Semaglutide and Fatigue: What Users Say (Page 2)

• Chr...
• Taken for 1 to 6 months
• January 9, 2020

Semaglutide for Type 2 Diabetes "I am 70, and I have been using Ozempic for over 5 months. After having horrible nausea, things have gotten better. I have to use samples as the cost is greater than I can afford. Now, my joints are paining, reflux, and low energy. My A1c is better, and I have lost a little weight."

• Kom...
• Taken for less than 1 month
• November 27, 2019

Semaglutide "Oh boy. I just started Ozempic for weight loss at .25. After my first injection, I was fine for two days, and then was constipated for two days—and since then I’ve been pretty darn sick. Violent diarrhea, headaches, some nausea, and very low energy. I’ve taken several days off from work as I’ve felt so bad. I’ve lost weight since I have no appetite, and nausea follows whenever I eat—even broth and crackers. I have international travel planned in 10 days, and I hope that I’m recovered by then. I may try again after my travels, but this has been rough. The worst side effects I’ve had from a new medication."

• Nes...
• Taken for 1 to 6 months
• May 3, 2019

Semaglutide for Type 2 Diabetes "Was diagnosed with type 2 diabetes in March 2019. Doctor put me on Ozempic rather than insulin, although it's not recommended. He thought it was worth a try along with 500 mg metformin twice daily. The first 3 weeks of 0.25 mg Ozempic were just fine. Very minimal side effects - occasional diarrhea, some gas, and belching. Nothing I couldn't handle. The fourth week of 0.25 mg was worse. Constant diarrhea for four days, nausea, some vomiting. I went to a different doctor thinking I had a stomach virus, he prescribed me an anti-diarrheal, and I felt better. I took the Ozempic at 0.5 mg then, as prescribed. Two days later, nightmare. Diarrhea again, vomiting, nausea, and serious fatigue. I'm in the throes of it right now, and I'm going to be contacting my doctor to see what I can do to counteract this. Besides the side effects, though, it's working beautifully. My blood sugar is down from the high 300s to the low 100s in just a month."

• Big...
• Taken for less than 1 month
• April 11, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "Took my injection .25 mg Friday afternoon and had a very hard time eating dinner. By noon Saturday, I was violently ill with diarrhea, vomiting, and a fever. The symptoms subsided by Sunday, and I was left very achy and fatigued. On the upside, I guess I did go from 335 lbs to 318 lbs over the course of the weekend. This medication is not for the faint of heart. It is very depressing to see a full-course meal in front of you and only be able to eat a few bites. If you are serious about losing weight, this medication will get you there, but I wonder if it’ll work or if the side effects will at least subside with longer-term use. The nausea is horrible, but you do also have some beautiful dreams while taking it."

• Geo...
• Taken for less than 1 month
• February 23, 2022

Semaglutide for Type 2 Diabetes "Been on Rybelsus 3 mg for 16 days. Sugars have improved somewhat already, and weight down about 5 pounds, unexpected. BUT, no appetite, stomach feels full all the time, hard to even drink enough water each day because stomach so uncomfortable. Constipation that is not very responsive to Miralax. Cold hands. Some nausea. More heartburn than usual. Increased fatigue. And the worst is: dizziness and/or vertigo and a feeling of weird fullness in my head along with tinnitus. What the heck? Given the high cost, and that I've all these effects even before going on the 7 mg dosage, I don't think it's worth it."

• Ley...
• Taken for 1 to 6 months
• June 3, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "From the initial starting dose until I went up to 1 mg, the whole 6 months was a roller coaster of nausea, headaches, and uncontrollable vomiting. The nausea was always followed by throwing up 5-7 times per day. If I ate or drank anything with too much sugar (including fresh orange juice), then I would throw it up within 30 mins. The sulfate mouth smell, along with the vomiting, was difficult and embarrassing. Exhausted and tired feeling, along with feeling depressed and hating/disgusted by food, is how I felt. I did lose about 8 kgs before moving on to Saxenda. Get ready for Ozempic to destroy your life for a few months if you want to lose weight with it."

