Semaglutide and Fatigue: What Users Say (Page 3)

• Anonymous
• Taken for 1 to 6 months
• June 30, 2024

Semaglutide for Type 2 Diabetes "After 4-6 weeks, I still suffer various levels of intensities of nausea, but short-lived diarrhea, plenty of burping, and fatigue that is often overwhelming. Some days, no problems. I manage the symptoms by enduring until they ease up, or I may choose to seek fast relief using what's available. Its benefits are now close to 'tight control' and significant weight loss (overcoming the stagnant plateau of a period of weight loss)."

• Pat...
• Taken for 1 to 6 months
• August 29, 2022

Semaglutide for Type 2 Diabetes "I have been taking this drug for about 8 weeks, starting out with the 0.25 dose and now on the 0.5 dose. I have felt miserable the whole time, with nausea similar to pregnancy and with a revulsion to most food and smells of food cooking. Definitely low energy. I have lost weight, and I haven’t had my A1C checked since I started. I will see my doctor in a couple of weeks and will be telling her that I can’t continue to live this way. I’m 75 years young and don’t want to live the rest of my years feeling bad! Unusual, hiccup-type burps, coming out of nowhere and no appetite. Convenient once-a-week administration."

• Mem...
• Taken for less than 1 month
• September 3, 2021

Semaglutide for Type 2 Diabetes "I have Type 2 diabetes that I’ve kept under control by taking Metformin, Jardiance, and insulin. I saw a new endocrinologist 2 weeks ago who suggested I try Ozempic, with the hope of eliminating the insulin. She prescribed taking .25 mg initially for 4 weeks and then bumping up to .50, also reducing my insulin to 15 units and hopefully eliminating it later. She did say it could cause some stomach issues, but mainly said it could make you not want to eat much. I think in hindsight she downplayed the side effects. I took my first dose a week ago. The first 3 days were fine. The 4th day I started having foul-tasting belches and then got such severe stomach/gas cramping I almost went to the ER. I have a high pain tolerance, so for me to be in that much pain says a lot. I was able to finally get relief by drinking baking soda water, but then had extreme diarrhea, nausea, body aches, and fatigue. I missed 2 days of work. I called the doctor, and she said my symptoms were severe and to stop taking it. Horrible experience!"

• S-L...
• Taken for 6 months to 1 year
• February 2, 2023

Semaglutide for Type 2 Diabetes "Major nausea ebbs and flows. Extremely bad fatigue off and on. More along the lines of exhaustion. No weight loss. I’m on a pretty high dose, 1.5, and am only about 15 lbs overweight. Diabetes type 2 most of my life, so this is a great drug. Hopefully, the next generation of these drugs will have fewer side effects for some of us. The nausea and fatigue are pretty overwhelming some days. A1c has improved, so I will stay on until something better comes along."

• Tko...
• Taken for 1 to 6 months
• May 23, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I started approx. 3/29 and will begin my third step up to 1 mg this week. I have lost 23 lbs in 8 weeks. Very happy about that. My appetite is reduced. I can sometimes skip dinner because, after a light lunch and breakfast, I am not hungry. I have experienced fatigue, nausea, and constipation. However, if I eat something like an apple with peanut butter, that helps with the constipation. So far, these side effects are not bad enough for me to discontinue. I would like to feel better, but I am hoping it will improve. Fatigue is the worst for me because I also have another autoimmune disease that causes extreme tiredness. I am taking a multivitamin and see my doctor in a week, and I will discuss negative side effects. Right now, the benefits of losing weight are worth it."

• Moo...
• May 20, 2019

For Type 2 Diabetes "On my 5th week of semaglutide, and my dose went from 0.25 mg to 0.50 mg as prescribed. I was taken aback by the first 3-4 days on 0.50 mg. After 4 weeks on 0.25 mg semaglutide with no significant side effects, but at the 0.50 mg dose, I developed strong nausea, weakness, and fatigue, and a feeling as if I was fighting the flu. My mobility and energy literally were quite impaired. By the end of day 4, I've noticed a slow, gradual improvement, and I was able to go out for some groceries. (Gravol for the nausea helped.) I'm hoping that I will continue to adapt to this medication because I really like its effectiveness for my diabetes. Since starting 5 weeks ago, my glucose dropped from 10+ to a new average of 7.0. I've also lost weight, my weight loss is already 10 lbs+, my stomach is flattening, and I can see other positive changes. This is the perfect med for me as it addresses my diabetes and is promoting noticeable weight loss. Overall, I am very pleased after 5 weeks on semaglutide."

