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Mitomycin ophthalmic

Generic name: mitomycin ophthalmic [ MYE-toe-MYE-sin-off-THAL-mik ]
Brand name: Mitosol
Dosage form: ophthalmic kit (0.2 mg)
Drug class: Miscellaneous ophthalmic agents

Medically reviewed by on Oct 11, 2023. Written by Cerner Multum.

What is mitomycin ophthalmic?

Mitomycin is an antimetabolite medicine that interferes with the growth and spread of certain cells in the body.

Mitomycin ophthalmic (for the eyes) is used during glaucoma surgery.

Mitomycin ophthalmic may also be used for purposes not listed in this medication guide.

Mitomycin ophthalmic side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mitomycin ophthalmic may cause serious side effects. Call your doctor at once if you have:

Common side effects of mitomycin ophthalmic may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not be treated with mitomycin ophthalmic if you are pregnant.

Before taking this medicine

You should not be treated with this medicine if you are allergic to mitomycin.

You should not be treated with mitomycin ophthalmic if you are pregnant, or if you think you may be pregnant. Mitomycin could harm the unborn baby or cause birth defects.

Before you receive mitomycin ophthalmic, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding.

It is not known whether mitomycin ophthalmic passes into breast milk or if it could harm a nursing baby. You should not breast-feed after being treated with this medicine. Follow your doctor's instructions about how long after treatment you should wait before you can breast-feed again.

How is mitomycin ophthalmic used?

A healthcare provider will apply mitomycin ophthalmic to your eye(s) during glaucoma surgery.

Glaucoma surgery is usually performed while you are awake. You will be given medicine to numb your eyes and reduce pain or discomfort during your surgery.

If general anesthesia is used for your surgery, you will not be awake during the operation.

Mitomycin ophthalmic is a liquid medicine that is applied first to a tray of tiny sponges. The sponges will soak in the mitomycin for at least 60 minutes.

Once the sponges are saturated with mitomycin, your surgeon will place the sponges directly onto your eye.

The sponges will be left in place for 2 minutes and then removed.

After the sponges are removed, your eye will be rinsed thoroughly.

Your doctor may prescribe other eye medications for you to use after surgery. Use all medications as directed. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Mitomycin ophthalmic dosing information

Usual Adult Dose for Glaucoma:

-Usual dose: 0.2 mg applied with saturated sponges (provided in the kit) equally to the treatment area with surgical forceps
-Duration of therapy: 2 minutes

-This drug should not be administered intraocularly.
-After 2 minutes, sponges and preparation materials should be discarded in a chemotherapy waste bag.

Use: As an adjunct to ab externo glaucoma surgery

What happens if I miss a dose?

Because you will receive mitomycin ophthalmic in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since mitomycin ophthalmic is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving mitomycin ophthalmic?

Do not use other eye medications unless your doctor tells you to.

What other drugs will affect mitomycin ophthalmic?

It is not likely that other drugs you take orally or inject will have an effect on mitomycin used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

More about mitomycin ophthalmic

Patient resources

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Professional resources

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.