Onfi (clobazam) Disease Interactions
There are 3 disease interactions with Onfi (clobazam):
Benzodiazepines (Includes Onfi) ↔ Acute Alcohol Intoxication
Severe Potential Hazard, High plausibility
Applies to: Alcoholism, Acute Alcohol Intoxication
The use of benzodiazepines with alcohol is not recommended. Patients with acute alcohol intoxication exhibit depressed vital signs. The central nervous system depressant effects of benzodiazepines may be additive with those of alcohol, and severe respiratory depression and death may occur. Therapy with benzodiazepines should be administered cautiously in patients who might be prone to acute alcohol intake.
- "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Doral (quazepam)." Wallace Laboratories, Cranbury, NJ.
- "Product Information. Versed (midazolam)." Roche Laboratories, Nutley, NJ.
Benzodiazepines (Includes Onfi) ↔ Drug Dependence
Severe Potential Hazard, High plausibility
Applies to: Alcoholism, Drug Abuse/Dependence
Benzodiazepines have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use and/or excessive dosages. However, abrupt cessation following continual use of as few as 6 weeks at therapeutic levels has occasionally precipitated withdrawal symptoms. Addiction-prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance when treated with benzodiazepines. It may be prudent to refrain from dispensing large quantities of medication to these patients. After prolonged use or if dependency is suspected, withdrawal of benzodiazepine therapy should be undertaken gradually using a dosage-tapering schedule. If withdrawal symptoms occur, temporary reinstitution of benzodiazepines may be necessary.
- Specht U, Boenigk HE, Wolf P "Discontinuation of clonazepam after long-term treatment." Epilepsia 30 (1989): 458-63
- Rickels K, Schweizer E, Csanalosi I, Case WG, Chung H "Long-term treatment of anxiety and risk of withdrawal. Prospective comparison of clorazepate and buspirone." Arch Gen Psychiatry 45 (1988): 444-50
- Pecknold JC "Discontinuation reactions to alprazolam in panic disorder." J Psychiatr Res 27 (1993): 155-70
Benzodiazepines (Includes Onfi) ↔ Depression
Moderate Potential Hazard, Moderate plausibility
Applies to: Depression, Psychosis, Bipolar Disorder
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
- "Product Information. Halcion (triazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Klonopin (clonazepam)." Roche Laboratories, Nutley, NJ.
- "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Onfi (clobazam) drug Interactions
There are 951 drug interactions with Onfi (clobazam)
Onfi (clobazam) alcohol/food Interactions
There is 1 alcohol/food interaction with Onfi (clobazam)
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.