Comparing Contrave vs Zepbound
| Contrave (bupropion / naltrexone) | Zepbound (tirzepatide) |
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| Contrave (bupropion / naltrexone) | Zepbound (tirzepatide) |
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Prescription only
Prescribed for Weight Loss (Obesity/Overweight). Contrave may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Weight Loss (Obesity/Overweight), Obstructive Sleep Apnea/Hypopnea Syndrome. Zepbound may also be used for purposes not listed in this medication guide. |
Related suggestions Weight Loss (Obesity/Overweight)
Popular comparisons
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| More about Contrave (bupropion / naltrexone) | More about Zepbound (tirzepatide) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Contrave has an average rating of 6.6 out of 10 from a total of 1988 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 25% reported a negative effect. |
Zepbound has an average rating of 8.9 out of 10 from a total of 298 ratings on Drugs.com. 86% of reviewers reported a positive effect, while 1% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Contrave side effects |
View all Zepbound side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Contrave prices |
View all Zepbound prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
Other tirzepatide brands include: Mounjaro | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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21 hours |
120 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 758 drugs are known to interact with Contrave:
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A total of 414 drugs are known to interact with Zepbound:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 10, 2014 |
N/A |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.