Generic Name: mepolizumab (Subcutaneous route)
Medically reviewed by Drugs.com. Last updated on Sep 1, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antiasthma
Pharmacologic Class: Monoclonal Antibody
Uses for Nucala
Mepolizumab injection is used with other medicines to treat severe asthma. It is given to patients whose asthma is not controlled with their current asthma medicines. It is also used to treat eosinophilic granulomatosis with polyangiitis (EGPA) in adults.
This medicine is to be given only by or under the direct supervision of your doctor.
Before using Nucala
Appropriate studies have not been performed on the relationship of age to the effects of mepolizumab injection to treat severe asthma in children younger than 6 years of age. Safety and efficacy have not been established.
Appropriate studies have not been performed on the relationship of age to the effects of mepolizumab injection to treat EGPA in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mepolizumab injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving mepolizumab injection.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Other medical problems
- Parasitic infections—Should be treated first before receiving this medicine.
Proper use of Nucala
A nurse or other trained health professional will give you or your child this medicine. It is given as a shot under your skin, usually on the upper arms, abdomen or stomach, or thigh once every 4 weeks.
Mepolizumab injection may sometimes be given at home to patients who do not need to be in the hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to inject the medicine. Be sure that you understand exactly how to use this.
This medicine comes with a patient information leaflet. Read and follow the instructions carefully . Ask your doctor if you have questions.
If you use this medicine at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems. Do not inject into scars, moles, or skin areas that are red, bruised, tender, hard, or not intact.
This medicine is available in 2 forms. You may use a prefilled syringe or a prefilled autoinjector.
Allow the prefilled syringe or prefilled autoinjector to warm to room temperature 30 minutes before using it. Do not warm it in any other way.
Check the liquid in the prefilled syringe or prefilled autoinjector. It should be clear and colorless or slightly yellow. Do not use this medicine if it is cloudy or if there are particles in it. Do not use the prefilled syringe or autoinjector if it looks damaged or broken.
Use all of the medicine in each prefilled syringe or autoinjector. Use each prefilled syringe and autoinjector only one time. Do not save an open syringe or autoinjector.
This medicine must be injected within 8 hours after removal from the carton. Throw away if not used within 8 hours.
- For injection dosage forms (prefilled syringe or prefilled autoinjector):
- For severe asthma:
- Adults and children 12 years of age and older—100 milligrams (mg) injected under your skin once every 4 weeks.
- Children 6 to 11 years of age—40 mg injected under your skin once every 4 weeks.
- Children younger than 6 years of age—Use and dose must be determined by your doctor.
- For EGPA:
- Adults—300 milligrams (mg) injected under your skin once every 4 weeks (given as 3 separate 100 mg injections injected 5 cm apart if given at the same injection site).
- Children—Use and dose must be determined by your doctor.
- For severe asthma:
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Store in the refrigerator. Do not freeze.
Protect this medicine from direct light. Keep it in its original package until you are ready to use it. Do not shake. You may also keep an unopened carton at room temperature for up to 7 days. Throw away any medicine left out of the refrigerator for more than 7 days.
Throw away used syringes in a hard, closed container where the needles cannot poke through. Keep this container away from children and pets.
Precautions while using Nucala
It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.
Serious allergic reactions may occur after receiving this medicine. Tell your doctor right away if you or your child have the following symptoms: cough, rash, itching skin, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs, trouble breathing, lightheadedness, dizziness, or fainting.
This medicine will not stop an asthma attack that has already started. Your doctor may prescribe another medicine for you to use in case of an asthma attack.
This medicine may lead to herpes zoster infection (shingles). You may receive a vaccine before you start treatment. Tell your doctor if you have not had either chickenpox or the chickenpox vaccine.
If you use a corticosteroid medicine (inhaled or taken by mouth) to control your asthma, keep using it unless your doctor tells you otherwise.
Nucala side effects
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
- Blurred vision
- difficulty with breathing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- hives or welts, itching, or skin rash
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- noisy breathing
- painful blisters on the trunk of the body
- redness of the skin
- tightness in the chest
- unusual tiredness or weakness
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- Back pain
- bladder pain
- bloody or cloudy urine
- difficult, burning, or painful urination
- frequent urge to urinate
- general feeling of discomfort or illness
- joint pain
- loss of appetite
- lower back or side pain
- muscle aches, pains, or spasms
- runny nose
- skin rash, encrusted, scaly, and oozing
- sore throat
- trouble sleeping
- upper abdominal or stomach pain
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More about Nucala (mepolizumab)
- Side Effects
- During Pregnancy
- Dosage Information
- Support Group
- Pricing & Coupons
- En Español
- 39 Reviews
- Drug class: interleukin inhibitors
- FDA Approval History