Zepbound and Constipation: What Users Say

• Fra...
• Taken for 1 to 6 months
• February 8, 2025

For Weight Loss (Obesity/Overweight) "I have been on the lowest dosage of Zepbound for about 3-4 months. I’ve lost 22-25 pounds. No, I haven’t increased the time spent exercising. But I am no longer hungry and stuffing junk food into my mouth. My tongue hasn’t forgotten it loves Snickers, but I am able to grab apples and be content. My nephrologist put me on it as I do have kidney disease, I was in the obese range, and I was prediabetic. It’s expensive ($400 per month), but I feel better about myself, and so it’s worth it to me. I was the fat kid in my family and have never been a thin and beautiful person. But Zepbound has given me higher self-esteem because it’s doing what it’s supposed to do… help me to shed weight in a healthy way. I do sometimes experience constipation, then a giant diarrhea round, but I feel good most of the time. I have no other side effects and have been pleased with the assistance Zepbound has given me. Thank you, Lilly Pharma!"

• JWa...
• Taken for 1 to 6 months
• March 28, 2025

For Weight Loss (Obesity/Overweight) "Zepbound was effective within the first week. I experienced a significant decrease in hunger and decreased interest in food. I also found that I could not always finish a meal serving in one sitting. Initially, I had minor issues in bowel habits (constipation and diarrhea). Both symptoms are minor and managed with adequate hydration and fiber-rich foods. More disconcerting have been the “egg burps” caused by bacterial action on sulfur-rich foods in a slowed GI system. I have selected less sulfur-rich foods and make a concerted effort to drink more water during a day or two following the weekly injection. This side effect seems to have moderated, perhaps as I am into the second month of my current dosage and third month on Zepbound and/or temporarily minimizing sulfurous food intake in a short period following injection. I also track my food intake and assure I am eating an adequate level of protein. I have lost 15 pounds in 10 weeks. I am 77 and a woman."

• ECT...
• Taken for 6 months to 1 year
• April 11, 2025

For Weight Loss (Obesity/Overweight) "Effortlessly went from 250 lbs to 198 lbs in 9 months, with very minimal side effects! It took me this long to go through the gradual dosage increases. When I missed a few weeks here and there, I regained weight. I’ve been extra committed to the regularity of doses after that! My only side effects have been: some mild constipation (take mg citrate to fight that), very mild diarrhea, heartburn that increased as the dosage mg increased, although eating TUMS like candy took care of it (but expensive because I insist on having the TUMS that taste good to me), and injection site reactions (similar to a mosquito bite ≈ 3 days, managed with OTC cortisol cream and/or OTC roll-on 4% lidocaine). I used to have no off switch; was always hungry! Now, my mom (Wegovy) and I look at each other in amazement and ask, “Is this what it feels like to be normal?” She’s been up to 300 lbs, had bariatric surgery, we’ve both done keto, nothing lasted. She’s now 160!"

• Anonymous
• Taken for 6 months to 1 year
• March 4, 2025

For Weight Loss (Obesity/Overweight) "It was rough in the beginning, with diarrhea, then constipation and heavy belching. The diarrhea ended after about a month, but constipation has continued. In addition to those symptoms, I experienced an undercurrent of nausea for several months, with it being more pronounced just after eating. After about eight months, the nausea abated for the most part. I started on the 2.5 and moved up in dosage every 2 months or so. I am entering month 10 and am on the 12.5 dosage. For the first 6-7 months, I lost approximately 1.5 lbs/wk, and over the last 2-3 months that has slowed down a little. I have lost a total of 50 lbs. The other side effect I've experienced is I sometimes have low blood sugar in the mornings, so I will have juice or something to help take care of it. It is easy to use, and despite the rough start, I am pleased with the results."

• Mk6...
• Taken for 1 to 6 months
• March 10, 2025

For Weight Loss (Obesity/Overweight) "I started in January 2025 with the 2.5 dose. For the first two weeks, I experienced nausea and diarrhea off and on. For the last two weeks, I was fine. I am on my second week of 5 mg. The first week, I was so sick - I take the shot late Friday afternoon - I was in bed most of the day on Saturday with nausea and fatigue. I did vomit once. Sunday was the same. The rest of the week, I felt fine. Second shot last Friday - I was okay on Saturday - able to function but very nauseous. Woke up on Sunday and spent most of the day in bed due to nausea and fatigue. The anti-nausea medicine helps but not so much for me. Today I am functioning with some nausea. The benefits of this drug are obvious. I don't eat as much as I did before the medicine. I've lost 16 lbs so far. The nausea bothers me. I should be able to function and not get sick every weekend after a shot. I no longer have diarrhea - I am constipated instead. When I take Miralax, I cannot think about it or I get sick."