Comparing Differin vs Tretinoin Topical
| Differin (adapalene) | Tretinoin topical |
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| Differin (adapalene) | Tretinoin topical |
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Prescription and OTC
Prescribed for Acne. Differin may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Photoaging of the Skin, Lichen Sclerosus, Acne, Necrobiosis Lipoidica Diabeticorum. Tretinoin topical may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Differin (adapalene) | More about Tretinoin topical | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Differin has an average rating of 6.1 out of 10 from a total of 346 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 36% reported a negative effect. |
Tretinoin topical has an average rating of 7.7 out of 10 from a total of 493 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 14% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Differin side effects |
View all Tretinoin topical side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Differin prices |
View all Tretinoin topical prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other adapalene brands include: Plixda | Altinac, Altreno, Atralin, Avita, Obagi, Refissa, Renova, Retin A Micro, Retin-A, Retin-A and Renova View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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51 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 12 drugs are known to interact with Differin:
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A total of 12 drugs are known to interact with Tretinoin topical:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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May 31, 1996 |
January 26, 1973 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.