Comparing Sitagliptin vs Tradjenta

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Sitagliptin	Tradjenta (linagliptin)	Enter another drug to compare

Sitagliptin

Tradjenta (linagliptin)

Prescription only

Prescribed for Type 2 Diabetes. Sitagliptin may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Type 2 Diabetes. Tradjenta may also be used for purposes not listed in this medication guide.

More about Sitagliptin

More about Tradjenta (linagliptin)

Ratings & Reviews

Sitagliptin has an average rating of 4.4 out of 10 from a total of 154 ratings on Drugs.com. 27% of reviewers reported a positive effect, while 53% reported a negative effect.

Tradjenta has an average rating of 3.5 out of 10 from a total of 74 ratings on Drugs.com. 22% of reviewers reported a positive effect, while 69% reported a negative effect.

View all 154 reviews

View all 74 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Diarrhea (11.7%)
Joint pain (9.1%)
Nausea (7.1%)
Upset stomach (5.8%)
Shortness of breath (5.2%)
Swelling (5.2%)
Vomiting (5.2%)

View all Sitagliptin side effects

Joint pain (14.9%)
Back pain (13.5%)
Dizziness (10.8%)
Headaches (9.5%)
Stomach pain (9.5%)
Tiredness (8.1%)
Weight gain (8.1%)

View all Tradjenta side effects

Drug Class

Dipeptidyl peptidase 4 inhibitors

Dipeptidyl peptidase 4 inhibitors

Generic Availability

Lower cost generic

Lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	30 tablet
Strength	(as base) 25 mg
Per unit^*	$8.28
Cost^*	$248.42

View all Sitagliptin prices

Quantity	100 each
Strength	5 mg
Per unit^*	$18.78
Cost^*	$1,878.45

View all Tradjenta prices

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Dosage Forms

Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

12.4 hours

12 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 296 drugs are known to interact with Sitagliptin:

2 major drug interactions (5 brand and generic names)
289 moderate drug interactions (1522 brand and generic names)
5 minor drug interactions (24 brand and generic names)

A total of 349 drugs are known to interact with Tradjenta:

2 major drug interactions (5 brand and generic names)
346 moderate drug interactions (1655 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Disease Interactions

Pancreatitis

First Approval Date

October 16, 2006

May 02, 2011

WADA Class View classifications

N/A

More Information

Patient Resources

Sitagliptin uses

Tradjenta uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Sitagliptin vs Tradjenta

See also:

Trulicity

Lantus

Ozempic

Tresiba

Victoza

Levemir

Basaglar

Novolog

Toujeo SoloStar

Soliqua

Further information

Comparing Sitagliptin vs Tradjenta

See also:

Further information

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