Skip to Content

Diprivan (propofol) Disease Interactions

There are 5 disease interactions with Diprivan (propofol):

Major

Propofol (Includes Diprivan) ↔ Cardiovascular Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Cerebral Vascular Disorder, Intracranial Hypertension, Hypotension, Heart Block, Ischemic Heart Disease

Propofol can induce severe hypotension and/or cardiovascular depression, particularly during the induction phase of sedation or anesthesia. Therapy with propofol should be administered cautiously in patients with cardiovascular disorders including hemodynamic impairment, increased intracranial pressure, or impaired cerebral circulation.

References

  1. Warden JC, Pickford DR "Fatal cardiovascular collapse following propofol induction in high-risk patients and dilemmas in the selection of a short-acting induction agent." Anaesth Intensive Care 23 (1995): 485-7
  2. Deutschman CS, Harris AP, Fleisher LA "Changes in heart rate variability under propofol anesthesia: a possible explanation for propofol-induced bradycardia." Anesth Analg 79 (1994): 373-7
  3. "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
View all 4 references
Moderate

Propofol (Includes Diprivan) ↔ Hyperlipidemia

Moderate Potential Hazard, High plausibility

Applies to: Hyperlipidemia

Propofol is formulated in an oil-and-water emulsion and elevated triglycerides can occur during extended therapy. Propofol should be administered cautiously in patients with lipid disorders such as primary hyperlipoproteinemia, diabetic hyperlipemia, and pancreatitis. Each milliliter of propofol contains 0.1g of fat (1.1 kcal).

References

  1. "Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
  2. Mateu J, Barrachina F "Hypertriglyceridaemia associated with propofol sedation in critically ill patients." Intensive Care Med 22 (1996): 834-5
Moderate

Propofol (Includes Diprivan) ↔ Renal Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

At high doses (2-3 grams per day), EDTA has been reported, on rare occasions, to be toxic to the renal tubules. Studies to-date, in patients with normal or impaired renal function have not shown any alteration in renal function with propofol Injectable Emulsion containing 0.005% disodium edetate. In patients at risk for renal impairment, urinalysis and urine sediment should be checked before initiation of sedation and then be monitored on alternate days during sedation.

Moderate

Propofol (Includes Diprivan) ↔ Seizure

Moderate Potential Hazard, Moderate plausibility

Applies to: Seizures

Patients with seizure disorders are at increased risk of seizure activity during the recovery phase of sedation or anesthesia following administration of propofol. Clinical monitoring of seizure activity is recommended in patients with or predisposed to seizure disorders.

References

  1. Samra SK, Sneyd JR, Ross DA, Henry TR "Effects of propofol sedation on seizures and intracranially recorded epileptiform activity in patients with partial epilepsy." Anesthesiology 82 (1995): 843-51
  2. Cochran D, Price W, Gwinnutt CL "Unilateral convulsion after induction of anaesthesia with propofol." Br J Anaesth 76 (1996): 570-2
  3. Sutherland MJ, Burt P "Propofol and seizures." Anaesth Intensive Care 22 (1994): 733-7
View all 6 references
Moderate

Propofol (Includes Diprivan) ↔ Zinc Deficiency

Moderate Potential Hazard, Moderate plausibility

Applies to: Zinc Deficiency, Diarrhea, Sepsis, Burns - External

Reports of mean urinary zinc loss during propofol therapy was approximately 2.5 to 3.0 mg/day in adult patients and 1.5 to 2.0 mg/day in pediatric patients. Practitioners should consider the administration of supplemental zinc during prolonged therapy with propofol in patients who are predisposed to zinc deficiency, such as those with burns, diarrhea, and/or major sepsis. Monitoring is recommended in these patients.

Diprivan (propofol) drug Interactions

There are 265 drug interactions with Diprivan (propofol)

Diprivan (propofol) alcohol/food Interactions

There are 2 alcohol/food interactions with Diprivan (propofol)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide