Skip to main content

Mulpleta Disease Interactions

There are 2 disease interactions with Mulpleta (lusutrombopag).

Moderate

Lusutrombopag (applies to Mulpleta) severe renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Pharmacokinetics information in patients with severe renal impairment (CrCl less than 30 mL/min) is limited. Caution is advised if using in this patient population.

References

  1. (2018) "Product Information. Mulpleta (lusutrombopag)." Shionogi USA Inc
Moderate

TPO receptor agonists (applies to Mulpleta) thrombotic / thromboembolic complications

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Thrombotic/Thromboembolic Disorder, History - Thrombotic/Thromboembolic Disorder, Protein C Deficiency

Thromboembolic complications may result from increases in platelet counts with TPO receptor agonists such as avatrombopag, lusutrombopag, and eltrombopag. Consider the potential for increased risk of thromboembolism when administering these medications to patients with known risk factors for thromboembolism, including genetic prothrombotic conditions (Factor V Leiden, Prothrombin 20210 A, Antithrombin deficiency or Protein C or S deficiency).

References

  1. (2008) "Product Information. Promacta (eltrombopag)." GlaxoSmithKline
  2. (2018) "Product Information. Doptelet (avatrombopag)." Dova Pharmaceuticals
  3. (2018) "Product Information. Mulpleta (lusutrombopag)." Shionogi USA Inc

Mulpleta drug interactions

There are 148 drug interactions with Mulpleta (lusutrombopag).

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer