Comparing Depo Provera vs Skyla

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Depo Provera (medroxyprogesterone)	Skyla (levonorgestrel)	Enter another drug to compare

Depo Provera (medroxyprogesterone)

Skyla (levonorgestrel)

Prescription only

Prescribed for Birth Control. Depo Provera may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Birth Control. Skyla may also be used for purposes not listed in this medication guide.

More about Depo Provera (medroxyprogesterone)

More about Skyla (levonorgestrel)

Ratings & Reviews

Depo Provera has an average rating of 4.2 out of 10 from a total of 1969 ratings on Drugs.com. 27% of reviewers reported a positive effect, while 55% reported a negative effect.

Skyla has an average rating of 6.9 out of 10 from a total of 1537 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 1969 reviews

View all 1537 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Bleeding (46.2%)
Weight gain (25.7%)
Spotting (18.3%)
Mood swings (16.6%)
Cramps (16.3%)
Depression (14.5%)
Acne (10.8%)

View all Depo Provera side effects

Cramps (71.4%)
Pain (25.7%)
Spotting (23.8%)
Bleeding (19.0%)
Acne (13.2%)
Weight gain (10.7%)
Mood swings (7.6%)

View all Skyla side effects

Drug Class

Generic Availability

Lower cost generic approved

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	1 mL
Strength	150 mg/mL
Per unit^*	$66.19
Cost^*	$66.19

View all Depo Provera prices

Quantity	1 device
Strength	13.5 mg
Per unit^*	$1,089.67
Cost^*	$1,089.67

View all Skyla prices

Get free Discount Card

Dosage Forms

Intramuscular suspension

Intrauterine device

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

401 hours

45 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 254 drugs are known to interact with Depo Provera:

43 major drug interactions (113 brand and generic names)
203 moderate drug interactions (651 brand and generic names)
8 minor drug interactions (56 brand and generic names)

A total of 261 drugs are known to interact with Skyla:

60 major drug interactions (162 brand and generic names)
187 moderate drug interactions (645 brand and generic names)
14 minor drug interactions (65 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You... View more

Disease Interactions

First Approval Date

September 23, 1960

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Depo Provera uses

Skyla uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Depo Provera vs Skyla

See also:

Provera

Nexplanon

Dupixent

Slynd

Yaz

Mirena

Sprintec

Lo Loestrin Fe

Yasmin

Drospirenone

Further information

Comparing Depo Provera vs Skyla

See also:

Further information

Compare Drugs