Skip to Content

Relaxazone (chlorzoxazone) Disease Interactions

There is 1 disease interaction with Relaxazone (chlorzoxazone):


Chlorzoxazone (Includes Relaxazone) ↔ Hepatotoxicity

Severe Potential Hazard, Low plausibility

Applies to: Liver Disease

The use of chlorzoxazone has been associated with rare cases of serious, idiosyncratic hepatocellular toxicity. Therapy with chlorzoxazone should be administered cautiously in patients with preexisting liver disease. All patients receiving chlorzoxazone should be instructed to immediately report any signs and symptoms of hepatic injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine and jaundice, and to discontinue the drug promptly should they occur. Chlorzoxazone therapy should also be withdrawn if abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase, bilirubin) develop.


  1. "Product Information. Parafon Forte (chlorzoxazone)." Ortho McNeol Pharmceutical, Raritan, NJ.

Relaxazone (chlorzoxazone) drug Interactions

There are 654 drug interactions with Relaxazone (chlorzoxazone)

Relaxazone (chlorzoxazone) alcohol/food Interactions

There is 1 alcohol/food interaction with Relaxazone (chlorzoxazone)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.