Semaglutide and Tiredness: What Users Say (Page 2)

• blh...
• Taken for less than 1 month
• May 31, 2024

Semaglutide for Weight Loss (Obesity/Overweight) "First dose 0.25mg, had slight stomach pain/discomfort. Later that same night, my appetite disappeared. Just seeing a fast-food commercial on TV made me feel nauseous. I thought if that's the worst of the side effects that affect me, then I'll be very happy with that. By the next day, stomach pain and nausea increased. By 4:00 am, BAM! Diarrhea, severe stomach pain, projectile vomiting, headache, chest pain, severe itching mainly on the palms of my hands and arms. I truly thought 'this must be what it feels like to be poisoned!' I was scared. It is now the next day and I feel fine. A little tired from lack of sleep from feeling so sick. I think I will do my second dose next week...but I'm quite nervous of a repeat of feeling like I was dying from the stomach pains and vomiting. Will I continue with this drug?...jury is still out! On the positive side, I've already lost 5 pounds; but of course, I can't & don't want to eat, too much nausea and vomiting."

• Sic...
• Taken for 1 to 6 months
• August 13, 2019

Semaglutide "I’ve been on Ozempic since May to help with weight loss. Started with 0.25 and now am up to 1 mg. The nausea has been fearless. The constipation is unreal. I’ve ended up with major hemorrhoids. I’m always tired. I have lost 14 lbs, but these side effects are ruining my life. This is not worth it."

• AK4...
• Taken for 1 to 6 months
• April 11, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I started Ozempic for weight loss. I paid cash since I wasn't approved by insurance. I was about 15-20 pounds overweight and pre-diabetic with a family history of type 2 diabetes. No matter what I did, nothing made me lose weight. The first month at .25 mg was a dream come true. I had no appetite and felt very few side effects. I lost 10-12 pounds in the first month. The 5th shot was .5 mg. I became so ill. It started with huge belches and nausea. That night I vomited and was so lethargic and nauseous that I didn't get out of bed for 3 days. I had weird sores on my tongue. The next day I vomited again. I had to get Zofran for the nausea, which helped a bit. Almost a week later, I am due for this week's shot, and I have decided not to continue. I still have the belches from hell, weakness, and lethargy, but I am at least able to function and work. Climbing the stairs feels like Mt. Everest. I hope I feel normal again soon."

• Eda...
• Taken for 1 to 6 months
• February 6, 2020

Semaglutide for Type 2 Diabetes "So I have been on Ozempic for 5 weeks. I am tired a lot. Not sure if this is the drug or my poor sleep, but now that I see others are tired a lot, it makes me wonder. I have nasty burps a lot. I started on a dose of 0.25 for 4 weeks. I had a lot of low-level nausea, but not too bad except for one day. Then last Sunday, I took the higher dose of 0.5, and I was okay on Sunday and Monday, but Tuesday the nausea was horrible, and I had explosive diarrhea all day to the point I had to take Imodium, and I got my doctor's office to prescribe an anti-nausea med, Zofran, which helped a little. The next day, less nausea, and today is Thursday of that week, and I still have the burps and more BMs than I would like, as well as a lot of gas. I know I have lost weight just by how my clothes fit. I have very little appetite. Not sure if the pluses outweigh the minuses yet. I am probably going to try one more week and see how I feel. It has had a modest impact on blood sugars. I have been using less insulin."

• Ale...
• Taken for 1 to 6 months
• June 2, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "I lost 15 lbs in 2 months, but during the end of my treatment, I discontinued use due to worsening side effects such as: chest tightness, weakness, lethargy, extreme nausea, diarrhea, shortness of breath. I also experienced cotton mouth; however, I am unsure if this was due to this medication, as I had a wisdom tooth removal during this time. My treatment started at 0.25 mg for 4 weeks and then increased to 0.5 mg for weeks 5-8, then increased to 1.0 mg at week 9, which is when the side effects became alarming, and I chose not to increase the dose. At week 10, I did increase to 1.0 mg and decided to stop after, as I chose to listen to my body and not push it. The ease of use was fine as I don't mind needles too much; the sensation was slightly uncomfortable but not painful."

• wis...
• April 15, 2021

Semaglutide for Type 2 Diabetes "I've been on Ozempic for 7 weeks now: 4 weeks at 2.5 and half the usual insulin dose, followed by 3 weeks at 5.0 and no insulin, as instructed by my endocrinologist. I experienced leg cramps, stomach cramps, lethargy, and light-headedness among other symptoms in the first 4 weeks. My fasting sugar results increased. During my 3 weeks on the 5.0 dose, I have suffered feelings of nausea, regular bouts of light-headedness, and my fasting sugar levels are now up to the 14-17 range. My energy levels are decreasing. I am taking myself off this medication over the next 3 weeks. An interesting experiment to undergo but not worthwhile continuing as there are no benefits (except weight loss - and I can't afford to lose too much more weight) but light-headedness, lethargy, feeling like vomiting regularly, increased cramps, and, worst of all, my blood sugar levels going through the ceiling. Concentration levels are also a concern."