• rav...
• Taken for 1 to 6 months
• September 10, 2019

Semaglutide for Type 2 Diabetes "I experienced severe stomach bloating and constipation after the first dose. I started injecting into the back of my arms and, with each subsequent dose, side effects lessen, though I still experience moderate nausea and fatigue after taking my weekly dose. On the positive side, my appetite has been reduced by at least 1/2, with 15 pounds lost. My fasting blood sugars are in the 80's and my post-meal levels rarely top 130. Even after eating small amounts of carbs, sugars fall to the nineties within an hour."

• Sar...
• Taken for less than 1 month
• April 10, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "Made me terribly sick. Took only 0.25 dosage one time, had terrible diarrhea, extreme exhaustion, and some nausea. Definitely not taking the second dose. Not worth the pain. Did not lose any weight either. It stops you from eating because it makes you feel so bad if you do. I also think this drug is meant for someone who doesn’t live an active lifestyle. I work out all the time, I eat healthy, and really just wanted to drop 15 lbs. This drug was very disappointing."

• C01...
• Taken for 1 to 6 months
• July 6, 2021

Semaglutide for Cardiovascular Risk Reduction "3 weeks in... Initially prescribed for weight management. While my appetite's drastically reduced, I've experienced headaches, some brain fog, and felt a little under the weather. Nausea slightly though it reduced day by day. Fatigue's unbearable. I typically have an upbeat, positive attitude and noticed a not-so-good version of myself just recently. Contemplating discontinuing treatment as excited as I am for the weight loss aspect of it :("

• 510...
• Taken for 1 to 6 months
• April 12, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I'm on my third month of Wegovy. The day after my injection, I usually puke at least once and sleep 10+ hours with extreme fatigue and nausea. I started in February 2022, and now it's April 2022. I went from 247 lbs to 222 lbs. 25 pounds. I get ill if I eat sugary foods with this. I eat three small meals a day, a plant-based diet, with around 5,000 steps a day and little to no exercise outside of work. I felt good usually a couple of days after injections, and by the third week at the same dose, I had no side effects. The first two injections at a new dose aren't easy for me. I have missed work and had a hard time watching my two-year-old due to puking and fatigue. I gave 10 stars because it does as it says with side effects you are aware of to begin with."

• Per...
• Taken for 1 to 6 months
• April 13, 2022

Semaglutide for Type 2 Diabetes "Ozempic has changed my life and put my diabetes in remission. I am 5 foot 5 and weighed 155 pounds. I now weigh 120. The downside is that it took me two months to adjust to the drug. I went from .25 to eventually a weekly dose of .50. Those two months were horrible, but I persevered. The symptoms were extreme nausea and fatigue. The other challenge is that I have to be sure to keep up my caloric intake so that I don’t continue to lose weight. I am at my ideal weight, but I want to maintain it rather than lose any more."

• Eve...
• Taken for less than 1 month
• May 21, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I was recently put on a generic form of Ozempic for weight loss. I’m prediabetic and have tried other forms of weight loss programs that were not sustainable. It’s day 3 now, and although I feel fatigued, my appetite is substantially reduced, and I don’t have nausea anymore. The nausea is actually almost non-existent. I only get it in the morning right after I wake up, and it goes away within minutes. I’m honestly amazed by this medication, but I’m just concerned about the long-term effects of it, such as cancer."

• Goa...
• Taken for 1 to 6 months
• July 20, 2021

Semaglutide for Type 2 Diabetes "I have taken 7 doses of Ozempic. The first week wasn't too bad. A little nausea and fatigue. I did feel like my food stuck in my throat, and every time I burped, there it was. As I continued to take it each week, the side effects got worse. I was just diagnosed with diabetes in May, and since then, I've been able to come off of my insulin on my own, before Ozempic. I still take Metformin twice a day. This past week, the seventh dose made me so sick! If I wasn't nauseous every day, I was running to the bathroom at all hours of the day and night. I had horrible heartburn, gas, burping, jitters, and dizziness the whole time and thought I could continue, but after this past week, my doctor said to come off of it. It will take a while to get out of my system, I know, but I hope it does so quickly. I need my life back!!"

• Big...
• Taken for 1 to 6 months
• May 23, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I started Wegovy (2.4 mg) 5 months ago, weighing in at 417 lbs. Today I'm down 82 lbs. Not bad for no exercise and extreme dieting! Wegovy is NOT for the weak! My first dose almost canceled me completely out of the plan! I experienced severe nausea and vomiting the first 3 days, accompanied by fatigue. I felt horrible, but I chose to stick it out after I stepped on the scale and saw amazing results! After the first month, my vomiting stopped, however, if I ate anything that didn't agree with me, it would come up. I still experience nausea, for which I take Zofran to help keep it to a minimum. The most important thing I love about Wegovy is it makes me think about what I'm going to put in my mouth and if I'm even hungry. I have to remind myself to eat a little something, but most of the time I'm not hungry at all. Most of the time, I'll make a plate and only take a few bites, wrap it up for another time. If you are serious about losing weight, Wegovy is the way to go!"

• Jef...
• Taken for less than 1 month
• June 26, 2024

Semaglutide for Type 2 Diabetes "Started with a 0.25mg dose once a week. I am on week 3 of taking it and already noticed a decrease in appetite and sporadic increase in feelings of nausea. I also have noticed that I get full quicker resulting in eating less. Bowel movements are no longer consistent and can vary in type. I have noticed that I have moments where I have no energy. In order to try and improve this, I have been drinking a little orange juice. I continue to drink a lot of water since I also take Jardiance, which will dehydrate you if one doesn't drink enough."

• vtn...
• Taken for 1 to 6 months
• May 29, 2024

Semaglutide for Type 2 Diabetes "One month on Rybelsus. Blood sugar levels are down from 150 to 116-96. I have extreme nausea, constipation, and I am unable to eat more than 1-2 cups of food at a meal. I am rarely hungry. Food seems to become lodged in my esophagus and is painful. I have lost 13 lbs. in a month. Fatigue is an issue. My autoimmune retinopathy, which surfaced after cataract surgery, is worse. I fear I will not be able to continue this med."

• Anonymous
• Taken for 1 to 6 months
• June 4, 2024

Semaglutide for Type 2 Diabetes "On the plus side, Ozempic quickly began to lower my blood sugar, which metformin alone was no longer able to do, despite exercise & diet control, so that I was back into more normal numbers. I still take metformin. I had some constipation, but worked through that issue & mild nausea also appeared, but then disappeared. My overeating for stress & or boredom was much easier to manage, I thought about eating poor choices & then was able to push the thought away. The biggest challenge was fatigue, I often am feeling very sluggish & sleepy & have to push through chores like grocery shopping. I’ve lost 5 lbs in 2 months & want to lose 15 more lbs to achieve my goal, so I hope the fatigued side effect will diminish. Easy to learn how to administer from the instructions. I’m on 0.5 dosage & believe I will increase to 1 dosage within the month."

• Mar...
• Taken for 1 to 6 months
• February 4, 2025

Semaglutide for Type 2 Diabetes "I have been on Ozempic for 6 months. My A1C was 10, it is now 6.9. I thought it would be lower after 6 months. I have lost 45 lbs. because it killed my appetite, so some days I don’t eat at all. Side effects: diarrhea after eating, nausea, fatigue, just feeling blah."

• Jea...
• Taken for less than 1 month
• June 7, 2023

Semaglutide for Type 2 Diabetes "Nausea, bad acid reflux at night, nightmares, headache every morning, constipation, chills, fatigue. Just started a week ago. Blood sugar levels in the 80s and 90s. Have lost no weight. Zero appetite. Blurry vision."

