lacosamide (Intravenous route)Pronunciation
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Anticonvulsant
Uses For lacosamide
Lacosamide injection is used to control partial seizures (convulsions) in the treatment of epilepsy. It acts on the central nervous system (CNS) to reduce the number and severity of seizures.
lacosamide is available only with your doctor's prescription.
Before Using lacosamide
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lacosamide, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to lacosamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of lacosamide injection in children younger than 17 years of age. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lacosamide injection in the elderly. However, elderly patients are more likely to have age-related heart, kidney, or liver problems, which may require caution in patients receiving lacosamide injection.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving lacosamide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using lacosamide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Eslicarbazepine Acetate
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of lacosamide. Make sure you tell your doctor if you have any other medical problems, especially:
- Brugada syndrome (genetic disease) or
- Depression, history of or
- Drug abuse or dependence, history of or
- Heart attack or
- Heart block or
- Heart disease (eg, heart failure, myocardial ischemia) or
- Heart failure or
- Heart rhythm problems (eg, prolonged PR interval) or
- Mental illness, history of or
- Sick sinus syndrome (type of abnormal heart rhythm), without pacemaker—Use with caution. May make these conditions worse.
- Diabetic neuropathy or
- Heart or blood vessel disease—May increase risk for more serious side effects.
- Kidney disease, severe or
- Liver disease, mild to moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Liver disease, severe—Should not be used in patients with this condition.
Proper Use of lacosamide
A nurse or other trained health professional will give you lacosamide in a hospital. lacosamide is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 15 to 60 minutes.
Your doctor may give you a few doses of lacosamide until your condition improves, and then you may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.
lacosamide should come with a Medication Guide. It is very important that you read and understand this information. Ask your doctor if you have any questions.
Precautions While Using lacosamide
It is very important that your doctor check your progress at regular visits to make sure lacosamide is working properly. Blood tests may be needed to check for unwanted effects.
It is important to tell your doctor if you become pregnant or planning to become pregnant. Your doctor may want you to join the North American Antiepileptic Drug Pregnancy Registry. This registry is used by pregnant patients who are using lacosamide.
If you develop any unusual or strange thoughts and behavior while receiving lacosamide injection, be sure to discuss it with your doctor. Some changes that have occurred in people receiving lacosamide are like those seen in people who drink too much alcohol. Other changes might be confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.
lacosamide may cause blurred vision, double vision, clumsiness, unsteadiness, dizziness, drowsiness, sleepiness, or trouble with thinking. Make sure you know how you react to lacosamide before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well. If these side effects are especially bothersome, check with your doctor.
lacosamide can cause changes in heart rhythms, such as a condition called PR prolongation. It may change the way your heart beats and cause lightheadedness, fainting, or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, slow, or irregular heartbeats.
Lacosamide injection may cause serious allergic reactions affecting multiple body organs (eg, liver or kidney). Check with your doctor right away if you have the following symptoms: fever, dark urine, headache, rash, stomach pain, swollen, painful, or tender lymph glands in the neck, armpit, or groin, unusual tiredness, or yellow eyes or skin.
lacosamide Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- shakiness and unsteady walk
- sleepiness or unusual drowsiness
- trembling or shaking of the hands or feet
- unsteadiness, trembling, or other problems with muscle control or coordination
- Being forgetful
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- feeling sad or empty
- itching skin
- lack of appetite
- loss of balance control
- loss of interest or pleasure
- mood or mental changes
- tearing of the skin
- trouble concentrating
- trouble with sleeping
- trouble with walking
- Chest pain or discomfort
- flushing or redness of the skin
- lightheadedness, dizziness, or fainting
- shortness of breath
- slow or irregular heartbeat
- unusual tiredness
- unusually warm skin
- Abnormal or decreased touch sensation
- black, tarry stools
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- changes in patterns and rhythms of speech
- continuing ringing or buzzing or other unexplained noise in the ears
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling drunk
- hearing loss
- lower back or side pain
- painful or difficult urination
- pale skin
- slurred speech
- sore throat
- trouble performing routine tasks
- trouble with balance
- trouble with speaking
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Blurred vision
- double vision
- seeing double
- feeling of constant movement of self or surroundings
- lack or loss of strength
- sensation of spinning
- uncontrolled eye movements
- Acid or sour stomach
- difficulty having a bowel movement (stool)
- dry mouth
- muscle spasms
- stomach discomfort, upset, or pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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