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Progesterone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Progesterone Remove Progesterone from your drug comparison Prometrium Remove Prometrium from your drug comparison Endometrin Remove Endometrin from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Progesterone Remove Progesterone from your drug comparison Prometrium progesterone Remove Prometrium from your drug comparison Endometrin progesterone Remove Endometrin from your drug comparison

Progesterone is a female hormone that is used to treat disorders associated with ovulation, fertility, menstruation, and menopause. It may increase the risk of blood clots. Prescribed for Female... View more

Prescribed for Amenorrhea, Endometrial Hyperplasia - Prophylaxis, Progesterone Insufficiency, Uterine Bleeding, Perimenopausal Symptoms, Premature Labor. Prometrium may also be used for purposes not... View more

Prescribed for Amenorrhea, Endometrial Hyperplasia - Prophylaxis, Progesterone Insufficiency, Uterine Bleeding, Perimenopausal Symptoms, Premature Labor. Endometrin may also be used for purposes not... View more

Prescription and OTC

Prescription and OTC

Prescription and OTC

Ratings & Reviews

View all 64 reviews

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Drug Class

Side Effects

Commonly reported side effects include: abdominal cramps, depression, dizziness, headache.

See the full progesterone side effects document.

Common side effects include: abdominal cramps, dizziness, headache.

See the full Prometrium side effects document.

See the full Endometrin side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 100 capsule
Dosage 100 mg
Per Unit* $1.08 - $1.28
Cost* $107.50 - $127.77

View all progesterone prices

Quantity 10 capsule
Dosage 200 mg
Per Unit* $5.42
Cost* $54.15

View all Prometrium prices and generic prices

Quantity 21 insert
Dosage 100 mg
Per Unit* $14.14
Cost* $296.87

View all Endometrin prices and generic prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes

Yes

Dosage Form(s) Available
  • Intramuscular solution
  • Oral capsule
  • Oral capsule
  • Vaginal insert

Brand Names
Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa, Prometrium Other progesterone brands include: Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa Other progesterone brands include: Crinone, Cyclogest, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa, Prometrium

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

1 hour

1 hour

1 hour

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
B
Category B No proven risk in humans

Oral Formulations

N
Category N Not classified

Excluding Oral Formulations

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

Oral Formulations

N
Category N Not classified

Excluding Oral Formulations

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

Oral Formulations

N
Category N Not classified

Excluding Oral Formulations

See the full Pregnancy Warnings document.

FDA Alerts

N/A

N/A

N/A

Drug Interactions

A total of 165 drugs are known to interact with progesterone:

  • 2 major drug interactions (4 brand and generic names)
  • 156 moderate drug interactions (476 brand and generic names)
  • 7 minor drug interactions (14 brand and generic names)

A total of 165 drugs are known to interact with Prometrium:

  • 2 major drug interactions (4 brand and generic names)
  • 156 moderate drug interactions (476 brand and generic names)
  • 7 minor drug interactions (14 brand and generic names)

A total of 165 drugs are known to interact with Endometrin:

  • 2 major drug interactions (4 brand and generic names)
  • 156 moderate drug interactions (476 brand and generic names)
  • 7 minor drug interactions (14 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Grapefruit juice may increase the blood levels of certain medications such as progesterone. You... View more
  • Grapefruit juice may increase the blood levels of certain medications such as progesterone. You... View more
  • Grapefruit juice may increase the blood levels of certain medications such as progesterone. You... View more

Disease Interactions

First Approval Date

November 01, 1974

May 14, 1998

June 21, 2007

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

N/A

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer