Zepbound User Reviews & Ratings (Page 2)
Zepbound has an average rating of 8.8 out of 10 from a total of 431 reviews on Drugs.com. 82% of reviewers reported a positive experience, while 2% reported a negative experience.
Reviews for Zepbound
- Ano...
- Taken for 1 to 6 months
- July 9, 2025
For Weight Loss (Obesity/Overweight) "So far the experience for me has been difficult. The weight loss is slow but pretty much steady. I’m experiencing nausea, stomach pain, and fatigue. I’m still trying to stick it out, hoping that it will subside."
- agm...
- Taken for 1 to 6 months
- December 18, 2024
For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 16 weeks. I have lost 23 lb. I am a 6'3" 74-year-old man. I wanted a kick start to get to my goal, which I am at. Except for three weeks at 5 mg, I have been on 2.5 and am now after a brief go at 5 mg. My experience has been generally acceptable, but nausea and fatigue are a real challenge. No vomiting or diarrhea. I have had some acid reflux. The key has been to eat good clean food and stay away from fried or greasy. I have reduced my alcohol intake, but they are empty calories, and why do it? It just makes it tougher. The reason I drink some is usually social, but I have found it easier to abstain than I expected. Here's the deal: I think people lose weight on these drugs because they don't want to get sick and choose to behave and stay at a calorie deficit, and bingo, the math kicks in. It's not rocket science. I have taken a week off while on an overseas trip. Again, I didn't want to get sick. I am about to take another week off."
Frequently asked questions
- Zepbound vs. Mounjaro: Comparison Guide for Weight Loss and Diabetes Treatment
- Ozempic Mounjaro Wegovy & Zepbound: Weight Loss Compared
- Which GLP-1 drug is best for weight loss?
- How much is Zepbound with or without insurance?
- 215...
- Taken for 1 to 6 months
- November 11, 2024
For Weight Loss (Obesity/Overweight) "First things first. I'm a 40-year-old woman. My height is 5'9", and my starting weight was 214. During my first month on Zepbound 2.5 mg, I experienced fatigue, dry mouth, and slight constipation. I'm on my second month dosage of 5 mg now, and I'm experiencing nausea and migraines. This is my sixth injection, and the weight fell off during the first month, and now I'm at a standstill. I'm weighing in at 195 for the last 2 weeks. During my first month, I had no carbs at all. I made sure I had at least 120 g of protein a day, and I weight trained four times a week, getting my goal of 10,000 steps a day. I haven't kept that same training routine these past two weeks, which is why I probably haven't lost any weight. I'd say the medicine really works. I'm not looking to stay on long-term. Since I hit 40, I've struggled with weight, perimenopause, etc. This has been a game changer."
- Mk6...
- Taken for 1 to 6 months
- March 10, 2025
For Weight Loss (Obesity/Overweight) "I started in January 2025 with the 2.5 dose. For the first two weeks, I experienced nausea and diarrhea off and on. For the last two weeks, I was fine. I am on my second week of 5 mg. The first week, I was so sick - I take the shot late Friday afternoon - I was in bed most of the day on Saturday with nausea and fatigue. I did vomit once. Sunday was the same. The rest of the week, I felt fine. Second shot last Friday - I was okay on Saturday - able to function but very nauseous. Woke up on Sunday and spent most of the day in bed due to nausea and fatigue. The anti-nausea medicine helps but not so much for me. Today I am functioning with some nausea. The benefits of this drug are obvious. I don't eat as much as I did before the medicine. I've lost 16 lbs so far. The nausea bothers me. I should be able to function and not get sick every weekend after a shot. I no longer have diarrhea - I am constipated instead. When I take Miralax, I cannot think about it or I get sick."
- Ano...
- Taken for 1 to 6 months
- August 18, 2025
For Weight Loss (Obesity/Overweight) "I have been taking Zepbound for four months and have lost 23 lbs so far. In terms of facilitating weight loss, it is a miracle drug. I eat less without feeling hungry, and I don't think about food. But there are definite side effects-diarrhea (this is the worst-can last for days), constipation (yes, the diarrhea quickly turns to constipation), heartburn (easily controlled), and some fatigue in the first 24 hours. I was on 2.5 for 1 month, then went up to 5 (ish). For me, the worst side effects kick in at 5. I am getting the medication in a vial so I can easily adjust the dose a bit. A couple of weeks ago, I went down to 4.5, and the side effects were much less severe. I'm experimenting to see where in the 4.5 to 5 range I get a balance between weight loss and side effects that I feel comfortable with. Right now, I am still losing weight. After another 10 lbs, I will be at a healthy weight and hope I can decrease the dose to maintain weight loss and reduce side effects."
- kin...
- Taken for 1 to 6 months
- May 19, 2025
For Obstructive Sleep Apnea/Hypopnea Syndrome "Caused diarrhea, fatigue, kidney problems on lowest dosage for 4 months."
More FAQ
- How long does it take for Zepbound to work?
- Can you get tirzepatide from a compounding pharmacy?
- How do Zepbound and Wegovy compare?
- Is Zepbound covered by insurance?
- Ano...
- Taken for less than 1 month
- May 14, 2025
For Weight Loss (Obesity/Overweight) "I have lost 14 lbs in 4 weeks. Extreme fatigue and a little nausea. A little shortness of breath when walking. Feeling weak."
- Mor...
- Taken for less than 1 month
- July 21, 2025
For Weight Loss (Obesity/Overweight) "So far, so good. I am suffering from the nauseated feeling, burping, fatigue, and muscle cramps. I'm at 2.5 level, week 3. I'm definitely eating a lot less."
- Ano...
- Taken for 1 to 6 months
- June 7, 2025
For Weight Loss (Obesity/Overweight) "Lost 22 pounds! But… hair started falling out and feel fatigued!"
- Oti...
- Taken for less than 1 month
- April 20, 2025
For Weight Loss (Obesity/Overweight) "Lost 5 lbs the first week. Lots of diarrhea. Feeling fatigue fairly often. Rarely feel hungry. Easy to go most of the day without eating."
See also:
More about Zepbound (tirzepatide)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Drug images
- Latest FDA alerts (2)
- Side effects
- Dosage information
- During pregnancy
- Support group
- FDA approval history
- Drug class: GLP-1 Agonists (Incretin Mimetics)
- Breastfeeding
- En español
For Weight Loss (Obesity/Overweight) "I love Zepbound as it is the only thing that has helped me lose weight easily. After reading the reviews on here, my approach has been somewhat different as I refused to give up any foods or alcohol as that isn't real life for me. I walk 4 miles a day but haven't done real cardio or weight lifting very often so that is next. I have been on it for 13 months and started at 190 and am at 152, which is less than my high school weight/5'6'' and was a college athlete, so a very muscular type build. I am ecstatic at this weight but scared to go off Zepbound as I can control my food addictions with it and don't eat 2000 calories at midnight anymore. I get full very quickly so I am eating way less than my old norm of 4000 calories a day. :-) I am at 12.5 mg and the side effects I have had are mostly fatigue and my hair breaking off. At first, I had nausea and injection site swelling, but that went away after the first month."