Comparing Depo-Provera vs Skyla
| Depo-Provera Remove Depo-Provera from your drug comparison | Skyla Remove Skyla from your drug comparison |
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| Depo-Provera medroxyprogesterone Remove Depo-Provera from your drug comparison | Skyla levonorgestrel Remove Skyla from your drug comparison | ||||||||
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Prescribed for Abnormal Uterine Bleeding, Amenorrhea, Endometrial Cancer, Endometrial Hyperplasia - Prophylaxis, Birth Control, Endometriosis. Depo-Provera may also be used for purposes not listed in... View more |
Prescribed for Birth Control. Skyla may also be used for purposes not listed in this medication guide. |
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Prescription only |
Prescription only |
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Ratings & Reviews |
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Drug Class |
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Side Effects |
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See the full Depo-Provera side effects document. |
Common side effects include: amenorrhea. See the full Skyla side effects document. |
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Pricing and Coupons* Prices are without insurance |
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Skyla prices and generic prices |
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Generic Availability |
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Dosage Form(s) Available |
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Brand Names |
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| Other medroxyprogesterone brands include: depo-subQ provera 104, Provera | Other levonorgestrel brands include: Aftera, AfterPill, AfterPlan, Athentia Next, BionaFem, EContra EZ, EContra One-Step, Fallback Solo, Kyleena, Liletta, Mirena, Morning After, My Choice, My Way, New Day, Next Choice One Dose, Opcicon One-Step, Option 2, Plan B One-Step, PostDay One-Step, Preventeza, React, Take Action View more | ||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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401 hours |
45 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
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Drug Interactions |
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A total of 205 drugs are known to interact with Depo-Provera:
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A total of 216 drugs are known to interact with Skyla:
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Alcohol/Food/Lifestyle Interactions |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions |
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First Approval Date |
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September 23, 1960 |
N/A |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.