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Semaglutide and Tiredness: What Users Say (Page 3)

Brand names: Ozempic, Rybelsus, Wegovy

Reviews for Semaglutide

Commonly mentioned side effects
  • Car...
  • Taken for 1 to 6 months
  • April 24, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I am on week 4 of Wegovy, the first 2 doses were 0.25 mg. The last 2 were 0.5 mg. I've had stomach pains and nausea to the point I'm in tears, it aches so much. My weight is going from 221 lbs to 215 lbs, I'm 5'9". I hardly eat for fear of worsening stomach issues. While my pharmacist says the side effects should go away by now, they haven't. I also have no energy, want to sleep, and have a hard time getting my blood sugar above 98, that's after a healthy meal with protein and a vegetable. Not sure this is worth it."

4 / 10
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  • Ext...
  • Taken for 1 to 6 months
  • January 18, 2023

For Weight Loss (Obesity/Overweight) "I took my first injection on Dec 17, 2022, so I'm 4 1/2 weeks in (1 month). I'm on the 2.4 mg injection. Started at 30 units. Lost 9 lbs the first week. Gained weight the following weekend over Christmas, and also a bit over New Year's weekend. As of this morning, I'm down from 238.6 lbs to 218.4 lbs...that's 20 pounds in a month, including the weight I had to lose twice from gaining over the holiday weekends! I take my injections on Saturday. Side effects: nausea on Sunday, very, very light. Enough to notice, but not uncomfortable. Tired on Monday mornings. Take B12 and fine in a couple of hours. A little bit more tired on Tuesday mornings. Again, B12 and fine. Feel good on Wednesdays. Thursday, I have an abundance of energy. Friday afternoons, I can feel the rumblings of hunger, but don't really feel like eating. Saturday, it's time for the injection again, so the rumbling stops. I haven't experienced any other side effects."

10 / 10
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  • Daw...
  • Taken for less than 1 month
  • May 24, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "Just started this new medication, and I’m on my second injection of the .25 mg. The side effects I have had are slight abdominal pain, acid reflux, nausea, and tiredness. I am 5’8 and was 244.5 lbs. To date, I am now 239 lbs - I’ve lost 6 lbs since 5-21-23. I weigh in every Sunday to stay on track of my weight and what it is. The side effects are mild, and I am going to stick with it because, like so many others, I’m tired of being TIRED… the weight has to go, and I encourage you to try this."

10 / 10
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Frequently asked questions

  • Nap...
  • Taken for less than 1 month
  • November 30, 2024

For Weight Loss (Obesity/Overweight) "No side effects until the end of week 2, spontaneous vomiting after lunch today. Nausea & immediately vomited until stomach empty. Feeling more tired than usual. Felt really cold last evening—used heating pad for warmth."

6 / 10
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  • Ted...
  • Taken for 1 to 6 months
  • February 12, 2025

For Weight Loss (Obesity/Overweight) "This drug has definitely helped with decreasing my appetite and decreasing sugar cravings. I've been on semaglutide for 6 weeks and have lost 13 lbs so far. As far as side effects go, I've experienced some tiredness, nausea, and some stomach discomfort. Nothing debilitating. I'm going through a weight loss center. I go once a week for counseling and injections. I started out at 0.25 injection the first 30 days and am now up to 0.5 injections once a week."

10 / 10
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  • lol...
  • Taken for 1 to 6 months
  • September 26, 2024

For Weight Loss (Obesity/Overweight) "So far, I've been on it for one month. I lost 7 lbs, my goal is 10, so I've decided to stay on it one more month. I do get nauseated and exhausted quicker than usual, but if I sit for a minute, it usually passes. It definitely helped my calorie deficit. I had to tell myself to eat because I wasn't hungry most of the day, but very thirsty, so I drank about 1/2 to one gallon of water a day. It has diminished my cravings for sweets as well, I don't even want it. Good luck to everyone, I'm sure, as with anything, results are different for everyone. Be safe and eat fresh."

9 / 10
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  • BHW...
  • Taken for less than 1 month
  • September 23, 2024

For Weight Loss (Obesity/Overweight) "I began taking the 0.25 dose 4 weeks ago (I will take my first dose of 0.5 this upcoming week). I was VERY hesitant to begin this journey due to the reviews I have read regarding side effects, but I am fortunate enough to not have experienced many. I can say I was a bit lethargic the first few days, and I do experience mild nausea if I do not eat. Prior to taking this drug, I was constantly hungry, and the food noise I experienced was constant - it regularly affected my daily functioning. However, about 48 hours after taking the first dose, I began to notice a difference. I legitimately have not experienced the sensation of hunger in 4 weeks, which is a GAME changer for me. I have not made any drastic changes to my diet or exercise, as I was already eating quite healthy and working out 3-6 days a week. I have lost 16 lbs - will update on my journey in a month or two."

10 / 10
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More FAQ

  • Mon...
  • Taken for 1 to 6 months
  • July 27, 2025

Semaglutide for Type 2 Diabetes "Not impressed. Have been on it for 6 weeks, has not lowered my blood sugar significantly. Gone down from 10.2 to 8.0, sometimes 7.7. Side effects outweigh the benefit of lowering my blood sugar. Side effects are bad, and I don’t want to go on with taking Ozempic. I used to have regular bowel movements, now I can only go every 4 to 5 days; I get bad tummy pain and in the stomach region too. Heartburn is bad too. Runny nose drives me crazy; it’s like a dripping tap. Nausea is a problem too. Not to mention bad smelling farts. It’s just too much to cope with. I would not want to go on with this treatment. Dizziness and tiredness are part of my everyday experience. My dosage is only 0.25 mg."

2 / 10
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  • Sue...
  • Taken for less than 1 month
  • June 1, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I need help to decide if Ozempic is good for me. The side effects scare me: nausea, vomiting, constipation, and exhaustion. Yikes! I really need the weight loss, though. I really want to try it. I'm curious if insurance will cover it."

7 / 10
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  • Lis...
  • Taken for 1 to 6 months
  • February 7, 2025

For Weight Loss (Obesity/Overweight) "Works really well to help lose weight, but the side effects are awful. I had them all: dizziness, nausea, heartburn, constipation, tiredness, joint pain."

7 / 10
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  • bcs...
  • Taken for 1 to 6 months
  • April 17, 2025

Semaglutide for Type 2 Diabetes "I tolerated the 3 mg course. I'm 12 days into the 7 mg pills, and I've had nausea, dizziness upon standing, and tired for the last four days. I'm getting ready to email my doctor for his advice."

7 / 10
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  • Ano...
  • Taken for less than 1 month
  • April 26, 2025

Semaglutide "Incredible that one's appetite just vanishes. Sadly, the side effects are quite dramatic. Nausea, burping, tiredness. Not such a good combination."

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.