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Nesiritide Disease Interactions

There are 2 disease interactions with nesiritide:


Nesiritide (applies to nesiritide) hypotension

Major Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease

Nesiritide may cause hypotension and should be administered in settings where blood pressure can be monitored closely and hypotension can be aggressively treated. The use of nesiritide is not recommended in patients for whom vasodilation agents are not appropriate, such as patients with significant valvular stenosis, restrictive or obstructive cardiomyopathy, constrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent upon venous return. The use of nesiritide is contraindicated in patients with persistent systolic blood pressure below 100 mm Hg prior to therapy because of an increased risk of symptomatic hypotension, and in patients in cardiogenic shock.


Nesiritide (applies to nesiritide) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Nesiritide may decrease renal function as judged by increases in serum creatinine which should be monitored both during and after treatment has been completed, and until values have been stabilized. Use care when administering this agent to patients with renal impairment.

Nesiritide drug interactions

There are 66 drug interactions with nesiritide

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.