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Mupirocin topical Disease Interactions

There is 1 disease interaction with mupirocin topical.


Mupirocin topical (applies to mupirocin topical) polyethylene glycol

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Burns - External

Bactroban (brand of mupirocin) 2% ointment--but not the cream or the nasal ointment--is formulated in a polyethylene glycol base. Polyethylene glycol can be absorbed from open wounds and damaged skin, which is then excreted by the kidney where it may also produce serious toxicity. Bactroban 2% ointment should not be used in conditions where absorption of large quantities of polyethylene glycol might be expected (e.g., in severe burns), particularly if there is evidence of moderate or severe renal impairment.


  1. "Product Information. Bactroban (mupirocin topical)." Apothecon Inc (2022):

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.