Zepbound User Reviews & Ratings

• DRo...
• Taken for 1 to 6 months
• February 8, 2025

For Weight Loss (Obesity/Overweight) "I started on Zepbound 2.5 back in Dec 2024. No major issues in the beginning. It definitely helps control your appetite, and you feel sick if you eat too much. After going to 5.0, I got a little more nauseated and started noticing more dizziness, lightheadedness, and fatigue. But I was losing the weight, so I just kept going. After going to 7.5, that's when my horror stories started. I have taken only two doses but am stopping this stuff altogether. It has truly caused me extreme dizziness, shortness of breath, fatigue, terrible stomach pains, and diarrhea that won't stop. I have lost 37 pounds... great... but the suffering and pain that comes with this medicine... no thanks. I'd rather be a little overweight and be happy than the constant nausea, stomach pain, and diarrhea. Best of luck to you all, but I'm going to accept me for me."

• Xer...
• Taken for 1 to 6 months
• May 21, 2025

For Weight Loss (Obesity/Overweight) "Second review. I'm male, 75 years old. Began taking 2.5 mg on January 12, 2025. Today is May 21, 2025. Weight dropped from 268 to 232.5 (35.5 lbs). Went to 10 mg on May 8. Took 2 weekly 10.0 doses in that time period. Suddenly, explosive diarrhea, sulfur burps, nausea, and fatigue began May 18. My PA has advised not taking my 10.0 injection tomorrow (my regular day). Think I may need to drop back to 7.5 — had no side effects at that level (or at 2.5 or 5.0). Had already decided not to go to 12.5 because I have a friend who was fine on 10.0 but encountered major side effects at 12.5. Still, even 10.0 may not be right for me. The weight loss is stunning; haven't been at this level in over five years — but for a BMI of 25, I still have over 70 lbs to go, so I don't want to abandon Zepbound altogether. It may take longer to get there, but that's fine if it means I can avoid side effects."

• Krg...
• Taken for less than 1 month
• February 4, 2025

"Follow Up: I am currently on day 11 of Zepbound 2.5 mg. As of this morning, I have lost 11.73 lbs. Daily, I documented how I felt and symptoms. The first 24 hours of injection #1, I had extreme fatigue, normal appetite, and a whole lot of belching. Day 2, belching, less hungry, no other symptoms. Day 3, I had no appetite, no other symptoms. Day 4, less than normal appetite, no other symptoms . Days 3 and 4 have just been repetitive. I have had no negative side effects, BUT I also have made sure to eat high-protein foods for every meal, even on the days I had no appetite, nothing greasy (thinking about it turns my stomach), no high-sugar foods. As of today, I’d say; if you work with the medication, the medication will work with you. Update you in a couple of weeks."

• Ree...
• Taken for 1 to 6 months
• March 15, 2024

For Weight Loss (Obesity/Overweight) "Was on Wegovy 2 months (PsA weight loss need) - horrible. Lost 18 pounds but got depression, which is odd for me as I have never had it. Once off it, about 3 weeks, I was fine. Decided to give ZepBound a try, a friend had great success with Monjouro (diabetic), when this came out, I was approved. Having a friend with experience really helped to get me through the first 3 weeks. They were rough. But I knew to stay away from meats for 5 days after shot and ANYTHING with fat or oil - it will not digest. 2 days after the shot are the hardest as far as digestion, eat very small, eat early or reflux will occur. My 'go to' is a cup of mac & cheese, half a bagel (plain) or berries (apples indigestible). No variety for me on this. Menthol cough drop a lifesaver - soothes my stomach. Sugars OK. Diarrhea from some foods, turned to some constipation after 2 months. Lost 27 pounds in 3 months, the fatigue is my worst side effect. Find your digestible foods, stick with them, exclusively."

• Sus...
• Taken for 1 to 6 months
• March 26, 2024

For Weight Loss (Obesity/Overweight) "I've been on Zepbound for about 3 months. I'm 5'3' and started at 167. So far I have lost 12 lbs. trying to maintain a 1,200 calorie diet. The main thing is to watch what you eat and quit when you are full. The only side effects I've seen are fatigue and constipation. The shots don't bother me at all and no nausea, thank goodness. The only thing I'm really worried about is gaining it back when I stop. Good luck to all!"

• Mik...
• Taken for 1 to 6 months
• January 15, 2024

For Weight Loss (Obesity/Overweight) "I’m a 6’4", 275-pound male, 62 years old - no diabetes or health issues, on no other meds. Obtained prescription via Dr. and took the first 2.5 mg injection on Dec. 24. Lost 10 pounds with the first 3 shots, then Dr. said I could go to 5 mg (saved the last 2.5 mg pen for future use) because weight loss had stopped. After starting 5 mg, lost 2 pounds in 2 days - so combined weight loss using 2.5/5 mg is now at 12 pounds in six weeks! No significant or terrible side effects except some constipation, intermittent fatigue, and minor chills at times (not a lot - could just be the cold weather). I've yo-yoed up and down with weight for years. Because of my size, I can eat a lot of food - but this drug has significantly reduced my appetite, and I have more energy overall. I can’t wait to see the results in a few more months. Zepbound has so far been perfect for me. I don’t mind the $550 price (with the Lilly savings card - has been hard to get CVS to make it work, but that’s another story/nightmare)."

