Zepbound and Burping: What Users Say

• Xer...
• Taken for 1 to 6 months
• May 21, 2025

For Weight Loss (Obesity/Overweight) "Second review. I'm male, 75 years old. Began taking 2.5 mg on January 12, 2025. Today is May 21, 2025. Weight dropped from 268 to 232.5 (35.5 lbs). Went to 10 mg on May 8. Took 2 weekly 10.0 doses in that time period. Suddenly, explosive diarrhea, sulfur burps, nausea, and fatigue began May 18. My PA has advised not taking my 10.0 injection tomorrow (my regular day). Think I may need to drop back to 7.5 — had no side effects at that level (or at 2.5 or 5.0). Had already decided not to go to 12.5 because I have a friend who was fine on 10.0 but encountered major side effects at 12.5. Still, even 10.0 may not be right for me. The weight loss is stunning; haven't been at this level in over five years — but for a BMI of 25, I still have over 70 lbs to go, so I don't want to abandon Zepbound altogether. It may take longer to get there, but that's fine if it means I can avoid side effects."

• SdS...
• Taken for 1 to 2 years
• February 13, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost a full year. I lost weight quickly: 90 pounds. I was at my goal in 6 months. I had to go back 2 doses to maintain and stop losing weight. The nausea has not stopped. It’s better than in the beginning, but I still get it every time for 1 or 2 days after a shot. The diarrhea is terrible. It has never stopped. I get it on day 2, and it is uncontrollable. It’s been almost a year, so I would think some of these side effects would have stopped, but they haven’t. I also get sulfur burps for a day or 2 after a shot. I’m at the point where I might have to stop taking it due to the side effects. I love the weight loss, and I sure don’t want to gain it back, though."

• SMP...
• Taken for 6 months to 1 year
• February 5, 2025

For Weight Loss (Obesity/Overweight) "I’ve lost 43 lbs in the last 9 months. I experienced some mild hair loss (but started this in menopause, so that contributed to hair loss as well), increased heart rate, although mine was low to start, some burping, and tiredness. The worst side effect for me is the diarrhea. I have it starting about 24-48 hrs after injection. It lasts on and off for about 3 days. Overall, these side effects have been mild and manageable. The weight loss has been life-changing!!"

• Ran...
• Taken for 1 to 6 months
• May 25, 2025

For Weight Loss (Obesity/Overweight) "I started on the 2.5 mg starting dose. After the second day, I was experiencing severe diarrhea, burping, nausea. These went away on Day 6. Very tolerable after then. I stayed on 2.5 for several months before going to the 5 mg dose, due to the intensity of my side effects. Started Day 1 of the 5 mg dose, and on the 3rd day after it I had tiredness, orthostatic hypotension (85/55 when standing up). At the 5th day, I am still having orthostatic hypotension - I maintained a water source. Spent 2.5 days without eating. I also vomited a couple of times during the 5 mg startup. Once this batch of side effects goes away, probably will be fine. I just think that a warning about the SEVERE side effects that make me functionally worthless should be discussed. I believe my side effects are a little more extreme than most, but folks should, at least, be informed."

• JWa...
• Taken for 1 to 6 months
• March 28, 2025

For Weight Loss (Obesity/Overweight) "Zepbound was effective within the first week. I experienced a significant decrease in hunger and decreased interest in food. I also found that I could not always finish a meal serving in one sitting. Initially, I had minor issues in bowel habits (constipation and diarrhea). Both symptoms are minor and managed with adequate hydration and fiber-rich foods. More disconcerting have been the “egg burps” caused by bacterial action on sulfur-rich foods in a slowed GI system. I have selected less sulfur-rich foods and make a concerted effort to drink more water during a day or two following the weekly injection. This side effect seems to have moderated, perhaps as I am into the second month of my current dosage and third month on Zepbound and/or temporarily minimizing sulfurous food intake in a short period following injection. I also track my food intake and assure I am eating an adequate level of protein. I have lost 15 pounds in 10 weeks. I am 77 and a woman."