• Car...
• Taken for less than 1 month
• July 25, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I am on my second week. First week (day after shot) I got severe nausea and dry heaving. I was so exhausted and zero energy. My depression got way worse. Second week the same. I don’t think I will continue, but I signed a contract, and I was told I can cancel at any time, but it looks like this is going to be a problem. This has been a wake-up call, and the nausea has taught me a lesson to never eat bad foods again and really focus on portion control. The side effects aren’t worth any weight loss in my opinion!"

• Gro...
• Taken for 1 to 6 months
• October 26, 2019

Semaglutide for Type 2 Diabetes "Have been on semaglutide for 8 weeks and am presently on a 1 mg dose. First, the positives. I have lost 16 pounds, my intake of Novorapid has decreased significantly, and my blood glucose has dropped from 7.9 to 6.8. Negatives: mild constipation, bloated feeling, slight nausea, reflux acid, lethargy, and wind (burps and farts). I feel the positives outweigh the negatives at the present time, but only time will tell."

• Car...
• Taken for 1 to 6 months
• June 4, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "In February of '23, I learned that I had a hiatal hernia where 2/3rds of my stomach was above my diaphragm. The doctor said she could operate, but it wouldn't stay fixed because of my body mass. So my primary care PA suggested Wegovy. I agreed to try it. The first 3-4 days of my first week were rather rough. I had horrible gas, diarrhea, and nausea. I could eat berries and yogurt, but not much else. Over the first 2 months, I lost 12 pounds. Then I plateaued. There also was a mix-up with getting my next 4 doses on time, so I went a couple of weeks with no doses. Most recently, we upped my dose, and now at 1.7 mg, I don't have many stomach problems, but I feel tired all the time. I get up and do a few things, and then I take a nap. And repeat. I had one time when I started to feel dizzy and faint because my blood sugar was low, but a sweet drink and a burrito helped with that. I am still slowly losing weight, which makes me happy! I've lost a total of 18 pounds in about 4 months."

• Hoo...
• May 17, 2018

Semaglutide for Type 2 Diabetes "Initially began Ozempic 0.25mg for 4 weeks. Side effects were tiredness, constipation. My fasting blood sugar numbers were lower in the morning. When I began the 0.50mg dose at 5 weeks, I had nausea, dizziness, and lethargy the day following the first dose. The second day following that dose, I felt about 70% better. With the second dose of 0.50mg, side effects were less severe, some minor nausea, headaches, and the tiredness continued. I hope that these side effects disappear. I plan to take this medication until I get my 3-month labs, and I expect that my A1c will be down significantly. It was at 5.9 in July of 2017. Due to the stress of caring for a dying relative from September through December, it jumped to 9.3. At my next appointment, my doctor suggested I try Ozempic in combination with Metformin 500mg twice a day. I received a 3-month discount card and have not yet checked with my health insurance provider to see if it will be covered. I am an active 61-year-old female, but type 2 diabetes does run in my mother’s family."

• Hoo...
• May 17, 2018

Semaglutide for Type 2 Diabetes "Initially began Ozempic 0.25mg for 4 weeks. Side effects were tiredness, constipation. My fasting blood sugar numbers were lower in the morning. When I began the 0.50mg dose at 5 weeks, I had nausea, dizziness, and lethargy the day following the first dose. The second day following that dose, I felt about 70% better. With the second dose of 0.50mg, side effects were less severe, some minor nausea, headaches, and the tiredness continued. I hope that these side effects disappear. I plan to take this medication until I get my 3-month labs, and I expect that my A1c will be down significantly. It was at 5.9 in July of 2017. Due to the stress of caring for a dying relative from September through December, it jumped to 9.3. At my next appointment, my doctor suggested I try Ozempic in combination with Metformin 500mg twice a day. I received a 3-month discount card and have not yet checked with my health insurance provider to see if it will be covered. I am an active 61-year-old female, but type 2 diabetes does run in my mother’s family."

