Zepbound and Diarrhea: What Users Say

• DRo...
• Taken for 1 to 6 months
• February 8, 2025

For Weight Loss (Obesity/Overweight) "I started on Zepbound 2.5 back in Dec 2024. No major issues in the beginning. It definitely helps control your appetite, and you feel sick if you eat too much. After going to 5.0, I got a little more nauseated and started noticing more dizziness, lightheadedness, and fatigue. But I was losing the weight, so I just kept going. After going to 7.5, that's when my horror stories started. I have taken only two doses but am stopping this stuff altogether. It has truly caused me extreme dizziness, shortness of breath, fatigue, terrible stomach pains, and diarrhea that won't stop. I have lost 37 pounds... great... but the suffering and pain that comes with this medicine... no thanks. I'd rather be a little overweight and be happy than the constant nausea, stomach pain, and diarrhea. Best of luck to you all, but I'm going to accept me for me."

• Xer...
• Taken for 1 to 6 months
• May 21, 2025

For Weight Loss (Obesity/Overweight) "Second review. I'm male, 75 years old. Began taking 2.5 mg on January 12, 2025. Today is May 21, 2025. Weight dropped from 268 to 232.5 (35.5 lbs). Went to 10 mg on May 8. Took 2 weekly 10.0 doses in that time period. Suddenly, explosive diarrhea, sulfur burps, nausea, and fatigue began May 18. My PA has advised not taking my 10.0 injection tomorrow (my regular day). Think I may need to drop back to 7.5 — had no side effects at that level (or at 2.5 or 5.0). Had already decided not to go to 12.5 because I have a friend who was fine on 10.0 but encountered major side effects at 12.5. Still, even 10.0 may not be right for me. The weight loss is stunning; haven't been at this level in over five years — but for a BMI of 25, I still have over 70 lbs to go, so I don't want to abandon Zepbound altogether. It may take longer to get there, but that's fine if it means I can avoid side effects."

• Ano...
• Taken for 1 to 6 months
• May 14, 2025

For Weight Loss (Obesity/Overweight) "I started on Friday, March 21, and had no side effects for the first two weeks. Then I overate cheesy pasta and had severe diarrhea. The next 10 days, I had three more episodes of diarrhea and vomiting. And severe fatigue. I was not able to continue my exercise routine as often as usual. The fatigue after minimal activity was interfering with my life. I cannot walk more than a few blocks. I stopped the injections three weeks ago, and for the most part, I have intermittent fatigue. It apparently takes about 25 days for the med to be out of the system. I lost 9 pounds after the first 3 or 4 weeks and have not gained them back. I didn't have quite the same separation of thoughts of food as I had expected. Hopefully, only another week or two to get my energy back."

• Pro...
• Taken for 6 months to 1 year
• February 25, 2025

For Weight Loss (Obesity/Overweight) "I’ve been on Zepbound since 8/1/24 (305 lbs, 5’6). So far, I lost 65 lbs, I’m 45 lbs away from my goal. My current dose is 10 mg. I experience side effects within 24 hours of injection administration, ranging from nausea, vomiting, belching, diarrhea, abdominal pain, fatigue, and dizziness. The side effects last about 24-36 hours. The medication definitely decreases my appetite and cravings. My doctor stopped my BP medication as I continue losing weight and my BP readings are good. My husband has noticed that I stopped snoring, lol. My plan is to reach my weight goal and stop the medication. I have changed my relationship with food. I look at food more as fuel for my body instead of indulging and overeating. I also introduced portion control and exercise, mostly walking and swimming. My insurance covers the medication."

• Mk6...
• Taken for 1 to 6 months
• March 10, 2025

For Weight Loss (Obesity/Overweight) "I started in January 2025 with the 2.5 dose. For the first two weeks, I experienced nausea and diarrhea off and on. For the last two weeks, I was fine. I am on my second week of 5 mg. The first week, I was so sick - I take the shot late Friday afternoon - I was in bed most of the day on Saturday with nausea and fatigue. I did vomit once. Sunday was the same. The rest of the week, I felt fine. Second shot last Friday - I was okay on Saturday - able to function but very nauseous. Woke up on Sunday and spent most of the day in bed due to nausea and fatigue. The anti-nausea medicine helps but not so much for me. Today I am functioning with some nausea. The benefits of this drug are obvious. I don't eat as much as I did before the medicine. I've lost 16 lbs so far. The nausea bothers me. I should be able to function and not get sick every weekend after a shot. I no longer have diarrhea - I am constipated instead. When I take Miralax, I cannot think about it or I get sick."

• kin...
• Taken for 1 to 6 months
• May 19, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Caused diarrhea, fatigue, kidney problems on lowest dosage for 4 months."

• Oti...
• Taken for less than 1 month
• April 20, 2025

For Weight Loss (Obesity/Overweight) "Lost 5 lbs the first week. Lots of diarrhea. Feeling fatigue fairly often. Rarely feel hungry. Easy to go most of the day without eating."