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Abaloparatide Disease Interactions

There are 3 disease interactions with abaloparatide.

Major

Parathyroid hormone/analogs (applies to abaloparatide) hyperparathyroidism

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hypercalcemia

Patients known to have an underlying hypercalcemic disorder, such as primary hyperparathyroidism, should not be treated with parathyroid hormone and its analogs because of the risk of exacerbating hypercalcemia.

References

  1. "Product Information. Forteo (teriparatide)." Lilly, Eli and Company (2002):
  2. "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals (2015):
  3. "Product Information. Tymlos (abaloparatide)." Radius Health (2017):
Major

Parathyroid hormone/analogs (applies to abaloparatide) malignancy

Major Potential Hazard, Moderate plausibility. Applicable conditions: Neoplasm of Bone, Paget's Disease

Parathyroid hormone and its analogs should not be used in patients who are at increased baseline risk for osteosarcoma. These agents should only be used if the potential benefits are considered to outweigh the potential risks. Monitor these patients according to clinical guidelines. Patients with bone metastases or a history of skeletal malignancies should not be treated with these agents.

References

  1. "Product Information. Forteo (teriparatide)." Lilly, Eli and Company (2002):
  2. "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals (2015):
  3. "Product Information. Tymlos (abaloparatide)." Radius Health (2017):
Moderate

Abaloparatide (applies to abaloparatide) urolithiasis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Nephrolithiasis

No dosage adjustment is required for patients with mild, moderate, or severe renal impairment. Patients with severe renal impairment may have increased abaloparatide exposure that may increase the risk of adverse reactions; therefore, monitor for adverse reactions. Abaloparatide may exacerbate urolithiasis in patients with active or a history of urolithiasis. If active urolithiasis or preexisting hypercalciuria is suspected, measurement of urinary calcium excretion should be considered.

References

  1. "Product Information. Tymlos (abaloparatide)." Radius Health (2017):

Abaloparatide drug interactions

There are 4 drug interactions with abaloparatide.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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