• ali...
• Taken for 1 to 6 months
• April 29, 2024

For Weight Loss (Obesity/Overweight) "Started at the end of Jan 24. 4 weeks at 2.5mg, 8 weeks at 5mg due to lack of supply. I've had to seek alternatives due to the shortage of this drug, but it is worth it. I've lost 30 pounds in 14 weeks and moved up to 7.5mg on my last dose. The food noise is gone. The alcohol noise is gone. Other than some nausea and fatigue on shot day, side effects have been mild and easily manageable. I wish I'd have been able to start this long ago and gotten my life back. 30 pounds to go and I have no doubt I will be successful."

• Dee...
• Taken for 1 to 6 months
• April 6, 2025

For Weight Loss (Obesity/Overweight) "I started in January and have moved doses up monthly. This morning I took my 4th 7.5 mg dose. I did have a 2.5 mg pen malfunction and moved up to 5 a week early. I've been losing 1-3 pounds a week, for a total today of 28 lb loss. My goal is to lose 50. As far as side effects, they really aren't too bad for me. Daily Colace helps any constipation, which has not been much of an issue anyway. Occasional nausea is fleeting and is helped with Coke One. I know some are against drinking soda, but Coke One does not have sugar and has been my nausea cure for as long as it's been on the market. My appetite is diminished, but not gone. I've changed my eating pattern to several small, healthy mini-meals during the day instead of 3 'regular' meals. Zero cravings for junk food or much snacking at all. Part, I'm sure, is that I'm keeping those mini meals full of protein and vegetables. The only real issue that I've had is fatigue. It hits about an hour after the shot and lasts about 36 h."

• Ano...
• Taken for 1 to 6 months
• May 28, 2025

For Weight Loss (Obesity/Overweight) "I love Zepbound. I was on Wegovy prior to switching to Zepbound and lost 20 pounds in 6 months. I was nauseous, fatigued, and dizzy for 3-4 days after taking my shot. However, on the Zepbound, I have no side effects other than slight pain at the injection site for 2-3 minutes after I take my shot. After switching to Zepbound, I lost another 20 pounds in just 3 months."

• Lis...
• Taken for less than 1 month
• May 19, 2025

For Weight Loss (Obesity/Overweight) "I just started taking Zepbound for less than a week now. I am 5 days in. I have not had any major side effects. I have felt very little nausea at times. I had a very mild tummy ache a couple of times. I felt a little dizzy the first day and then nothing after that. I felt very fatigued the third day but have been good since. I have lost 4 lbs so far. I am 5' 2" and weighed 161. I am down to 157 as of today (5th day). My goal is 130 at least. I don't feel hungry. I don't think about snacking. I forget to eat most of the time because I am not hungry. I have to remind myself to eat something. I eat very small portions and feel satisfied. I am loving this! I do recommend it to anyone wanting to lose weight."

• Bye...
• Taken for 1 to 6 months
• July 23, 2025

For Weight Loss (Obesity/Overweight) "Lifelong dieter here. Despite successes, the weight always crept back. Zepbound feels like a game changer thus far. I feel fabulous overall. Nobody knows of my decision to try Zep, yet already everywhere I go people comment on how healthy I look. I’m 73 years old, female, 5’6”, SW 185 and goal 145. I’m on my fifth week @2.5, with a steady loss of 2 lbs per week. Minor nausea on injection day with the abdominal injection. The tartness of gummy fiber/vitamins is great for relieving nausea. Periodic fatigue mostly on day two. Friday is injection day so I can crash on Saturday if necessary. I eat six small meals each day and try to get a total of 120-140 grams per day. I get food noise, but it’s good noise thinking about nutrient-dense and low-cal foods. Protein/collagen powders/snacks are essential to keeping healthy muscles, hair, skin. Drink water!!!"

• Ano...
• Taken for 1 to 6 months
• May 14, 2025

For Weight Loss (Obesity/Overweight) "I started on Friday, March 21, and had no side effects for the first two weeks. Then I overate cheesy pasta and had severe diarrhea. The next 10 days, I had three more episodes of diarrhea and vomiting. And severe fatigue. I was not able to continue my exercise routine as often as usual. The fatigue after minimal activity was interfering with my life. I cannot walk more than a few blocks. I stopped the injections three weeks ago, and for the most part, I have intermittent fatigue. It apparently takes about 25 days for the med to be out of the system. I lost 9 pounds after the first 3 or 4 weeks and have not gained them back. I didn't have quite the same separation of thoughts of food as I had expected. Hopefully, only another week or two to get my energy back."

