Nucynta and Depression: What Users Say

• bam...
• August 4, 2010

For Pain "After chronic pain for 5 years (bursitis and fibromyalgia), I think I've found a medicine perfect for me. I take 50 mg three times a day; it has helped so much with the fibromyalgia fatigue/fog. I have more energy, feel less depressed, and actually wake up without horrible pain. In the past I have been on Oxycontin, MS-Contin, Hydrocodone, Fentanyl patches, and Dilaudid. Nucynta is helping more than all of the above and it's much different than a typical narcotic. I am pleased!"

• Lau...
• February 13, 2020

For Pain "I've never had more side effects with any other medication. I ended up in the ER, I'll get into that more later. Blurry vision, can't read off my phone. Can't focus my eyes, they feel strained. It causes this 'psychedelic effect' where things look like they're moving with slight colors. Chest pain. Went to the ER. They gave medication to slow my heart rate, which was 150 bpm. Heart pounding, tightness in chest, fast heart rate, low blood pressure. Unable to concentrate/poor memory. Forgetting mid-sentence. Dizzy, the room is spinning. Uncoordinated. Depressed breathing. Hallucinations. I thought I saw a red bug on me, but it was just my birthmark, I was hallucinating! I've never hallucinated before. Restlessness. The skin on my hands and feet turned blue. Anxiety/depression. I have slight anxiety, but not like this, it made me depressed. Urinary pain (from the coating on these pills made to prevent people from misusing them). Heaviness in limbs. Trouble swallowing. Severe constipation. Indigestion. Low energy."

• Ohi...
• Taken for less than 1 month
• May 9, 2015

For Pain "I have CRPS in my left foot. I have a spinal cord stimulator (paddle leads). I have been on pain meds since 7/2013 after an accident. Meds tried through prescription from pain mgmt. Norco, Percocet, OxyContin, Morphine ER, Butrans and more. Nucynta was prescribed April 2015. I took it for 1 week. I am a very positive person who is always seeing the good in any situation. Nucynta made me depressed, moody, not wanting to get out of bed, quiet and overall someone I do not want to be. It did aid in my pain control, but I cannot be that person it made me. After being off of it for 2 days, I am back to being my positive self. Would I recommend it? I don't think so."

• Bor...
• March 22, 2015

For Pain "Awesome drug with no narcotic hangover. With radiation damage to all the organs that I still have, the pain never goes away. Nucynta (600 mg/day) has allowed me to have a tolerable life and work much better. Best medicine since Vioxx (which was removed from the market). My pain level is down to a 6 or 7 now. Very pleased. Much better than traditional opioids that cause highness, mental, and go problems. Clear-headed on this med."

• kad...
• Taken for less than 1 month
• March 24, 2016

For Pain "I was prescribed this medication because I'm allergic to some of the more common painkillers. I took it a total of 2 weeks, daily as prescribed. I had horrible hallucinations, became severely depressed, had insomnia, and I felt like every ounce of joy was sucked out of my body. I had the strangest experiences with this medication. I felt like I left my body. Once, I saw myself jumping off the balcony. I was clearly hallucinating. It was the worst experience from a medication I've ever had. I was extremely distraught but had no idea why. My husband freaked out and rushed me to the doctor. I was told that it was side effects of the medication. I had to be weaned off of it by a doctor. Even under the doctor's care, I had horrible withdrawal symptoms."

• sen...
• Taken for less than 1 month
• December 11, 2016

For Pain "I have severe, constant pain following 4 serious car accidents (none my fault) over 14 years. I was taking OxyContin 10 mg x5 per day, and my Dr. recommended I try Nucynta. I don't know why. It was more expensive and not available in a generic form. After three days, I felt it was less effective in controlling my pain. On the fourth day, I woke up and felt I had nothing to live for and my life had no meaning. I have depression and PTSD caused by the accidents, but these conditions are well controlled by other medications. I normally don't have these thoughts. I believed this was a side effect of the Nucynta, so I immediately stopped taking it, and those thoughts went away right after."

• Bet...
• Taken for less than 1 month
• September 3, 2012

For Pain "I was having pretty severe post-surgical pain. OxyContin gave me a pounding headache and caused depression and insomnia. Tramadol did not help. I started taking Nucynta 50 mg yesterday. I must say, on a scale of 1 to 10, my pain is now a negative 10! When it wears off, it's pretty sharp and uncomfortable. I take 1 50 mg tab every 4-6 hours. The doctor said I can take 2 pills, but I haven't needed to. I recommend this for anyone who has issues with the usual pain medicines. I have also been drinking prune juice because it does have a constipation effect."

• axi...
• Taken for less than 1 month
• March 8, 2013

For Pain "The first 4 days were great, no pain and no lethargy. Day 5 began with stomach upset and hot flashes. Day 6 brought anxiety ending in severe depression and a psychotic break. All resolved after cessation in 24 hours."

• ger...
• August 4, 2011

For Pain "I am suffering very severe back pain due to a ruptured disk L4-5. I have been on Nucynta for two weeks now. I started with the blue pill 250 mg twice a day (every 12 hours). The pain subsided with the first dose within 45 minutes. All I felt was a warm, fuzzy sensation throughout my body. I was somewhat tired, but not too bad. I felt detached for some time, like I was not in the room. I had some difficulty remembering what I was going to do. I decided to do something, and a few seconds later I could not remember. This happens quite often after I take my dose. All in all, I am very happy with this medication for pain. It really does help."

• Sti...
• June 5, 2011

For Pain "Was prescribed Nucynta for pain associated with sciatica and herniated disk in L5/S1. Although it did relieve the pain, the side effects I've experienced are just not worth it. Horrible headache, itching, sweating, constipation, and depression."

• kco...
• May 22, 2011

For Pain "I have been taking Nucynta for about three months and take only 2 x 50 mg tablets per day. At first, it worked very well with no side effects, except I felt euphoric and a bit sleepy. Therefore, I only took Nucynta at night. But now, in the mornings, I notice that I wake up very depressed and unable to handle the day. I do find that 1 plus hours of morning exercise helps me get over these feelings. I believe I need to wean myself off of this medicine."