• Jen...
• Taken for less than 1 month
• August 19, 2021

Semaglutide for Type 2 Diabetes "I was prescribed Ozempic for Type 2 diabetes to help lower my blood sugar and to help with weight loss. The first week wasn't so bad, just a little fatigued and some upset stomach problems. The second week it kicked in overtime and hit me like a brick wall. I had no energy at all. Stayed in bed because it's all I could do. My stomach was so upset and nausea, vomiting, and diarrhea were so bad, it ran like water. I became more dehydrated with less energy. I have 4 autoimmune diseases and this was the sickest I have ever felt in my life. I almost went to the ER and if not for Covid, I would have. It felt like someone had been feeding me rat poison. It's the worst feeling ever. I truly don't know how this drug was approved by the FDA. I plan to take myself off it. Weight loss and blood sugar need to be done in a healthier manner. Lose weight fast and easy has consequences."

• SuT...
• Taken for less than 1 month
• August 4, 2021

Semaglutide for Type 2 Diabetes "I have been on Rybelsus for 11 days now. The first few days were horrible. I had diarrhea and stomach pains, even threw up twice. I am still having side effects on day 11 but not as bad. I’m taking Zofran for the nausea. I have already lost 8 lbs, which I’m sure is not healthy, but I don’t have an appetite on this medication. Before this medication, I would eat all the time, it seemed like I never was full. My sugar levels are as low as they’ve ever been. I am tired and have lower energy. I'm hoping after another week on it the side effects will subside. I have been struggling with weight loss my whole adult life and can never break through the plateau phase. I think this medication will help if I can withstand the side effects."

• Suz...
• Taken for less than 1 month
• July 22, 2021

Semaglutide for Type 2 Diabetes "I’ve taken two doses of Ozempic .25 mg and been on the drug for 1 1/2 weeks. I won’t be able to continue. This is a very harsh drug, and the side effects are terrible, in my opinion. I did not suffer from nausea and vomiting but couldn’t eat, food tasted horrible, my body stopped absorbing fat (evidenced in my stools), had lightheadedness, and the worst fatigue imaginable. In 1 1/2 weeks, I’ve dropped 10 pounds and feel undernourished and dehydrated. Be careful!"

• Kat...
• Taken for 2 to 5 years
• October 10, 2024

Semaglutide for Type 2 Diabetes "I have been on Ozempic for Type 2 diabetes. Was overweight as well, I am 4'11 and had ballooned to over 170 pounds. I was taking medicine for blood pressure, anxiety, depression, you know, all the things. I started in March 2022. My A1c was 7.9. Today I am down to 105 (hold up, that is normal for my height). No more high pressure. Beginning, I wasn't sure I would get past the nausea, but I fought through it, and yes, it does go away. I have been on stool softeners for a while, so I have never had any issues going to the restroom. My A1c is 5.4 now. I don't feel good, though. I can't put my finger on it, but I am severely exhausted and fatigued. I will not trash this medicine because I think it works as it should and has been amazing for diabetics. I just wish I didn't feel like poo all the time. The side effects do subside over time. My doctor and I have found the perfect dosing and schedule for me to keep my blood sugar under control."

• Apr...
• Taken for 1 to 6 months
• August 25, 2021

Semaglutide for Type 2 Diabetes "I have been on Ozempic for 20 weeks now, and I still experience bloating, flatulence, nausea, and fatigue. My A1C went back to normal, but I feel sick all the time. My most horrible side effect is the rotten egg smell of my burps. I am also taking Toujeo and Janumet."

• Zam...
• Taken for 1 to 6 months
• September 6, 2024

For Weight Loss (Obesity/Overweight) "I've been on semaglutide for nearly 4 months. I struggled with fatigue, nausea, and constipation the first few weeks. I almost gave up, felt like I'm wasting my time and money. Honestly, the change felt like it happened overnight, I looked in the mirror and saw a different me. I feel lighter, and my tummy feels soft. I struggle with back pain, but it's calmed down already. I feel happier and more active. I'm far from my goal, but definitely sticking to this. My appetite has reduced a lot. It won't work overnight, but it sure does work. Giving myself 8 more months, I'm confident I'll have my body back. Eating healthy and keeping up helps. Love this, it works for me, and it can work for everyone."