• Mil...
• Taken for 6 months to 1 year
• December 1, 2024

For Weight Loss (Obesity/Overweight) "I started Zepbound in April 2024 at 193 lbs. It’s December 2024, I’m now 140 lbs. I have stayed at the 10 mg dose for almost 3 months now, as I am trying to tone my body since I lost 50 lbs fast. The side effects suck when I go up a dose, but my body adjusts after 4 weeks, so it’s been great. I have noticed that I wake up with hunger pains now, but my plan is to get used to them again before I start weaning off the drug. Side effects for me include headaches and fatigue. It’s not that bad after a while, the main thing is being strategic and proactive about getting your fiber, protein, and water in. I haven’t been to the gym since I started the 10 mg, and I’ve slowed down on the weight loss (which I’m okay with). I like 140, I’m just trying to tone now, so when I wean off, it won’t all come back. I’ll update you guys in a couple of months."

• On...
• Taken for less than 1 month
• February 18, 2025

For Weight Loss (Obesity/Overweight) "With the initial injection of 2.5 taken before bed. I woke up with painful, swollen neck lymph nodes and extreme fatigue. The next day, the swollen lymph nodes seemed to have moved down, now in the chest/armpit area. On the 3rd day, one of my knees is swollen and horribly painful. I have absolutely never had any knee issues prior to the injection. If I get nauseous, drinking more water helps. At this start of the med, continuing is definitely not worth it."

• Kat...
• Taken for 6 months to 1 year
• July 11, 2024

For Weight Loss (Obesity/Overweight) "Zepbound (tirzepatide) is amazing - if you are not losing much on semaglutide, see if your doctor will let you try tirzepatide. I’ve been on Zepbound seven months and I’m down 55 pounds. Took 2.5mg the first month and then spent 5 months on 5mg. Just moved up to 7.5mg this month and it has totally killed my appetite. Main side effect for me is fatigue, especially the day of the shot and the next couple of days. I plan to stay on 7.5 until I reach my goal weight and then go on maintenance. I will have to keep taking it - otherwise it is likely I will gain all the weight back. Yes, it is expensive but worth it."

• My...
• Taken for 1 to 6 months
• April 22, 2024

For Weight Loss (Obesity/Overweight) "Since starting Zepbound 13 weeks ago to shed 60 pounds, I've gradually increased from 2.5 mg to 10 mg. It's effective, but sleepless nights have become my unwelcome companions, especially on the higher doses. Heartburn and that uncomfortable chest sensation are no picnic either. Despite dropping 30 pounds, I feel drained—fatigue, dizziness, and concentration issues plague me. To tackle these side effects, I'll either stick to 10 mg or drop to 7.5 mg. But with a $1,000 monthly price tag and the hassle of hunting down my prescription, quitting Zepbound crosses my mind. Yet, the thought of returning to the weight loss battle isn't enticing either. Swapping out heavy meals for light options like chicken and soups helps ease discomfort, but what I really crave is a solid night's sleep. I'm giving it one last shot, tweaking my diet and powering through my remaining doses before deciding—is it worth it?"

• Ano...
• Taken for 1 to 6 months
• July 17, 2025

For Weight Loss (Obesity/Overweight) "I have lost 20 lbs in 3 1/2 months on Zepbound taking 2.5, 5.0, and 7.5 mg so far as per plan and dosage increases. I plan to use 5 mg for maintenance dosage now that I am almost at my goal weight. It is very simple to use. I had some GERD, nausea, and adjustments to make with certain foods, but that subsided after the first few months. You definitely cannot overeat as you will not feel well. The exhaustion and body aches are what bother me the most. For the first 3 days after an injection, I am so tired that it impacts what I can get done in a day, including energy to exercise and do my job during the day. I am sleeping okay with it, but the fatigue is almost debilitating."

• Lis...
• Taken for 6 months to 1 year
• March 29, 2025

For Weight Loss (Obesity/Overweight) "Best method for weight loss and keeping the weight off. I've lost over 100 lbs and am finally comfortable in my skin again. When you change mg dosage, fatigue could be concerning, and it does happen. Working out helps, making sure you stay hydrated, and working out was the biggest help for me. I did have constipation, and it was managed. I did have hair thinning and started taking Nutrafol. I've struggled with my weight my entire life. Not anymore. I wish we could add photos, but we can't. Portion food sizes of what you can eat are minimized. The sugar cravings were gone. Not only did those cravings disappear, but so did the cravings for food that your body turns to sugar. For example, I haven't eaten a potato chip in over 7 months. No desire for breads, mayo, Miracle Whip, and numerous other things. I FEEL so much better. It is costly, but so is poor health and obesity. I wish big pharma would realize how many Americans struggle with obesity and cover this through insurance."