• dru...
• Taken for 1 to 6 months
• January 28, 2019

For Type 2 Diabetes "In a drug study for weight loss. I am losing about 1-2 pounds a week consistently for the past 5 months (20 pounds so far). Side effects are worst 1-2 days after the weekly injection. Fatigue, nausea, gas... You have to eat plenty of fiber to not be constipated. I have also experienced vivid dreams off and on since starting the drug. I am torn between tolerating the side effects and losing the weight. I will try to stay in the study until I have reached an acceptable weight for my size and age. I would highly suggest it for the obese. Good luck!"

• tyn...
• Taken for 1 to 6 months
• January 12, 2023

For Weight Loss (Obesity/Overweight) "I have lost significant weight. I have not experienced the vomiting and stomach aches, nausea, but I have experienced extreme fatigue, muscle weakness, and soreness. I'm coming off the medication because of the muscle soreness."

• Txg...
• Taken for 1 to 6 months
• January 4, 2023

Semaglutide for Type 2 Diabetes "A1c crept up to 6.9. Started Rybelsus for a 30-day intro with fairly vague side effects of light nausea, constipation, and reduced appetite. Increased to regular 7 dosage and immediately side effects were extreme and awful. Constant significant nausea, abdominal discomfort, significant constipation, low energy. Almost no desire to eat, and if I did eat, even very little food caused even more discomfort that escalated. Food just sat in my stomach feeling heavy and sour. Heartburn and gas were constant. After just 5 days of a larger dose, I stopped the medication but with lingering side effects. After being off the drug for two days, I sustained immense abdominal pain like I have NEVER experienced that finally culminated in strange diarrhea. Too many intense and questionable side effects for me. Weight loss - by not being able to eat - not worth the escalating horrible side effects for me. I'll never take this drug again."

• Daw...
• Taken for 1 to 6 months
• May 17, 2022

For Weight Loss (Obesity/Overweight) "I was placed on semaglutide for weight loss. I began with 0.25 mg once weekly week one, increased to 0.5 mg week two, at that point, I began to experience intermittent nausea. This was bearable, and I was still able to maintain my calories. I was down 8 lbs at the beginning of week three. Week three, I increased to 0.75 mg and had a lot of fatigue. I felt like I was a walking zombie for three days. I realized at that time that I was not eating enough calories and made a continuous effort to meet my protein goal, and the fatigue went away. I have now been on the medication for nine weeks. I have kept the dose at 0.75 mg (the suggested max dose is 2.5 mg), and I am losing 2-3 lbs a week. I feel great, and all the side effects have subsided. I am reading that they peak and subside around four weeks. The initial titration period can be rough, but this was so worth it for me as I had weight loss resistance for years. I will have my lipid panel drawn next week and hope for a reduction there as well."

• NEW...
• Taken for 1 to 6 months
• March 7, 2025

Semaglutide for Type 2 Diabetes "I started out on 0.25 once a week and then 0.5 for two more weeks. I am now at 1.0. I experienced a little nausea in the beginning, but it has subsided. I find it interesting that I don't crave salty foods and actually turn them down. I am craving salads, which I find interesting. I've lost 7 pounds in 5 weeks, and now with the increase, about a pound every two days. The best part is I am on Metformin and Janumet, with a daily blood sugar averaging 340. With the addition of Ozempic, my average blood sugar has been at 122. My A1C has dropped from 11 to 9, all in a very short time. I suffered heart failure last year, and my refraction rate is now back to normal at 55 percent. I am now experiencing some fatigue, but that could just be my body adjusting to all the meds on board. I feel I now have a brighter future ahead, especially with the normal sugar level, and am planning to do a lot of outdoor activities this summer. I've also gone back to water aerobics and have my life back."

• Tre...
• Taken for 1 to 6 months
• March 28, 2024

For Weight Loss (Obesity/Overweight) "Loss of 25 pounds over 3 months. Sugar levels stabilized; was able to discontinue metformin. Significant decrease in joint pain due to reduced inflammation. Less brain fog. Some nausea and fatigue, however."

