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Semaglutide User Reviews & Ratings (Page 4)

Brand names: Ozempic, Rybelsus, Wegovy

Semaglutide has an average rating of 6.9 out of 10 from a total of 2,744 reviews on Drugs.com. 56% of reviewers reported a positive experience, while 20% reported a negative experience.

Reviews for Semaglutide

Commonly mentioned side effects
  • She...
  • Taken for less than 1 month
  • July 9, 2024

For Weight Loss (Obesity/Overweight) "I’m on the starter dose 0.25 mg. I have had zero side effects. Mild nausea in a car - not sure if related? No real appetite, but I am able to eat. No food aversions, but no cravings. I didn’t want a glass of wine after work. My clothes already feel different after 2 weeks. I’m so thankful to be on this journey as my primary did not support me asking for help losing weight. I do not overeat or have issues with food. I had a fractured knee, then a hip replacement, and then two fractured ankles. I was unable to move normally for 2.5 years and gained about 50 lbs. The weight gain brought on joint pain, trouble breathing, sleep apnea, afib, raised blood pressure, and cholesterol. Hopefully in 6 months, I will be down 40-50 lbs."

10 / 10
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  • Tom...
  • Taken for 6 months to 1 year
  • April 13, 2023

For Weight Loss (Obesity/Overweight) "Started Wegovy in March 2022 with a goal of losing 50-75 pounds. I ended up losing a total of 85 pounds in about 11 months. I felt great upon taking the Wegovy. Only had mild headaches and mild stomach discomfort. I was not tired, I actually felt energized. However, by December, the nausea had reared its ugly head. I took Zofran, and it helped. I was able to stick it out with the nausea until February, at which time I stopped taking it. I could no longer live with the nausea. Since I stopped taking it, I have continued to suffer nausea, vomiting, and stomach pain. My doctor and I are still trying to find the source of this continuing issue. I love the weight loss, and I love Wegovy!"

7 / 10
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  • Sos...
  • Taken for 1 to 6 months
  • March 7, 2023

"I was nervous taking this given previous reviews. My doctor started me on the 3 mg tablet. Initially, I felt a bit nauseous, but I was told to wait an hour to eat. The nausea went away. Immediately by the 3rd day, I could tell I wasn’t as hungry as before. I don’t look for snacks, I don’t overeat my dinner, and I get full faster. I'm on my second month and now up to 14 mg. The boost of energy I’ve had has helped me get back to exercising 3-4 days a week and walking almost every night for an hour with the dogs. I started 1/19 and weighed 183. It’s 3/7 and I weigh 158. It’s not all the pill, but the pill certainly boosted my energy, which in turn helped me get back on my feet to move around more. The best part is my insurance covers it completely. I feel like a new me."

8 / 10
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53 Report

Frequently asked questions

  • Too...
  • March 21, 2023

For Weight Loss (Obesity/Overweight) "My first dose made me sick as a dog two days after the injection. Nausea, felt like I could vomit, and kept swallowing over and over again. Cold chills, it was awful! I do not plan to continue. No pain, no gain. I’ll get my loss the old-fashioned way with proper diet and exercise. Never again want to feel this way on Ozempic."

1 / 10
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55 Report
  • Mal...
  • Taken for 1 to 6 months
  • August 21, 2024

For Weight Loss (Obesity/Overweight) "I'm 60 years old, started taking Wegovy for weight loss, high blood pressure, high cholesterol. I’ve been on the medication now for 10 weeks. My starting weight was 296. Currently, I weigh 266, and my numbers are great. The cons are I only feel good 4 days a week. The first 3 days after the injection are tough: nausea, headaches. But as far as I’m concerned, it works great. I’m not hungry at all. I feel much better. Another added bonus for me was I was a heavy drinker. On this medication, I have no desire to drink at all. I went from 5 cases a week to absolutely nothing. I don’t miss it at all. Miracle drug."

10 / 10
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  • Tan...
  • Taken for 1 to 6 months
  • May 12, 2022

For Cardiovascular Risk Reduction "I have been taking Ozempic since March 12, 2022. I started at the .025 dose for 4 weeks. I had a little nausea, but nothing serious, and some constipation. I have now been on the .050 dose and have very little appetite, and no other symptoms have remained other than occasional constipation. I have to remind myself at times to eat. I have more energy than I have had in years and feel so much better in my clothes. Since March, I have lost 25 lbs. This has been a life changer for me as I feel so much better. I am still 45 pounds from my goal weight, but this drug has definitely helped me. I give the shot in my thighs, as I have read many comments on here to do so for fewer symptoms, and I believe that is why I have done so well."

