evaluated in COPD patients with mild-to-severe hepatic impairment, therefore revefenacin is not recommended in patients with any degree of hepatic impairment.

No dosage adjustment is required in patients with renal impairment, however, patients with severe renal impairment should be monitored for systemic antimuscarinic side effects.

Revefenacin should be used with caution in patients with urinary retention. Health care providers and patients should be alert for signs and symptoms of urinary retention (e.g. difficulty passing urine, painful urination), especially in patients with prostatic hyperplasia or bladder neck obstruction. Instruct patients to consult a healthcare provider immediately if any of these signs or symptoms develops.