Mupirocin topical Disease Interactions
There is 1 disease interaction with mupirocin topical:
Mupirocin topical (Includes mupirocin topical) ↔ polyethylene glycol
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction, Burns - External
Bactroban (brand of mupirocin) 2% ointment--but not the cream or the nasal ointment--is formulated in a polyethylene glycol base. Polyethylene glycol can be absorbed from open wounds and damaged skin, which is then excreted by the kidney where it may also produce serious toxicity. Bactroban 2% ointment should not be used in conditions where absorption of large quantities of polyethylene glycol might be expected (e.g., in severe burns), particularly if there is evidence of moderate or severe renal impairment.
- "Product Information. Bactroban (mupirocin)." SmithKline Beecham, Philadelphia, PA.
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- Drug class: topical antibiotics
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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