10 / 10
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  • JAO...
  • Taken for 1 to 6 months
  • June 14, 2023

For Weight Loss (Obesity/Overweight) "I had been on this drug for 4 months. Typical escalation dose until month 4, I stayed on the 1 mg. The side effects were rough since increasing to 1 mg. So much nausea, worsened reflux, constipation, bloating, burping, and indigestion. I vomited once, but there were a few times I almost did. In the last few weeks, I noticed hair loss. Noticed skin tags that I have never had...like 3 grew since the med. Weird. Oh, and I had serious issues with certain smells. I had to change out the hand soaps in my house 5 times. If I smell rubbing alcohol, I am instantly nauseous. Just looking at the Wegovy box before injecting would make me dizzy and nauseous. So weird. Difficult to eat healthy on this med due to side effects, and only able to tolerate simple carbs, low-fat diet. Also hard to work out when feeling so nauseous...so didn't think it was contributing to my health. Has not really contributed to weight loss, and appetite is almost the same as before med."

1 / 10
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More FAQ

  • Fif...
  • Taken for less than 1 month
  • August 29, 2021

For Type 2 Diabetes "On week 4 now, honestly, the first 2 weeks were a nightmare. Doctors don’t tell you to stay away from fatty foods and not to overeat. If they did, I wouldn’t have had the most horrible sulfur burps that made my eyes water, projectile vomiting, diarrhea, and stomach pain, not to mention constant nausea even during the night. I finally figured out not to eat too much and to avoid fatty foods completely! This was a game changer, and now I’m doing okay. I've lost 21 pounds so far, which is mad, but mostly because in 2 weeks I’ve eaten probably 4000 calories. I’m back to wanting to eat again but have to control myself or face the terrible consequences. Blood sugars are all over the place, as you can imagine, however, insulin sensitivity is way better. It just takes time to get used to. Hope this helps."

6 / 10
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  • Bit...
  • Taken for 6 months to 1 year
  • March 23, 2025

For Weight Loss (Obesity/Overweight) "I started Wegovy in April 2024. I was 193 lbs at just between 5’1”-5’2.5. I had tried everything, but food noise and the fact that being so short, the calorie intake had to be so low to lose weight. Anyway, the first thing I noticed was a bit of nausea. That went away after a few days. I have had very minimal side effects. Sometimes a little nausea, constipation, or diarrhea. Nothing to really disrupt my life. For the first time in my life, I actually can tell when I am full. My IBS has been almost non-existent. I’m more awake. I have fewer sweet cravings. The food noise is still there, but my stomach is able to signal my brain that if I eat more, I will feel sick. I have lost to date 4/2024-3/2025, 63 lbs. I am just about to hit my normal weight goal. I knew how to lose the weight. I am someone who has a very difficult time shedding the weight with exercise and diet. I am super grateful for this opportunity to prove that a drug works so well."

10 / 10
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  • Mim...
  • Taken for 1 to 6 months
  • September 19, 2023

For Weight Loss (Obesity/Overweight) "Wegovy is working great! Very important to hydrate and have a lot of fiber. Also, control your portion size; you cannot eat large portions. I'm following a strict 1300 calorie lifestyle change. From June 17, 2023, to present (Sept 19, 2023), I've lost 30 lbs. The injections are simple and virtually painless. I'm currently on 1.7 and I have little to no side effects. I inject every Saturday night before I go to sleep. I read that taking medication before bed reduces nausea and for me, it has worked. The only side effect is that I have absolutely NO desire to drink alcohol. The best side effect ever! I've already stopped taking blood pressure medication, cholesterol medication has been reduced to the lowest dose, and my A1C is out of the pre-diabetic range and within normal limits, and I'm only halfway to my weight loss goal. All medication has been stopped or reduced by my physician after blood work. Very happy!"

10 / 10
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  • Los...
  • November 10, 2019

For Type 2 Diabetes "I am a 70-year-old type 2 diabetic and was taking one Metformin 500 ER for the past year or so. My A1C was 11, and it dropped to 5.6 by changing my diet and taking the Metformin. My doctor wanted me to try Ozempic to help me lose weight and possibly eliminate the Metformin. The side effects were terrible right from the start. Nausea and diarrhea, no vomiting, just nausea. I started at 0.25 and am now up to 1.0. My appetite is gone completely. I have no desire to eat at all. When I do eat, I get full almost immediately. I have gone from 228 lb down to 202 lb in the six weeks I have been taking Ozempic. I'm thrilled with the weight loss, and the nausea and diarrhea have improved. However, I have almost stopped peeing. I go in the morning, then go all day into the evening without going. Since I suffer from incontinence, it's good, but I am worried that it might be damaging my kidneys. I hope I don't have to stop taking it, at least till I lose another 50 pounds or so."

