Lotronex (alosetron) Disease Interactions
There are 4 disease interactions with Lotronex (alosetron):
Alosetron (Includes Lotronex) ↔ Gastrointestinal Complications
Severe Potential Hazard, Moderate plausibility
Applies to: Gastrointestinal Obstruction, Gastrointestinal Perforation, Constipation
Alosetron is contraindicated in patients with a history of severe bowel complications. Patients with serious complications of constipation, including history of chronic or severe constipation or sequelae from constipation; intestinal obstruction, stricture, toxic megacolon, gastrointestinal perforation, and/or adhesions; ischemic colitis; obstruction, ileus, impaction, toxic megacolon, secondary bowel ischemia, and impaired intestinal circulation should not use alosetron. Care should be exercised when using this agent in patients at risk.
Alosetron (Includes Lotronex) ↔ Hepatic Impairment
Severe Potential Hazard, Moderate plausibility
Applies to: Liver Disease
Alosetron is extensively metabolized by the liver. The use of alosetron is contraindicated in patients with severe hepatic impairment and it should be used with caution in patients with mild or moderate hepatic impairment. Close monitoring is recommended.
Alosetron (Includes Lotronex) ↔ Thrombotic Disorders
Severe Potential Hazard, Moderate plausibility
Applies to: Thrombotic/Thromboembolic Disorder
The use of alosetron is contraindicated in patients with coagulation abnormalities such as thrombophlebitis, or hypercoagulable state.
Alosetron (Includes Lotronex) ↔ Renal Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Renal Dysfunction
Renal impairment has no effect on the renal elimination of alosetron due to the minor contribution of this pathway to elimination. Care should be exercised as the effect of renal impairment on metabolite pharmacokinetics and the effect of end-stage renal disease have not been assessed.
Lotronex (alosetron) drug Interactions
There are 93 drug interactions with Lotronex (alosetron)
Lotronex (alosetron) alcohol/food Interactions
There is 1 alcohol/food interaction with Lotronex (alosetron)
See Also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
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