• DrC...
• Taken for 1 to 6 months
• August 17, 2025

For Weight Loss (Obesity/Overweight) "I had no side effects at the 2.5 and 5.0 dosages, but severe bouts of diarrhea and belching occurred soon after the first injection of the 7.5 ml dosage. After consulting with my primary care provider, I kept taking the 7.5 dosage that resulted in nocturnal diarrhea. Therefore, I have decided not to continue with Zepbound. I have only had two injections of the 7.5 ml dosage. Prior to taking Zepbound for weight loss and obstructive sleep apnea, I had taken Wegovy and had no significant side effects other than constipation at the 0.025, 0.050, and 0.075 dosages, but when I tried the 1.0 dosage, I had diarrhea and severe abdominal pain, so I decreased the dosage to 0.05 and lost 36 lbs in 6 months. With Zepbound, I lost 14 more lbs until the severe nocturnal bout of diarrhea. So in total, I went from 246 lbs to 196 lbs, and my need for my CPAP machine was significantly reduced."

• Ano...
• Taken for 1 to 6 months
• August 15, 2025

For Weight Loss (Obesity/Overweight) "I was on Wegovy for a few months starting last year. I had GI issues going on and ended up getting off Wegovy in January of this year. I had gallbladder removal surgery in March. Issues went away. I consulted with my GI doctor to see if I could get back on Wegovy. He said I should be fine. Went to my PCP and asked about getting back on Wegovy. She recommended Zepbound as “side effects are less.” I’ve been on Zepbound for 3 months now. Lowest dose. After the second day of injection, I get the worst sulfur burps and diarrhea. Once I have a sulfur burp, the diarrhea is inevitable. It’s gotten to the point where it wakes me up in the middle of the night and I have to use the bathroom. This just started happening within the last month. It usually lasts about a day. Never had these issues with Wegovy. In fact, Wegovy worked much quicker with me as far as losing weight. Didn’t have these burps and diarrhea when I took it for months."

• 1 d...
• Taken for 1 to 6 months
• July 18, 2024

For Weight Loss (Obesity/Overweight) "I have had zero issues with the drug when I do right. If I overeat, I have diarrhea and sulfur burps for sure. When I start my day with protein and coffee, and drink lots of water, I have zero issues. But if I mess up like I did this week (ate breakfast, lunch, happy hour, snacked), I was up all night in a world of hurt, and I still haven't fully recovered. I haven't noticed a significant weight loss in 5 weeks (10 pounds), but it’s been steady. Just DO NOT OVEREAT and drink plenty of water."

• Pro...
• Taken for 6 months to 1 year
• February 25, 2025

For Weight Loss (Obesity/Overweight) "I’ve been on Zepbound since 8/1/24 (305 lbs, 5’6). So far, I lost 65 lbs, I’m 45 lbs away from my goal. My current dose is 10 mg. I experience side effects within 24 hours of injection administration, ranging from nausea, vomiting, belching, diarrhea, abdominal pain, fatigue, and dizziness. The side effects last about 24-36 hours. The medication definitely decreases my appetite and cravings. My doctor stopped my BP medication as I continue losing weight and my BP readings are good. My husband has noticed that I stopped snoring, lol. My plan is to reach my weight goal and stop the medication. I have changed my relationship with food. I look at food more as fuel for my body instead of indulging and overeating. I also introduced portion control and exercise, mostly walking and swimming. My insurance covers the medication."

• Aut...
• Taken for 6 months to 1 year
• March 3, 2025

For Weight Loss (Obesity/Overweight) "I am 45 years old and female. I have been on Zepbound for eight months. I started at 275 lbs and am now at 235 lbs. The day after I first took it, my stomach was so full it hurt, just from my normal portion sizes. Over time, the dosage has increased to 7.5. I am a little more tired than usual, but that's a small price to pay. The vast majority of side effects occur when I overeat. There's no way to know which of these I will have then: pain in my stomach, egg burps, loud flatulence, and/or diarrhea. I have been sick a lot more than usual, along with swollen lymph nodes and hoarseness, but there's no way to know if they're related or not."