Comparing Depo-Provera vs Skyla
Depo-Proveramedroxyprogesterone |
Skylalevonorgestrel |
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Prescribed for Abnormal Uterine Bleeding, Birth Control, Amenorrhea, Endometriosis, Endometrial Hyperplasia - Prophylaxis, Endometrial Cancer. Depo-Provera may also be used for purposes not listed in... more |
Prescribed for Birth Control. Skyla may also be used for purposes not listed in this medication guide. |
Choose a suggestion belowBirth Control (Contraception)
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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4.6
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7.1
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Drug Class |
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Side Effects |
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See the full Depo-Provera side effects document. |
Common side effects include: amenorrhea. See the full Skyla side effects document. |
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Pricing and Coupons* Prices are without insurance |
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Generic Availability |
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Dosage Form(s) Available |
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Brand Names |
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Other medroxyprogesterone brands include: Depo-Provera Contraceptive, depo-subQ provera 104, Provera | Other levonorgestrel brands include: Aftera, AfterPill, Athentia Next, EContra EZ, EContra One-Step, Fallback Solo, Her Style, Kyleena, Liletta, Mirena, Morning After, My Choice, My Way, New Day, Next Choice, Next Choice One Dose, Opcicon One-Step, Option 2, Plan B, Plan B One-Step, Preventeza, React, Take Action more... | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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401 hours |
45 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
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FDA Alerts |
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N/A |
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Drug Interactions |
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A total of 255 drugs are known to interact with Depo-Provera:
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A total of 278 drugs are known to interact with Skyla:
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Alcohol/Food/Lifestyle Interactions |
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No results found - however, this does not necessarily mean no warnings exist. Always consult with your doctor or pharmacist. |
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Disease Interactions |
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First Approval Date |
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September 23, 1960 |
N/A |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Birth Control I got on the Depo shot January 2016. I gained 20 pounds my first couple of months, but that was in combination with the fact it was my freshmen year of college & I ate a lot of fried food. For the first year everything was great- no periods at all! I got on depo because my body rejected contraceptive pills because of the estrogen levels. In February 2017 I had a ruptured ovarian cyst. I didn’t know they could hurt that bad! For the first 24 hours with the severe pain it was so bad on my right side I thought it was my appendix! But then I bled and yeah. Then March 2018 I got diagnosed with 3 more ovarian cysts, one being 10cm, so I had to get it surgically removed. I also get spotting every week before my depo shot is due. Overall, if you really don’t want to get pregnant, the shot is great because I never have to worry about remembering a pill & it is SUPER effective!!!! But it has caused a lot of problems with my ovaries & my OBGYN wants me off of it this year & on something else