Marblen Disease Interactions
There are 6 disease interactions with Marblen (calcium carbonate / magnesium carbonate).
- Phosphate calcifications
- Cardiac contraction/conduction
- Malabsorption
- Renal dysfunction
- Sarcoidosis
- Renal dysfunction
Calcium salts (applies to Marblen) calcium- phosphate calcifications
Major Potential Hazard, High plausibility. Applicable conditions: Phosphate Imbalance
Elevated serum concentrations of calcium and phosphate can exceed the solubility level and result in calcium- phosphate precipitates that deposit in vascular and renal systems as well as other soft tissues of the body. Therapy with calcium should be administered with extreme caution in patients with hyperphosphatemia (hypoparathyroidism or severe renal impairment). Administration of oral calcium acetate or calcium carbonate, in addition to providing calcium, complexes phosphates within the GI tract. These complexes are eliminated in the feces. Clinical monitoring of serum calcium and phosphate concentrations is necessary.
Calcium salts (applies to Marblen) cardiac contraction/conduction
Major Potential Hazard, High plausibility. Applicable conditions: Arrhythmias
Calcium is involved in cardiac muscle contraction and electrical impulse conduction. Therapy with calcium salt formulations (particularly IV) should be administered cautiously to patients with cardiac disease. Patients receiving cardiac glycosides and concomitant IV calcium may experience arrhythmias. Therapy with IV calcium should be administered slowly and at reduced dosages in patients with cardiac disease.
Calcium salts (applies to Marblen) malabsorption
Major Potential Hazard, High plausibility. Applicable conditions: Achlorhydria, Malabsorption Syndrome
Calcium is absorbed from the intestinal tract by active transport and passive diffusion. Malabsorption syndromes (celiac disease, GI resection), deficiency of vitamin D, parathyroid hormone, or calcitonin, or an alkaline gastric pH (achlorhydria, carbonate or phosphate salts) can decrease the absorption of oral formulations of calcium. Calcium is available in oral and parenteral formulations.
Calcium salts (applies to Marblen) renal dysfunction
Major Potential Hazard, High plausibility.
Absorption of oral calcium formulations may be altered and elimination of calcium by the kidney decreased with renal impairment. Hyperphosphatemia occurs during renal failure. Calcium acetate or calcium carbonate, in addition to providing calcium, complexes phosphates within the GI tract. Calcium carbonate can partially correct metabolic acidosis associated with chronic renal failure. Clinical monitoring of renal function and serum calcium and phosphate concentrations is necessary.
Calcium salts (applies to Marblen) sarcoidosis
Major Potential Hazard, High plausibility.
Hypercalciuria, with or without hypercalcemia, may occasionally occur in patients with sarcoidosis. Elevated calcium levels may result from increased intestinal absorption of calcium, which is related to the extrarenal production of vitamin D by mononuclear phagocytes present within the sarcoid granuloma. Therapy with calcium salts should be administered cautiously and only if necessary in patients with sarcoidosis.
Magnesium salts (applies to Marblen) renal dysfunction
Major Potential Hazard, High plausibility.
Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.
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Marblen drug interactions
There are 269 drug interactions with Marblen (calcium carbonate / magnesium carbonate).
Marblen alcohol/food interactions
There is 1 alcohol/food interaction with Marblen (calcium carbonate / magnesium carbonate).
More about Marblen (calcium carbonate / magnesium carbonate)
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- Drug class: antacids
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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