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Claritin (loratadine) Disease Interactions

There is 1 disease interaction with Claritin (loratadine):

Moderate

Loratadine (Includes Claritin) ↔ Renal/Liver Disease

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction, Liver Disease

Loratadine is primarily converted by the liver to an active metabolite, and both parent drug and metabolite are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from loratadine due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function (GFR < 30 mL/min). Due to the differential effects of hepatic impairment on the serum half-life and clearance of loratadine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of liver failure.

References

  1. Monroe EW "Safety and efficacy of loratadine in urticaria." Int J Dermatol 35 (1996): 837-41
  2. Matzke GR, Halstenson CE, Opsahl JA, Hilbert J, Perentesis G, Radwanski E, Zampaglione N "Pharmacokinetics of loratadine in patients with renal insufficiency." J Clin Pharmacol 30 (1990): 364-71
  3. Clissold SP, Sorkin EM, Goa KL "Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy." Drugs 37 (1989): 42-57
  4. Hilbert J, Moritzen V, Parks A, Radwanski E, Perentesis G, Symchowicz S, Zampaglione N "The pharmacokinetics of loratadine in normal geriatric volunteers." J Int Med Res 16 (1988): 50-60
  5. "Product Information. Claritin (loratadine)." Schering Laboratories, Kenilworth, NJ.
  6. Schiano TD, Bellary SV, Cassidy MJ, Thomas RM, Black M "Subfulminant liver failure and severe hepatotoxicity caused by loratadine use." Ann Intern Med 125 (1996): 738-40
View all 6 references

Claritin (loratadine) drug Interactions

There are 85 drug interactions with Claritin (loratadine)

Claritin (loratadine) alcohol/food Interactions

There is 1 alcohol/food interaction with Claritin (loratadine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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