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Phospholine Iodide Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Phospholine Iodide (echothiophate iodide) Combigan (brimonidine / timolol) Acetazolamide
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Phospholine Iodide (echothiophate iodide) Combigan (brimonidine / timolol) Acetazolamide
Prescription only

Prescribed for Glaucoma. Phospholine Iodide may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Glaucoma/Intraocular Hypertension, Glaucoma, Intraocular Hypertension. Combigan may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Hydrocephalus, Glaucoma, Edema, Epilepsy, Hypokalemic Periodic Paralysis, Mountain Sickness / Altitude Sickness, Pseudotumor Cerebri, Seizure Prevention, Seizures. Acetazolamide may... View more

More about Phospholine Iodide (echothiophate iodide) More about Combigan (brimonidine / timolol) More about Acetazolamide
Ratings & Reviews

Phospholine Iodide has an average rating of 10.0 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect.

Combigan has an average rating of 4.9 out of 10 from a total of 25 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 48% reported a negative effect.

Acetazolamide has an average rating of 6.4 out of 10 from a total of 192 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 26% reported a negative effect.

View all 2 reviews

View all 25 reviews

View all 192 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Phospholine Iodide side effects

View all Combigan side effects

View all Acetazolamide side effects
Drug Class
Generic Availability

No lower cost generic approved

Lower cost generic approved

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 5 mL
Strength 0.125%
Per unit* $612.87
Cost* $3,064.37

View all Phospholine Iodide prices

Quantity 5 mL
Strength 0.2%-0.5%
Per unit* $45.58
Cost* $227.92

View all Combigan prices

Quantity 50 each
Strength 250 mg
Per unit* $2.51
Cost* $125.33

View all Acetazolamide prices

Get free Discount Card

Get free Discount Card

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Dosage Forms
  • Ophthalmic powder for reconstitution
  • Ophthalmic solution
  • Intravenous powder for injection
  • Oral capsule, extended release
  • Oral tablet
Brand Names

N/A

N/A

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

N/A

7 hours

4 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 110 drugs are known to interact with Phospholine Iodide:

  • 1 major drug interactions (2 brand and generic names)
  • 109 moderate drug interactions (607 brand and generic names)

A total of 548 drugs are known to interact with Combigan:

  • 29 major drug interactions (169 brand and generic names)
  • 515 moderate drug interactions (2015 brand and generic names)
  • 4 minor drug interactions (12 brand and generic names)

A total of 263 drugs are known to interact with Acetazolamide:

  • 23 major drug interactions (164 brand and generic names)
  • 222 moderate drug interactions (992 brand and generic names)
  • 18 minor drug interactions (56 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • After using brimonidine ophthalmic, some of the medication may be absorbed into the bloodstream and... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
First Approval Date

June 27, 1960

October 30, 2007

July 27, 1953
WADA Class View classifications

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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