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Lenvima (lenvatinib) Disease Interactions

There are 14 disease interactions with Lenvima (lenvatinib):

Moderate

Lenvatinib (applies to Lenvima) arterial thromboembolism

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Thrombotic/Thromboembolic Disorder, History - Thrombotic/Thromboembolic Disorder

In clinical trials, arterial thromboembolic events were reported in patients treated with lenvatinib. It is recommended to discontinue lenvatinib following an arterial thrombotic event. Care should be exercised when resuming lenvatinib after an arterial thromboembolic event as its safety has not been established and its use has not been studied in patients who have had an arterial thromboembolic event within the previous 6 months.

Moderate

Lenvatinib (applies to Lenvima) bleeding

Moderate Potential Hazard, Moderate plausibility.

Hemorrhagic events, including fatal hemorrhagic events have been reported with the use of lenvatinib. It is recommended to withhold treatment and to either resume at a reduced dose or discontinue treatment depending on the severity and persistence of hemorrhage. Discontinue therapy in patients who experience severe or fatal hemorrhagic events. Prior to initiating treatment, consider the risk of severe or fatal hemorrhage associated with tumor invasion/infiltration of major blood vessels (e.g. carotid artery).

Moderate

Lenvatinib (applies to Lenvima) cardiac dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease, Pulmonary Edema

Cardiac dysfunctions, defined as decreased left or right ventricular function, cardiac failure, or pulmonary edema have been reported with the use of lenvatinib. It is recommended to monitor patients for clinical symptoms or signs of cardiac decompensation. Withhold lenvatinib therapy for development of Grade 3 cardiac dysfunction until improved and either resume at a reduced dose or discontinue its use depending on the severity and persistence of cardiac dysfunction. Discontinue lenvatinib for Grade 4 cardiac dysfunction.

Moderate

Lenvatinib (applies to Lenvima) diarrhea

Moderate Potential Hazard, Moderate plausibility.

Cases of diarrhea have been reported with the use of lenvatinib, sometimes leading to interruption of therapy. It is recommended to initiate prompt medical management for the development of diarrhea and to monitor for dehydration. It might be necessary to interrupt treatment with lenvatinib or resume at a reduced dose or permanently discontinue treatment with lenvatinib if severe or fatal diarrhea persists despite medical management. Care and close monitoring is recommended when using this agent in patients presenting diarrhea or at risk of developing diarrhea.

Moderate

Lenvatinib (applies to Lenvima) GI perforation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Perforation

Cases of gastrointestinal perforation or fistula have been reported with the use of lenvatinib. Discontinue the use of lenvatinib in patients who develop gastrointestinal perforation or life-threatening fistula. Close monitoring should be exercised when using this agent in patients at risk.

Moderate

Lenvatinib (applies to Lenvima) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Hepatic failure, including fatal events have been reported with the use of lenvatinib. No dose adjustment is recommended in patients with mild or moderate hepatic impairment. Dose adjustment is needed in patients with severe hepatic impairment. It is recommended to monitor liver function before initiation of therapy with lenvatinib and regularly thereafter as clinically indicated. It might be necessary to temporarily withhold the use of lenvatinib and either resume at a reduced dose or discontinue treatment with lenvatinib depending on the severity and persistence of hepatic impairment. Discontinue treatment with lenvatinib for hepatic failure.

Moderate

Lenvatinib (applies to Lenvima) hypertension

Moderate Potential Hazard, Moderate plausibility.

The use of lenvatinib may cause hypertension. It is recommended to control blood pressure prior to treatment with lenvatinib and monitor blood pressure regularly during treatment as medically indicated. Withhold treatment with lenvatinib for Grade 3 hypertension despite optimal antihypertensive therapy. If clinically appropriate, resume at a reduced dose when hypertension is controlled and discontinue treatment for hypertension that becomes life-threatening. Care and close monitoring of blood pressure is recommended.

Moderate

Lenvatinib (applies to Lenvima) hypocalcemia

Moderate Potential Hazard, Moderate plausibility.

