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Linagliptin Disease Interactions

There is 1 disease interaction with linagliptin.


DPP-4 inhibitors (applies to linagliptin) pancreatitis

Major Potential Hazard, Low plausibility.

There have been postmarketing reports of acute pancreatitis in patients taking DPP-4 inhibitors. These drugs should be used with caution in patients with a history of pancreatitis or pancreatic disease, although it is unknown if they are at increased risk. Patients should be observed for signs and symptoms of pancreatitis during treatment. If pancreatitis is suspected, treatment should be discontinued immediately and appropriate management should be initiated.


  1. "Product Information. Januvia (sitagliptin)." Merck & Co., Inc (2006):
  2. "Product Information. Onglyza (saxagliptin)." Bristol-Myers Squibb (2009):
  3. "Product Information. Tradjenta (linagliptin)." Boehringer Ingelheim (2011):
  4. "Product Information. Nesina (alogliptin)." Takeda Pharmaceuticals America (2013):
View all 4 references

Linagliptin drug interactions

There are 325 drug interactions with linagliptin.

Linagliptin alcohol/food interactions

There is 1 alcohol/food interaction with linagliptin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.