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Kymriah Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Kymriah Blincyto Methotrexate
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Kymriah (tisagenlecleucel) Blincyto (blinatumomab) Methotrexate
Prescription only

Prescribed for Acute Lymphoblastic Leukemia, B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma, Follicular Lymphoma. Kymriah may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Acute Lymphoblastic Leukemia. Blincyto may also be used for purposes not listed in this medication guide.

Prescription only

Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more

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More about Kymriah (tisagenlecleucel) More about Blincyto (blinatumomab) More about Methotrexate
Generic Status

No lower-cost generic available

No lower-cost generic available

Lower-cost generic is available
Ratings & Reviews

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Methotrexate has an average rating of 6.5 out of 10 from a total of 327 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 23% reported a negative effect.

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Review this drug

View all 327 reviews

Drug Class
Side Effects

See also: Kymriah side effects in more detail.

Common side effects include:

  • encephalopathy
  • seizure disorder
  • febrile neutropenia
  • opportunistic infection
  • balance impairment
  • confusion
  • cytokine release syndrome
  • disorientation
  • headache
  • impaired consciousness
  • tremor
  • fever
  • hypotension
  • increased serum alanine aminotransferase
  • increased serum aspartate aminotransferase
  • nausea
  • neutropenia
  • speech disturbance
  • bacteremia
  • show all 19

See also: Blincyto side effects in more detail.

Commonly reported side effects include:

  • increased liver enzymes

See also: methotrexate side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 1 suspension
Dosage -
Per Unit* $572,659.86
Cost* $572,659.86

View all Kymriah prices

Quantity 1 powder for injection
Dosage 35 mcg
Per Unit* $5,169.36
Cost* $5,169.36

View all Blincyto prices

Quantity 20 each
Dosage 2.5 mg
Per Unit* $1.77
Cost* $35.42

View all methotrexate prices

Get free Discount Card

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Dosage Form(s) Available
  • Intravenous suspension
  • Intravenous powder for injection
  • Injectable powder for injection
  • Injectable solution
  • Oral tablet
Brand Names

N/A

N/A

 Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

403.2 hours

2.11 hours

15 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category

Summary unavailable.

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.
Drug Interactions

A total of 153 drugs are known to interact with Kymriah:

  • 43 major drug interactions (119 brand and generic names)
  • 110 moderate drug interactions (325 brand and generic names)

A total of 219 drugs are known to interact with Blincyto:

  • 53 major drug interactions (183 brand and generic names)
  • 165 moderate drug interactions (569 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 668 drugs are known to interact with methotrexate:

  • 133 major drug interactions (626 brand and generic names)
  • 519 moderate drug interactions (2606 brand and generic names)
  • 16 minor drug interactions (51 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
  • Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more
Disease Interactions
First Approval Date

N/A

December 03, 2014

December 07, 1953
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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