• Day...
• Taken for less than 1 month
• February 2, 2025

For Weight Loss (Obesity/Overweight) "Flu-like symptoms, nausea, discomfort after eating anything. Broth has been my go-to. Very fatigued. Hoping week 2 will be better. Today is day 7. No appetite, no energy. There's not an option for maybe. One week isn’t enough time to give recommendations."

• Phi...
• Taken for less than 1 month
• June 21, 2025

For Weight Loss (Obesity/Overweight) "Only two weeks into it (2nd shot) but working, do not feel hungry, eat small portions and eating because I know I need to. Do have to take a laxative as I get constipated, day after shot do feel some fatigue and take a nap in the afternoon."

• kan...
• Taken for 1 to 6 months
• December 21, 2024

For Weight Loss (Obesity/Overweight) "I am a 55-year-old female, 5’7 starting weight 250, started Zepbound 6 weeks ago. 1st month, 2.5 — moved up to 5 2nd month. Probably the most annoying, almost immediate side effects were GERD, bloating, and constipation. However, this did improve quickly when I added more fiber, avoided high-fat, saucy foods, and ate less. I do agree with the others… that it definitely helps your “hunger-food brain.” I can skip a meal without even noticing. I fill up eating a quarter to half of what I would normally eat. I begin getting nauseated while I eat, which makes me stop eating, of course. Now that I've increased from 2.5 to 5, the nausea is a little worse, but intermittent and tolerable. Hoping this will improve once my body adjusts. Overall, still very thankful for this opportunity to try Zepbound. I'm trying to find some type of a meal plan to follow, with sufficient protein and fiber, as well as other foods or supplements to prevent muscle loss, hair loss, constipation, and fatigue."

• 2go...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "On week 5 of Zep. Goal to lose 20-25 lbs. Received a 2.5 mg 'loading' dose, I split it into 1.25 doses 3 days apart for the first 2 weeks as I tend to react strongly to meds. I had a bit of anxiety and fatigue on this dose and appetite suppression that waned by week 2, so I increased to 2.5 in one shot for weeks 3 and 4. Less anxiety/fatigue but more nausea and constipation, still manageable. I received a 5 mg dose in the mail at week 4 but had already lost 15 lbs on the 2.5 dose for 4 weeks. Week 5 - I tried the 5 mg. The next day, I was so sick to my stomach and nauseous that I struggled to eat or drink at all. I was dizzy and felt terrible, depressed, and kept getting the long bouts of hiccups. I will be at goal soon and plan to switch to metformin to maintain weight. For me, this med is miraculous, but I do not feel great on it. (For reference - I have a mental health diagnosis and pre-existing mild gastrointestinal issues, MTHFR gene variant)"

• Lis...
• Taken for 1 to 6 months
• March 5, 2025

For Weight Loss (Obesity/Overweight) "My experience is a lot better than I was expecting. I'm on the 2.5 mg a week. So far, the side effects are manageable. I barely get nauseous, but the constipation is real. I really like the once-a-week dosage because I don't particularly care for needles. My weight loss is slow, mainly due to a lack of working out. I'm extremely fatigued and just want to rest. The fatigue hits me early in the morning and late in the afternoon. Stay hydrated!"

• Pro...
• Taken for 6 months to 1 year
• February 25, 2025

For Weight Loss (Obesity/Overweight) "I’ve been on Zepbound since 8/1/24 (305 lbs, 5’6). So far, I lost 65 lbs, I’m 45 lbs away from my goal. My current dose is 10 mg. I experience side effects within 24 hours of injection administration, ranging from nausea, vomiting, belching, diarrhea, abdominal pain, fatigue, and dizziness. The side effects last about 24-36 hours. The medication definitely decreases my appetite and cravings. My doctor stopped my BP medication as I continue losing weight and my BP readings are good. My husband has noticed that I stopped snoring, lol. My plan is to reach my weight goal and stop the medication. I have changed my relationship with food. I look at food more as fuel for my body instead of indulging and overeating. I also introduced portion control and exercise, mostly walking and swimming. My insurance covers the medication."

• Ano...
• Taken for 1 to 6 months
• July 26, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "My stats on the front end of the Zepbound medication were 293 lbs at 6 feet tall. BMI was well over 40. I had constant fatigue and didn't sleep well (I am also on a CPAP). I started on 0.25 mg for 1 month and lost about 6 lbs. I then went to 0.5 mg for the past two months and have lost 18 lbs for a total of 24 lbs in 3 months. I have asked to go to 7.5 mg to help me get to my weight loss goal. My main side effect has been constipation, Miralax is helping with that. I also run 4 times a week, and exercise is very important when on Zepbound."