Comparing Fosphenytoin vs Phenytoin

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Fosphenytoin

Phenytoin

Prescription only

Prescribed for Epilepsy, Status Epilepticus. Fosphenytoin may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Epilepsy, Seizures, Anxiety, Arrhythmia, Cluster-Tic Syndrome, Neurosurgery, Status Epilepticus, Seizure Prophylaxis During or Following Neurosurgery, Myotonia Congenita, Peripheral... View more

More about Fosphenytoin

More about Phenytoin

Ratings & Reviews

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Phenytoin has an average rating of 7.5 out of 10 from a total of 117 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 15% reported a negative effect.

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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Fosphenytoin side effects

Dizziness (10.3%)
Rash (7.7%)
Memory loss (6.8%)
Swelling (6.8%)
Seizures (5.1%)
Fever (4.3%)
Drowsiness (3.4%)

View all Phenytoin side effects

Drug Class

Hydantoin anticonvulsants

Hydantoin anticonvulsants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 mL
Strength	100 mgPE/2 mL
Per unit^*	$2.21 - $6.50
Cost^*	$110.59 - $325.00

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Quantity	200 mL
Strength	25 mg/mL
Per unit^*	$1.46
Cost^*	$291.40

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Dosage Forms

Injectable solution

Oral suspension
Oral tablet, chewable

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

0.25 hours

15 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Drug Interactions

A total of 762 drugs are known to interact with Fosphenytoin:

230 major drug interactions (651 brand and generic names)
501 moderate drug interactions (3146 brand and generic names)
31 minor drug interactions (176 brand and generic names)

A total of 859 drugs are known to interact with Phenytoin:

243 major drug interactions (683 brand and generic names)
570 moderate drug interactions (3674 brand and generic names)
46 minor drug interactions (289 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using fosphenytoin together with alcohol may alter the effects of fosphenytoin. Contact your... View more

Phenytoin levels may decrease when the suspension is given with enteral feedings. This could lead... View more
Using phenytoin together with alcohol may alter the effects of phenytoin. Contact your doctor if... View more

Disease Interactions

First Approval Date

N/A

January 06, 1953

WADA Class View classifications

N/A

More Information

Patient Resources

Phenytoin uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Fosphenytoin vs Phenytoin

See also:

Lamictal

Carbamazepine

Ozempic

Levetiracetam

Lyrica

Topiramate

Diazepam

Pregabalin

Lorazepam

Clonazepam

Further information

Comparing Fosphenytoin vs Phenytoin

See also:

Further information

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