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Axid (nizatidine) Disease Interactions

There are 2 disease interactions with Axid (nizatidine):

Major

H2 Antagonists (Includes Axid) ↔ Gi Bleeding

Severe Potential Hazard, Moderate plausibility

Applies to: Gastrointestinal Hemorrhage

Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.

Moderate

Nizatidine (Includes Axid) ↔ Renal Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Nizatidine and its metabolites are primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min).

References

  1. "Product Information. Axid (nizatidine)." Lilly, Eli and Company, Indianapolis, IN.
  2. Aronoff GR, Bergstrom RF, Bopp RJ, Sloan RS, Callaghan JT "Nizatidine disposition in subjects with normal and impaired renal function." Clin Pharmacol Ther 43 (1988): 688-95
  3. Gladziwa U, Klotz U "Pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure." Clin Pharmacokinet 27 (1994): 393-408

Axid (nizatidine) drug Interactions

There are 150 drug interactions with Axid (nizatidine)

Axid (nizatidine) alcohol/food Interactions

There is 1 alcohol/food interaction with Axid (nizatidine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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