• Cap...
• Taken for 1 to 6 months
• May 12, 2021

Semaglutide for Type 2 Diabetes "I took Ozempic last October, but I had to come off it - I was so ill. I'm type 2 diabetic and Hashimoto's thyroiditis autoimmune disease. I'm 57 years old and post-menopause. The doctor decided I should try again, I started 5 weeks ago and had my 5th injection. I have been sick since I restarted. I have nausea, vomiting, diarrhea, brain fog, anxiety, burning in my stomach, headaches, and I'm so tired and weak. I tried to stick with it, I'm on the 3rd day since my 5th injection. I am so ill, I still have all the above symptoms, but worse. My kidneys are sore and my lungs. I have pain in my stomach and back. I feel like my body is poisoned, and I have to wait for 5 weeks for it to clear out of my system. I will never take this again."

• Daz...
• Taken for 6 months to 1 year
• December 29, 2022

For Weight Loss (Obesity/Overweight) "Started Semaglutide in April. I felt sick for pretty much 2 months and almost gave up several times, but since the weight was coming off and my husband was doing it with me, I decided to keep going and took Zofran for nausea. My side effects: exhaustion, diarrhea, nausea, gas cramps, and light-headedness. Sometimes I still feel those things, but my body has adjusted mostly to it. In the beginning, I didn't feel like eating, and nothing sounded good. Now, I am hungry but can control my snacking. I lost weight quickly - 35 pounds. I had to keep buying new clothes. I do not want to lose any more weight since I reached my goal weight. Now, I take 30 units weekly to maintain the results. My cholesterol is the best it's been in years! I do work out 3 days a week, but I always have. I just couldn't lose any weight and ate too many snacks at night. This prevents snacking. Be careful not to lose weight too fast. I now have to deal with sagging skin. My husband and I still feel it's worth it though."

• yir...
• Taken for less than 1 month
• May 2, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I started Wegovy .25 mg on March 5th. On day 1, I felt a little nausea and a little tired. Felt fine the rest of the week, appetite suppressed after a day or so. Continued to follow a healthy diet, exercised at least 5 days a week, and meal portions became smaller. I did not experience any other side effects aside from a little heartburn at night after the 2nd dose. By the 3rd dose, I started feeling somewhat constipated and noticed my watch was notifying me more frequently than usual that my heart rate was over 100 throughout the day and night. I take blood pressure medication, so I decided to call my doctor. She does want me to get blood work done and will be checking my thyroid. Also recommended I stop taking the med. I am a bit worried as I already feel the cravings are coming back. After I complete blood work, I will provide additional feedback regarding recommendations from my PCP. I have lost about 14 lbs., so it does work. I would give it a shot, everyone reacts differently."

• Vel...
• Taken for 1 to 6 months
• February 23, 2023

For Weight Loss (Obesity/Overweight) "Started in December 2022 and on a compounded version, and to date have lost maybe 5 lbs. It's hard to tell as I am constantly bloated, constipated, and have gas pains, terrible heartburn, nausea, and feel really tired. I have experienced these side effects from the first 0.05 dose up to the 2.4 that I am on now. I am weaning myself off of it as it is not beneficial to me."

• hal...
• Taken for less than 1 month
• June 4, 2023

Semaglutide for Type 2 Diabetes "The major side effects are all I got with this med, which includes upset stomach, heartburn, burping, gas, bloating, nausea, vomiting, stomach pain, loss of appetite, stomach flu symptoms, headache, dizziness, and tiredness."

• OCo...
• Taken for 1 to 6 months
• May 29, 2023

Semaglutide for Type 2 Diabetes "I started Ozempic at the end of March 2023 for overall better A1C control, weight loss, and reduction in cardiovascular risk. Started at 0.25 mg for the first week and increased to 0.5 mg since. For the first month, I had strong nausea, lightheadedness, and significant constipation with abdominal discomfort. I also felt very tired all day, which I found was due to not eating enough carbs daily, as Ozempic tends to significantly reduce the appetite. I stuck with it, and after one month at 0.5 mg, the only remaining issue is constipation, which I try to manage through over-the-counter laxatives and prescription medication once a day. Over two months, I lost 25 pounds (235 lbs down to 210 lbs)! My daily fasting blood sugar results are down 20-25 points from before starting Ozempic (A1C to be tested in one more month) and managing my energy level by ensuring enough carb and protein intake. So far, so good!"

• P R...
• Taken for 1 to 6 months
• May 23, 2023

Semaglutide for Type 2 Diabetes "First 4 weeks I injected 0.25 mg units once a week. Second 2 weeks I injected 0.50 mg units once a week. I have lost 7 lbs. I am injecting 40% less insulin. My A1c has reduced from 7.0 to 6.6. This all sounds great, but the adverse side effects have me on the verge of stopping my use of Ozempic permanently. I have experienced confusion, dizziness, nausea, unusual tiredness, weakness, passing gas, and feeling the need to vomit, these are the most prevalent side effects. The side effects are interfering with my lifestyle too much."

