Vedolizumab and Chills: What Users Say

• Pea...
• March 12, 2021

Vedolizumab for Ulcerative Colitis "I’ve had UC for 37 years. I’ve been on Entyvio for 12 months. I chose to stop due to the debilitating side effects. I am in remission now, however, the side effects are not worth it. After my first infusion, I felt I was having a heart attack. The EMTs said my heart was fine, but I was close to having a stroke. Cortisone injections eliminated this symptom. Over 8 treatments, I developed severe bone and joint pain, some hair loss, major skin dryness and bruising, extreme fatigue, extreme chills and sweats, mouth sores constantly, 24/7 nausea and loss of appetite, some tremors, depression, boils appeared including around my eyes. I developed a serious eye infection after the 8th injection. The ophthalmologist said he’s only seen this type of eye infection in chemo patients. My olfactory senses became affected. Food started tasting different and fragrances seemed off. Entyvio did work, but it’s clearly a toxic drug to where the quality of life is impacted severely in my case."

• CLa...
• Taken for 1 to 2 years
• September 18, 2019

Vedolizumab for Ulcerative Colitis "I have suffered from UC for 14 years. I have tried everything, and it would work for a short while, and then I flared up again. Remicade gave me bad side effects. I stopped and tried good diets and natural means for a year. I had an infection that caused my UC to come back, and I was very sick for a few months. My doctor put me on Entyvio, and it took three or four months for the medicine to work. I have been taking it every four weeks for a year, and now I feel excellent. I have not felt this good in years. For side effects, I had one terrible headache, and sometimes it feels like I have a cold. I always lost a lot of hair with prednisone, and after flares, I have my hair back now, gained weight, and feel very strong."

• JDa...
• August 19, 2019

Vedolizumab for Crohn's Disease "My Crohn's was diagnosed in 1978. Started Entyvio in June 2019. Have had the 3 loading doses and am now on the 8-week infusion schedule. Although my Crohn's symptoms have abated, I am experiencing unpleasant side effects: constant joint pain, especially in the neck and shoulders; severe headaches; blurred vision; cuts not healing; hot flashes; chills. Not happy about the side effects, but they are better than the severe abdominal pain and diarrhea."

• SZ0...
• Taken for 6 months to 1 year
• October 16, 2018

Vedolizumab for Crohn's Disease "I've been on Entyvio now for nine months. Since I've been on the medicine, I only experience Crohn's symptoms about once every week and a half in the evening around bedtime. At that time, I have diarrhea, but after emptying, I feel fine. I no longer am concerned about going out and eating or leaving the house and having an emergency with diarrhea; however, for the last two weeks plus, I've been fighting cold symptoms, and although I may be a little better, I am beginning to wonder if I will ever get over the cold. After reading the experiences of others, I am wondering if the Entyvio is complicating my recovery."

• Jay...
• Taken for 1 to 6 months
• September 16, 2020

For Ulcerative Colitis "Started this drug, vedolizumab, in June 2020 after being hospitalized due to a bad flare-up of Ulcerative Colitis. Was put on 40 mg pred and had first vedolizumab infusion. Came off steroids in August '20 and have been steroid-free. My symptoms have improved a lot, I just get abdominal pains, which I can manage. However, the side effects of vedolizumab have been pretty bad. At first, I had really bad joint pains, especially in my ankles, wrists, and back. Then the fatigue was really bad, I still feel very tired. I have good days and bad ones. I also get random attacks of cold and runny nose. I also get strange chest tightness, had a CT and X-ray, all fine, so I can only assume it's a side effect of vedolizumab. Although vedolizumab has helped my UC a lot, the side effects have been pretty awful. I'm just doing my best to stick it out in the hope that the side effects will wear off with time. My advice: give it a try if nothing else has worked."

• Ano...
• Taken for 6 months to 1 year
• June 22, 2025

Vedolizumab for Crohn's Disease "I had minor side effects when I had the initial load doses (fatigue, numb feeling in my mouth), however, when I then switched to the injections at home, the 3rd one left me feeling very sick with fever and chills for 2 days. After consulting with my doctor, we decided we’d go back to the infusions along with taking an allergy medication and steroid before my injection to reduce the risk of a serious allergic reaction. The reason why we decided to give this a try was because my inflammation was reduced to the lowest it had been in 6 years! That’s after trying various other biologics. Given the significant improvement, we decided it was worth at least trying to see if the infusions avoided the side effects I had with the last injection."

• The...
• Taken for 1 to 2 years
• March 8, 2017

Vedolizumab for Crohn's Disease "Stayed on it for over a year. Took in combination with Entocort. Saw little to no improvement. Gave significant side effects such as flushing, fevers, nausea, chills, severe migraines, etc."