Comparing Imbruvica vs Methotrexate
| Imbruvica Remove Imbruvica from your drug comparison | Methotrexate Remove Methotrexate from your drug comparison |
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| Imbruvica ibrutinib Remove Imbruvica from your drug comparison | Methotrexate Remove Methotrexate from your drug comparison | ||||||||||||||||
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Imbruvica is an oral tablet that may be taken once daily to treat certain types of cancers. It works by inhibiting the enzyme Bruton tyrosine kinase (BTK) which is part of a crucial signaling... View more |
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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5.8
For Chronic Lymphocytic Leukemia: Due to my having a variant GI system (with its own side-effects), my oncologist, in an abundance of caution, started me on Imbruvica 1 capsule in the AM, daily. Literally within days, the SIGNIFICANTLY large lymphs in the front and rear of my neck, disappeared. WOW! MY WBC's skyrocketed, but that is typically expected due to the mechanisms by which Imbruvica works. Oversimplifying here -- the abnormal (cancerous) cells, congregate in the lymphs. Imbruvica forces those abnormal cells out into the bloodstream, where they can be attacked and starved of the BTK protein, which they need to thrive and propagate. The "dead" abnormal cells are then flushed out of the body. After 2 months dose upped to 2 capsules daily, and still tolerating well. |
6.7
For Rheumatoid Arthritis: I had taken MTX in past but it did not work out for me due to rash proplem caused by MTX so Doctor recommended Sulfasalazine and it worked out very good for about 4 years but the end of friendship came to us...Sulfasalazine was not effective anymore. I met a Doctor who practice natrual madicine also ER Dortor at the local hospital....He recommended 3 natrual Supplements for RA and pain( Turmeric, Wobenzym N, White Willow) and they are very effective (on me) and it is better than Chemical based medications. I have been off from those deadly medications for 5 months now. For Rheumatoid Arthritis: I have been on 15mg then 20mg for two years. Then developed constant explosive diarrhea, dizziness, and confusion. Judged to be allergic, and told to stop the medication immediately. The symptoms continue...how long before it gets better? I am not taking anything for RA right now after a week off methotrexate. |
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Drug Class |
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Side Effects |
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Common side effects include: infection, anemia, neutropenia, thrombocytopenia, bruise, and cytopenia. See the full Imbruvica side effects document. |
Commonly reported side effects include: increased liver enzymes. See the full methotrexate side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all Imbruvica prices |
View all methotrexate prices |
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Generic Availability |
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No |
Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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N/A |
Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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6 hours |
12 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category D
Positive evidence of risk
See the full Pregnancy Warnings document. |
Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
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FDA Alerts |
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N/A |
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Drug Interactions |
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A total of 368 drugs are known to interact with Imbruvica:
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A total of 589 drugs are known to interact with methotrexate:
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Alcohol/Food/Lifestyle Interactions |
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Disease Interactions |
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First Approval Date |
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November 13, 2013 |
December 07, 1953 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Chronic Lymphocytic Leukemia: I've been on Imbruvica for only 6 weeks because of bad side effects my doctor stopped the medication. Since I started taking the medication in October 2019 and now is October 2020 still have the diarrhea. I tried all medications and some teas to stopped it. Really don't know what to do.