• SuT...
• Taken for less than 1 month
• August 4, 2021

Semaglutide for Type 2 Diabetes "I have been on Rybelsus for 11 days now. The first few days were horrible. I had diarrhea and stomach pains, even threw up twice. I am still having side effects on day 11 but not as bad. I’m taking Zofran for the nausea. I have already lost 8 lbs, which I’m sure is not healthy, but I don’t have an appetite on this medication. Before this medication, I would eat all the time, it seemed like I never was full. My sugar levels are as low as they’ve ever been. I am tired and have lower energy. I'm hoping after another week on it the side effects will subside. I have been struggling with weight loss my whole adult life and can never break through the plateau phase. I think this medication will help if I can withstand the side effects."

• Sha...
• Taken for less than 1 month
• May 26, 2018

Semaglutide for Type 2 Diabetes "My first week, I felt tired and had no energy. Mild, intermittent nausea. Guess that's the appetite suppressant part. After the first 3 days, I started getting quite a bit of stomach discomfort and diarrhea. Anything I ate or drank went right through me, as well as gas. Also, an unusual amount of belching. Hope this goes away soon and does not happen after every dose. I teach 4-year-olds, and it greatly affected my ability to do my job. My BS numbers are not much different."

• Rav...
• Taken for 1 to 6 months
• June 2, 2022

Semaglutide for Type 2 Diabetes "Bad stomach pains and nausea/diarrhea the day of the shot and for a day or two after, and extreme tiredness. On week 8 and .50 dose. Hardly can eat solid foods, full within 4 or 5 bites, but not losing weight as promised- I don't like it so far, just misery!"

• Kat...
• Taken for 2 to 5 years
• October 10, 2024

Semaglutide for Type 2 Diabetes "I have been on Ozempic for Type 2 diabetes. Was overweight as well, I am 4'11 and had ballooned to over 170 pounds. I was taking medicine for blood pressure, anxiety, depression, you know, all the things. I started in March 2022. My A1c was 7.9. Today I am down to 105 (hold up, that is normal for my height). No more high pressure. Beginning, I wasn't sure I would get past the nausea, but I fought through it, and yes, it does go away. I have been on stool softeners for a while, so I have never had any issues going to the restroom. My A1c is 5.4 now. I don't feel good, though. I can't put my finger on it, but I am severely exhausted and fatigued. I will not trash this medicine because I think it works as it should and has been amazing for diabetics. I just wish I didn't feel like poo all the time. The side effects do subside over time. My doctor and I have found the perfect dosing and schedule for me to keep my blood sugar under control."

• Bet...
• Taken for 1 to 6 months
• April 25, 2023

Semaglutide for Type 2 Diabetes "Ozempic is definitely helpful in lowering my A1C, and for that, I am very grateful. I have struggled with type 2 diabetes for over thirty years. However, I am enduring dizziness, mild nausea, tiredness, and a general feeling of being unwell. In the days of my elevated sugar count, I actually felt well, without any of these symptoms. I am experimenting with the dosage of Ozempic and intend to cut back to the 0.5 mg dose next week. I just can't handle the 1 mg."

• Rih...
• Taken for 1 to 6 months
• May 20, 2024

Semaglutide for Type 2 Diabetes "I have type 2 diabetes and I am obese. I started this medication in November 2023. I stopped using it for three months due to a shortage in the market in my country. I used 0.25mg for the first month, 0.5mg for the next three months, and 1mg for two months. The last dose of 1mg was taken on May 17, 2024. In November, I weighed 91kg, and I have reached 75kg or perhaps even less now. For my health, I feel significantly better while working or going upstairs. Regarding side effects, I experienced tiredness, vomiting, headaches, nausea, constipation, and stomach pain."

• Anonymous
• Taken for 1 to 6 months
• September 12, 2023

For Weight Loss (Obesity/Overweight) "I am 5'6" and weighed 182 on May 19, 2023, when I started semaglutide at the local weight loss center. My weight is down 22 lbs, and I am happy about the way I'm looking. I should mention I am a 68-year-old active senior and work out M-F with moderately high intensity. My dose is 1.2 now to keep the cravings away. My goal weight is 150 lbs, and I'm at 162 lbs now. I do not drink, but when I've had 1 or 2 (max) alcoholic drinks, I am in misery the next day with a very bad hangover feeling. Also, if I make fruit cobblers or anything sweet and I eat it, I feel lousy the next day. I have lived off of Pepcid and bicarbonate water this entire treatment time. Exercise is difficult without the Pepcid, as I feel reflux during high jumps or deep bends. My mood is grouchy sometimes because of the tiredness and intermittent waves of nausea that are random. Still, it's the best way I've ever lost weight because it works."