Ceftolozane and tazobactam (Intravenous)
Generic Name: ceftolozane/tazobactam (sef-TOL-oh-zane, taz-oh-BAK-tam)
Medically reviewed by Drugs.com. Last updated on Sep 24, 2020.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antibiotic Combination
Pharmacologic Class: Cephalosporin
Uses for ceftolozane and tazobactam
Ceftolozane and tazobactam combination injection is used alone or in combination with metronidazole to treat complicated bacterial infections in many different parts of the body (eg, stomach, kidneys). It is also used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).
Ceftolozane and tazobactam combination is an antibiotic that belongs to the group of medicines known as cephalosporins and beta-lactamase inhibitors. It works by killing bacteria and preventing their growth. However, ceftolozane and tazobactam will not work for colds, flu, or other virus infections.
Ceftolozane and tazobactam is to be given only by or under the direct supervision of your doctor.
Before using ceftolozane and tazobactam
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ceftolozane and tazobactam, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to ceftolozane and tazobactam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of ceftolozane and tazobactam combination injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ceftolozane and tazobactam combination injection in the elderly. However, elderly patients are more likely to have unwanted effects and age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving ceftolozane and tazobactam combination injection.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving ceftolozane and tazobactam, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ceftolozane and tazobactam with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Cholera Vaccine, Live
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of ceftolozane and tazobactam. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to cephalosporins, beta-lactams, or penicillins, history of or
- Diarrhea—Use with caution. May make these conditions worse.
- End-stage kidney disease or
- Kidney disease, moderate to severe—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.
Proper use of ceftolozane and tazobactam
A nurse or other trained health professional will give you ceftolozane and tazobactam in a medical facility. It is given through a needle placed into one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for at least 1 hour.
Precautions while using ceftolozane and tazobactam
It is very important that your doctor check your progress closely while you are receiving ceftolozane and tazobactam. This is to make sure that the medicine is working properly and that the infection is cleared up completely. Blood and urine tests may be needed to check for unwanted effects.
Ceftolozane and tazobactam may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive ceftolozane and tazobactam.
Ceftolozane and tazobactam combination may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop receiving ceftolozane and tazobactam. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.
Ceftolozane and tazobactam side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Bloody urine
- blurred vision
- decreased frequency or amount of urine
- increased thirst
- loss of appetite
- lower back or side pain
- pounding in the ears
- slow or fast heartbeat
- swelling of the face, fingers, or lower legs
- trouble breathing
- unusual tiredness or weakness
- weight gain
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- headache, sudden and severe
- irregular heartbeat
- mood changes
- muscle pain or cramps
- numbness or tingling in the hands, feet, or lips
- pale skin
- skin rash
- stomach cramps
- tenderness in the stomach area
- troubled breathing with exertion
- unusual bleeding or bruising
- watery or bloody diarrhea
- bone pain
- burning feeling in the chest or stomach
- chest pain
- dry mouth
- dry, red, hot, or irritated skin
- fast, pounding, or irregular heartbeat or pulse
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased urination
- muscle spasms (tetany) or twitching
- severe constipation
- severe vomiting
- stomach pain or upset
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
- thick, white, or curd-like vaginal discharge
- tightness in the chest
- trouble thinking, speaking, or walking
- unexplained weight loss
- white patches in the mouth or throat or on the tongue
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- trouble sleeping
- bloated or full feeling
- excess air or gas in the stomach or bowels
- passing gas
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about ceftolozane / tazobactam
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: cephalosporins/beta-lactamase inhibitors
- Other brands
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.