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Siliq (brodalumab) Disease Interactions

There are 2 disease interactions with Siliq (brodalumab):


Brodalumab (Includes Siliq) ↔ Crohn's disease

Severe Potential Hazard, Moderate plausibility. Applies to: Inflammatory Bowel Disease

The use of brodalumab is contraindicated in patients with Crohn's disease as this agent may cause worsening of the disease. It is recommended to discontinue the use of brodalumab if patients develop Crohn's disease while on treatment.


Brodalumab (Includes Siliq) ↔ depression

Severe Potential Hazard, Moderate plausibility. Applies to: Depression

Suicidal ideation and behavior, including completed suicides, have occurred in patients treated with brodalumab. Patients with depression and other psychiatric disorders may experience worsening of their symptoms and may have the emergence of suicidal thoughts and behavior. Patients should be monitored appropriately and observed closely for worsening of their symptoms, suicidality or changes in their behavior. Prescribers should weigh the potential risks and benefits before using brodalumab in patients with a history of depression or suicidality. Families and caregivers should be advised of the need for close observation and communication with the treating physician.

Siliq (brodalumab) drug interactions

There are 110 drug interactions with Siliq (brodalumab)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.