Zepbound and Vomiting: What Users Say

• Ano...
• Taken for 1 to 6 months
• May 14, 2025

For Weight Loss (Obesity/Overweight) "I started on Friday, March 21, and had no side effects for the first two weeks. Then I overate cheesy pasta and had severe diarrhea. The next 10 days, I had three more episodes of diarrhea and vomiting. And severe fatigue. I was not able to continue my exercise routine as often as usual. The fatigue after minimal activity was interfering with my life. I cannot walk more than a few blocks. I stopped the injections three weeks ago, and for the most part, I have intermittent fatigue. It apparently takes about 25 days for the med to be out of the system. I lost 9 pounds after the first 3 or 4 weeks and have not gained them back. I didn't have quite the same separation of thoughts of food as I had expected. Hopefully, only another week or two to get my energy back."

• Ran...
• Taken for 1 to 6 months
• May 25, 2025

For Weight Loss (Obesity/Overweight) "I started on the 2.5 mg starting dose. After the second day, I was experiencing severe diarrhea, burping, nausea. These went away on Day 6. Very tolerable after then. I stayed on 2.5 for several months before going to the 5 mg dose, due to the intensity of my side effects. Started Day 1 of the 5 mg dose, and on the 3rd day after it I had tiredness, orthostatic hypotension (85/55 when standing up). At the 5th day, I am still having orthostatic hypotension - I maintained a water source. Spent 2.5 days without eating. I also vomited a couple of times during the 5 mg startup. Once this batch of side effects goes away, probably will be fine. I just think that a warning about the SEVERE side effects that make me functionally worthless should be discussed. I believe my side effects are a little more extreme than most, but folks should, at least, be informed."

• Tim...
• Taken for 1 to 6 months
• July 27, 2024

For Weight Loss (Obesity/Overweight) "Severe nausea, horrid vomiting and diarrhea after 7.5 mg dose - did okay with 2.5 and 5 mg doses - there should be more warnings with the higher doses as this was severe. Higher doses should be reviewed further for safety reasons."

• Pro...
• Taken for 6 months to 1 year
• February 25, 2025

For Weight Loss (Obesity/Overweight) "I’ve been on Zepbound since 8/1/24 (305 lbs, 5’6). So far, I lost 65 lbs, I’m 45 lbs away from my goal. My current dose is 10 mg. I experience side effects within 24 hours of injection administration, ranging from nausea, vomiting, belching, diarrhea, abdominal pain, fatigue, and dizziness. The side effects last about 24-36 hours. The medication definitely decreases my appetite and cravings. My doctor stopped my BP medication as I continue losing weight and my BP readings are good. My husband has noticed that I stopped snoring, lol. My plan is to reach my weight goal and stop the medication. I have changed my relationship with food. I look at food more as fuel for my body instead of indulging and overeating. I also introduced portion control and exercise, mostly walking and swimming. My insurance covers the medication."

• Joa...
• Taken for less than 1 month
• November 10, 2024

For Weight Loss (Obesity/Overweight) "I'm a 64-year-old woman. 5'2" and weighed 177. I've lost 10 pounds in my first 3 weeks. With the heartburn, I had to force myself to eat last night when I wasn't really hungry. I think I ate the scrambled eggs too late in the evening. I had horrible diarrhea and vomiting. That was the first time that happened. I'm hoping it's just because I ate so late on such an empty stomach. I have had no desire to eat the first 3 or 4 days after injection. I have to remind myself to eat something."

• Xer...
• Taken for 1 to 6 months
• May 18, 2025

For Weight Loss (Obesity/Overweight) "Began taking on January 12, 2025. Moved up dosage monthly under supervision of Physician’s Assistant from 2.5 mg to 10 mg. No noticeable side effects. Lost 30 lbs between start date and May 18, 2025 (from 268 to 238 lbs). Previously tried Ozempic and Wegovy each for about two weeks each. Had horrible side effects (explosive diarrhea and vomiting) bad enough to discontinue. Was apprehensive about Zepbound — but experience was completely different. Only exception was May 17-18, when consumed about three glasses of wine (previously had no alcohol during usage period). Had explosive diarrhea just like when using Ozempic and Wegovy. Tested for COVID on May 18, but result was negative. Intend to continue with Zepbound (despite the predatory cost — over $500/month out of pocket but with some insurance). Intend to avoid alcohol consumption and see whether side effects diminish. Pleased with Zepbound results thus far."

• Mk6...
• Taken for 1 to 6 months
• March 10, 2025

For Weight Loss (Obesity/Overweight) "I started in January 2025 with the 2.5 dose. For the first two weeks, I experienced nausea and diarrhea off and on. For the last two weeks, I was fine. I am on my second week of 5 mg. The first week, I was so sick - I take the shot late Friday afternoon - I was in bed most of the day on Saturday with nausea and fatigue. I did vomit once. Sunday was the same. The rest of the week, I felt fine. Second shot last Friday - I was okay on Saturday - able to function but very nauseous. Woke up on Sunday and spent most of the day in bed due to nausea and fatigue. The anti-nausea medicine helps but not so much for me. Today I am functioning with some nausea. The benefits of this drug are obvious. I don't eat as much as I did before the medicine. I've lost 16 lbs so far. The nausea bothers me. I should be able to function and not get sick every weekend after a shot. I no longer have diarrhea - I am constipated instead. When I take Miralax, I cannot think about it or I get sick."

• Lor...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "I started on Zepbound 3 months ago. I began at 2.5 mg the first month and then went to 5 mg for 2 months. I had no side effects whatsoever. I started 7.5 mg last Sunday, and by Tuesday, I was nauseous, vomiting, and had diarrhea. It went away overnight, and now I’m fine, but not sure I want to continue with 7.5 mg due to the side effects. I have lost only 10 lbs in the 3 months I have been on it, but will have to stop taking it if these side effects continue."