Cases of hypocalcemia have been reported with the use of lenvatinib. It is recommended to monitor blood calcium levels at least monthly and replace calcium as necessary during treatment and to interrupt and adjust dosing as necessary depending on severity, presence of ECG changes, and persistence of hypocalcemia. Care should be exercised when using this agent in patients at risk.

Moderate

Lenvatinib (applies to Lenvima) hypothyroidism

Moderate Potential Hazard, Moderate plausibility.

The use of lenvatinib impairs exogenous thyroid suppression and may cause hypothyroidism. It is recommended to monitor thyroid function before initiation of, and at least monthly throughout, treatment with lenvatinib. Care should be taken when using this agent in patients with thyroid dysfunction and treatment of hypothyroidism should be made according to standard medical practice to maintain a euthyroid state.

Moderate

Lenvatinib (applies to Lenvima) proteinuria

Moderate Potential Hazard, Moderate plausibility.

Proteinuria has been reported with the use of lenvatinib. It is recommended to monitor for proteinuria before initiation of, and periodically throughout treatment. Withhold lenvatinib for >=2 grams of proteinuria/24 hours and resume at a reduced dose when proteinuria is <2 gm/24 hours. Discontinue lenvatinib for nephrotic syndrome.

Moderate

Lenvatinib (applies to Lenvima) QT prolongation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias, Electrolyte Abnormalities

The use of lenvatinib may cause QT/QTc interval prolongation. It is recommended to monitor and correct electrolyte abnormalities in all patients and to monitor electrocardiograms in patients with congenital long QT syndrome, congestive heart failure, bradyarrhythmias, or those who are taking drugs known to prolong the QT interval, including Class Ia and III antiarrhythmics. Withhold treatment with lenvatinib for the development of QTc interval prolongation greater than 500 ms. and resume treatment at a reduced dose when QTc prolongation resolves to baseline.

Moderate

Lenvatinib (applies to Lenvima) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Cases of renal impairment have been reported with the use of lenvatinib. No dose adjustment is recommended in patients with mild or moderate renal impairment. Dose adjustment is needed in patients with severe renal impairment. It might be necessary to temporarily withhold the use of lenvatinib and either resume at a reduced dose or discontinue treatment with lenvatinib depending on the severity and persistence of renal impairment. Care and close monitoring is recommended when using lenvatinib in patients with end stage renal disease as these patients have not been studied.

Moderate

Lenvatinib (applies to Lenvima) RPL syndrome

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Posterior Reversible Encephalopathy Syndrome

The use of lenvatinib may cause reversible posterior leukoencephalopathy syndrome (RPLS). Consider this syndrome in any patient presenting with seizures, headache, visual disturbances, confusion or altered mental function. Confirm the diagnosis of RPLS with MRI and if positive, withhold therapy for RPLS until fully resolved. Upon resolution, resume at a reduced dose or discontinue treatment depending on the severity and persistence of neurologic symptoms and administer appropriate treatment as clinically indicated.

Moderate

Multikinase inhibitors (applies to Lenvima) lung toxicity

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Interstitial Pneumonitis, Pulmonary Impairment

The use of certain multikinase inhibitors has been associated with pulmonary toxicity. Serious cases of interstitial lung disease (ILD), including fatal cases and interstitial pneumonitis or pulmonary fibrosis have been reported. Caution is recommended when using these agents in patients with a history of interstitial pneumonitis or pulmonary fibrosis or those patients presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation. If ILD is confirmed, permanently discontinue these agents and institute appropriate measures. Immediately withhold treatment in patients diagnosed with ILD/pneumonitis and permanently discontinue therapy if no other potential causes of ILD/pneumonitis have been identified.

Lenvima (lenvatinib) drug interactions

There are 257 drug interactions with Lenvima (lenvatinib)

Lenvima (lenvatinib) alcohol/food interactions

There is 1 alcohol/food interaction with Lenvima (lenvatinib)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.