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Skelaxin (metaxalone) Disease Interactions

There are 2 disease interactions with Skelaxin (metaxalone):


Metaxalone (Includes Skelaxin) ↔ Anemia

Severe Potential Hazard, Moderate plausibility

Applies to: Anemia

The manufacturer considers the use of metaxalone to be contraindicated in patients with or predisposed to drug-induced, hemolytic, or other anemias. Rare incidences of hemolytic anemia have been associated with the administration of metaxalone.


  1. "Product Information. Skelaxin (metaxalone)." Carnrick Laboratories Inc, Cedar Knolls, NJ.

Metaxalone (Includes Skelaxin) ↔ Renal/Liver Disease

Severe Potential Hazard, High plausibility

Applies to: Liver Disease, Renal Dysfunction

The manufacturer considers the use of metaxalone to be contraindicated in patients with severely impaired hepatic and/or renal function. Metaxalone is metabolized by the liver and subsequently eliminated by the kidney, thus both parent drug and metabolites may accumulate in such patients. Additionally, metaxalone may be hepatotoxic. Jaundice as well as abnormalities in liver function tests, including elevations in serum AST, ALT, alkaline phosphatase and bilirubin, have been reported. Nephrotoxicity and proteinuria have also occurred rarely. Therapy with metaxalone should be administered cautiously in patients with mild to moderate hepatic and/or renal impairment.


  1. "Product Information. Skelaxin (metaxalone)." Carnrick Laboratories Inc, Cedar Knolls, NJ.

Skelaxin (metaxalone) drug Interactions

There are 639 drug interactions with Skelaxin (metaxalone)

Skelaxin (metaxalone) alcohol/food Interactions

There is 1 alcohol/food interaction with Skelaxin (metaxalone)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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