• Ano...
• Taken for 1 to 6 months
• July 25, 2025

Semaglutide for Cardiovascular Risk Reduction "BP and blood glucose levels are the lowest they have been in a decade while taking 0.25 mg weekly for a month. However, abdominal pain, nausea, loss of appetite, reflux, and loss of energy have been persistent and, at times, debilitating since starting on the drug. Additionally, heart rate is running 15-20 bpm higher constantly. Not sure the gains outweigh the loss of quality of life."

• ros...
• Taken for 1 to 6 months
• September 12, 2024

For Weight Loss (Obesity/Overweight) "Light constipation for the first 3 days. I started to eat mostly a protein and vegetable diet with lots of water daily. I noticed a small amount of satiety the first evening. 0.25 mg for 4 weeks, 0.5 mg for 8 weeks. For the first 6 weeks, I struggled with fatigue and insomnia pretty badly. I had a little nausea. Still overeating occasionally, once or twice a week, pretty badly. Then I started the 1 mg doses. This is where I am now. Pretty good food satiety, finally, I am experiencing the cessation of most food noises. If this satiety continues, I will try to stay on this 1 mg dose. 14 weeks in and 23 lb weight loss. Started at 5’1” 192 lb - now 170 lb. I’m really working hard on maintaining a healthy diet and moderate exercise. I’ve been struggling with a food addiction my whole life. This has the potential to be life-changing."

• BLE...
• Taken for less than 1 month
• May 5, 2023

For Weight Loss (Obesity/Overweight) "I am only on week 3 and have not seen any weight loss or appetite control, but I’ve read the first 4 weeks dosage is to acclimate your body. Today was the first time I’ve felt any nausea, and I did seem to be a bit fatigued, which I’ve combated by trying to get 7-9 hours of sleep nightly. I am using the injections."

• Cor...
• Taken for 1 to 6 months
• July 29, 2022

Semaglutide for Cardiovascular Risk Reduction "I used this medicine for 3 months to help me lose an excess weight of 30 lbs. I lost 10 lbs. Initially, I had a few side effects: nausea and indigestion. But by the third month, I felt really sick. I asked for blood tests because I was so exhausted. My blood tests were perfect. The indigestion and heartaches got worse. Eventually, it became unbearable. I'm burnt out, so it just made my condition worse. Zombie. For people who support it well, it's great. But if you have a digestive sensitivity, it's at your own risk. I last used the medicine 10 days ago, and I still have digestive problems and heartaches, as well as fatigue. But the fatigue was present before the use of this drug. I lost 10 pounds out of 30 pounds in a month and a half. Then I didn't lose any more, and I continue to be careful. The drug works for 7 days, so it's been 10 days. It is completely eliminated from our body after 5 weeks. It is especially the fatigue that causes me problems. But it's normal when you're still in indigestion."

• Che...
• Taken for 1 to 6 months
• August 24, 2024

Semaglutide for Type 2 Diabetes "Have been on Ozempic for about 2-3 months at 0.25. Experienced/experiencing: nausea, heartburn, fatigue, light-headedness, constipation. Nausea has calmed down but still occurs. Heartburn has developed over the last month and is definitely not subsiding. Seems I am always tired. Sometimes getting up, I become light-headed and off balance. Constipation is quite prevalent even with eating high fiber fruit and vegetables, and I am doing my best to drink plenty of water, starting with hot lemon water and honey every morning. I do not know if I would recommend this drug or not. Everyone is different. Thank you."

• C01...
• Taken for less than 1 month
• June 28, 2021

Semaglutide for Cardiovascular Risk Reduction "I am a week in; no appetite, nausea present but not as bad as the first three days on treatment, fatigue and constipation slightly. Will be back in a few weeks for update."

• Anonymous
• Taken for 1 to 6 months
• November 20, 2024

Semaglutide for Type 2 Diabetes "Extreme fatigue, no nausea, constipation, and diarrhea. Daily fatigue became very difficult to control. I had to lie down and rest 2 to 3 hours a day."

• Anonymous
• Taken for 1 to 6 months
• December 20, 2021

Semaglutide for Cardiovascular Risk Reduction "Had morning nausea and couldn’t drink much coffee and some fatigue after a few days, but it was worth it. Lost 30 pounds in 4 months and feel amazing."

• udg...
• Taken for 1 to 6 months
• February 14, 2025

Semaglutide for Type 2 Diabetes "Terrible nausea and violent diarrhea. Fatigue. Minor weight loss. Blood sugars stabilized."