Synarel Disease Interactions
There are 4 disease interactions with Synarel (nafarelin).
Nafarelin nasal (applies to Synarel) abnormal vaginal bleeding
Major Potential Hazard, High plausibility. Applicable conditions: Abnormal Uterine Bleeding
The use of nafarelin nasal is contraindicated in patients with undiagnosed, abnormal vaginal bleeding. Patients should be evaluated to ensure that neoplastic lesions are not present.
Nafarelin (applies to Synarel) seizures
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Brain/Intracranial Tumor, Cerebral Vascular Disorder
Postmarketing reports of convulsions have been observed in patients receiving GnRH agonists. These have included patients with a history of seizures, epilepsy, cerebrovascular disorder, central nervous anomalies such as tumors, and patients receiving concomitant medications that have been associated with convulsions. Convulsions have also been reported in patients with none of these conditions. Caution is advised when administering nafarelin to patients with any of these conditions.
Nafarelin nasal (applies to Synarel) bone density loss
Moderate Potential Hazard, High plausibility. Applicable conditions: Osteoporosis, Alcoholism
Nafarelin induces a hypoestrogenic effect that results in a small loss in bone density. Therapy with nafarelin should be administered cautiously in patients with major risk factors for decreased bone mineral content, such as chronic alcohol and/or tobacco use, a strong family history of osteoporosis, or chronic use of drugs that can reduce bone mass (e.g., anticonvulsants, corticosteroids).
Nafarelin nasal (applies to Synarel) ovarian cysts
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Adrenal Tumor
Nafarelin therapy induces a release of pituitary gonadotropins (LH and FSH). Ovarian cysts or enlargement of existing ovarian cysts (primarily in women with polycystic ovarian disease) have been reported during the first months of treatment. Spontaneous resolution generally occurs in 4 to 6 weeks of therapy, but some cases require discontinuation of nafarelin therapy.
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Synarel drug interactions
There are 2 drug interactions with Synarel (nafarelin).
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- Drug class: gonadotropin releasing hormones
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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