Exna Disease Interactions
There are 2 disease interactions with Exna (benzthiazide).
Thiazides (applies to Exna) asthma
Moderate Potential Hazard, Moderate plausibility.
Thiazide diuretics should be used with caution in patients with history of bronchial asthma as sensitivity reactions may occur.
References (9)
- (2002) "Product Information. HydroDIURIL (hydrochlorothiazide)." Merck & Co., Inc
- (2002) "Product Information. Lozol (indapamide)." Rhone Poulenc Rorer
- (2001) "Product Information. Zaroxolyn (metolazone)." Rhone Poulenc Rorer
- (2001) "Product Information. Thalitone (chlorthalidone)." Monarch Pharmaceuticals Inc
- (2001) "Product Information. Diuril (chlorothiazide)." Merck & Co., Inc
- (2001) "Product Information. Enduron (methyclothiazide)." Abbott Pharmaceutical
- (2001) "Product Information. Metahydrin (trichlormethiazide)." Hoechst Marion Roussel
- (2001) "Product Information. Diucardin (hydroflumethiazide)." Wyeth-Ayerst Laboratories
- "Product Information. Renese-R (reserpine-polythiazide)." Pfizer US Pharmaceuticals, New York, NY.
Thiazides (applies to Exna) hyperuricemia
Moderate Potential Hazard, High plausibility. Applicable conditions: Gout
Thiazide diuretics decrease the rate of uric acid excretion. Hyperuricemia occurs frequently but is usually asymptomatic and rarely leads to clinical gout except in patients with a history of gout or chronic renal failure. Therapy with thiazide diuretics should be administered cautiously in such patients.
References (20)
- Lapidus PW, Guidotti FP (1963) "Gout in orthopaedic practice: review of 232 cases." Clin Orthop, 28, p. 97-110
- Labeeuw M, Pozet N, Aissa AH, Zech PY, Sassard J, Laville M (1988) "Uric acid renal handling: spontaneous changes and influence of a thiazide alone or associated with triamterene." Int J Clin Pharmacol Ther Toxicol, 26, p. 79-83
- Beling S, Vukovich RA, Neiss ES, Zisblatt M, Webb E, Losi M (1983) "Long-term experience with indapamide." Am Heart J, 106, p. 258-62
- Slotkoff L (1983) "Clinical efficacy and safety of indapamide in the treatment of edema." Am Heart J, 106, p. 233-7
- (2002) "Product Information. HydroDIURIL (hydrochlorothiazide)." Merck & Co., Inc
- (2002) "Product Information. Lozol (indapamide)." Rhone Poulenc Rorer
- (2001) "Product Information. Zaroxolyn (metolazone)." Rhone Poulenc Rorer
- (2001) "Product Information. Thalitone (chlorthalidone)." Monarch Pharmaceuticals Inc
- (2001) "Product Information. Diuril (chlorothiazide)." Merck & Co., Inc
- Brors O, Jacobsen S, Foss OP, Aakvaag A (1981) "Effect of repeated doses of hydroflumethiazide on renal excretion of electrolytes and uric acid in healthy subjects." Acta Pharmacol Toxicol (Copenh), 48, p. 145-50
- (2001) "Product Information. Enduron (methyclothiazide)." Abbott Pharmaceutical
- (2001) "Product Information. Metahydrin (trichlormethiazide)." Hoechst Marion Roussel
- (2001) "Product Information. Diucardin (hydroflumethiazide)." Wyeth-Ayerst Laboratories
- Gudbrandsson T, Hansson L (1979) "Combination therapy with saluretics and atenolol in essential hypertension. Effects on blood pressure, electrolytes and uric acid." Acta Med Scand Suppl, 625, p. 86-91
- Elmfeldt D, Berglund G, Wedel H, Wilhelmsen L (1983) "Incidence and importance of metabolic side-effects during antihypertensive therapy." Acta Med Scand Suppl, 672, p. 79-83
- Winchester JF, Kellett RJ, Boddy K, Boyle P, Dargie HJ, Mahaffey ME, Ward DM, Kennedy AC (1980) "Metolazone and bendroflumethiazide in hypertension: physiologic and metabolic observations." Clin Pharmacol Ther, 28, p. 611-8
- Petri M, Cumber P, Grimes L, Treby D, Bryant R, Rawlins D, Ising H (1986) "The metabolic effects of thiazide therapy in the elderly: a population study." Age Ageing, 15, p. 151-5
- Ljunghall S, Backman U, Danielson BG, Fellstrom B, Johansson G, Odlind B, Wikstrom B (1982) "Effects of bendroflumethiazide on urate metabolism during treatment of patients with renal stones." J Urol, 127, p. 1207-10
- "Product Information. Renese-R (reserpine-polythiazide)." Pfizer US Pharmaceuticals, New York, NY.
- Freis ED (1995) "The efficacy and safety of diuretics in treating hypertension." Ann Intern Med, 122, p. 223-6
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Exna drug interactions
There are 463 drug interactions with Exna (benzthiazide).
Exna alcohol/food interactions
There is 1 alcohol/food interaction with Exna (benzthiazide).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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