7 / 10
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  • Nur...
  • Taken for 1 to 6 months
  • July 15, 2023

For Weight Loss (Obesity/Overweight) "Ozempic for weight loss is AMAZING! I have tried everything for weight loss since 1985. Ozempic by far is a miracle for me. It immediately blocks cravings, appetite, and thoughts about food! I started June 2, 2023 and today, July 13, 2023, I lost 22.3 lbs. This is a 6-week success story! I took 0.25 for the first week and then 0.5 weekly on Sundays. I have stayed with Weight Watchers, mainly selecting 'free foods'. If you are eating out with friends this summer, remember that rich, high-fat content foods will give you immediate abdominal distress (cramps, diarrhea). So, I've learned to go through restaurant menus and find something less distressful to eat so that I can enjoy time with friends and family. I have Zofran for nausea, but for me, the nausea passes and I do not use anything for nausea. Stay active at least walk! It's free! Keep drinking water and add a packet of electrolytes due to this extreme heat this summer! Check-in with my doctor on a regular basis."

10 / 10
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  • Lau...
  • Taken for 1 to 6 months
  • April 1, 2020

For Type 2 Diabetes "I have been prescribed Ozempic for weight loss secondary to type 2. I got nauseated with some loss of appetite at 0.25 mg dosage and adapted to it over a month. Lost 9 lbs in that month. I increased to 0.5 mg last Friday (it is Tuesday), and I am miserable. Non-stop nausea, burping, some pain in the stomach, constipated. I feel miserable. I am worried about the stomach pain being pancreatitis starting, so I am increasing my water. I haven't eaten in two days. I will not continue with this drug as I think this just cannot be a good thing to do to one's body."

3 / 10
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  • Pat...
  • July 19, 2019

For Type 2 Diabetes "Started taking Ozempic for pre-diabetes and insulin resistance. This is the first medication I've ever taken for diabetes. A1c was 5.7. I increased the dose quickly at the doctor's recommendation if little to no side effects occurred. First dose 0.25 in the office. Second 0.5 a week later. Third dose at 1.0 a week after that. Only side effect I have is mild nausea. Appetite has disappeared, and I eat only when hungry and much smaller portions. Serious bloating when I eat too much, which is a great deterrent. Been on the medication for 4 weeks overall, 2 weeks at 1.0, weight dropped from 305 lbs. to 295 lbs. Still a little lethargic, but I was very lethargic before starting the medication. I feel like this medicine is a game changer for me. I love not thinking about food all of the time, only eating when hungry and not for pleasure, and losing weight. Will retest A1c in 2 months. Hopefully, the weight loss continues, and I caught the A1c level before it turns into full-blown diabetes."

10 / 10
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  • Sen...
  • August 29, 2019

For Type 2 Diabetes "I've been taking Ozempic for about 2 months to lower my Diabetes 2. It's been great, my numbers were 200 to 300, they are now 100-134. My A1c was 9.8, it is now 6.1, and I've lost 12 lbs and still losing. I'm also taking Synjardy XR, a combination of (Metformin & Jardiance), my numbers are great. I eat extremely less on the Ozempic. My only side effect has been an occasional headache, but nausea was brutal. I was getting very nauseated after eating and taking Synjardy XR until I heard about ZOFRAN. Let me just say, if you have nausea and are taking Metformin with Ozempic, PLEASE ask your doctor for a prescription of ZOFRAN (I got the generic ONDANSETRON 4mg). I take it 20 minutes after I eat and have taken my metformin. I NO LONGER get nausea. Zofran will definitely help with nausea if you're feeling sick. You'll thank me later."

10 / 10
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  • Mac...
  • Taken for 1 to 6 months
  • September 14, 2019

"I am pre-diabetic with high blood pressure, high triglycerides, and high cholesterol. I’ve taken Ozempic for 3 1/2 months to help me lose weight. My weight loss is 32 lbs. I am never hungry, and when I eat, my tummy gets full very quickly. Because I’m not hungry, I have used this time to learn the art of healthy eating. No fad diets or keto. My blood pressure is now normal, and I am off BP pills. My triglycerides dropped 150 points. I have had no side effects other than constipation. I now drink 3 liters of water each day and eat insoluble fiber to control it. My husband is diabetic and has been on it for 6 months. He experienced side effects such as nausea and dizzy spells, but it lasted around 3 months, and he no longer has them. His A1C was 9.5 before Ozempic and is now 6.7."

9 / 10
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  • Val...
  • Taken for less than 1 month
  • February 14, 2020

For Type 2 Diabetes "I’m a nurse. I started this med and unfortunately the nausea, gastritis, dizziness, and headache continuing into week 4 is simply not worth it. I can’t lay in bed and be miserable, which is what this does to me. At first, I actually thought I had a GI Bug. If there is any other choice, do not put yourself through this."

5 / 10
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  • Bar...
  • Taken for 1 to 6 months
  • March 24, 2023

For Weight Loss (Obesity/Overweight) "I have been taking Ozempic for six weeks. This will be my second week at 0.50 mg, and I have lost 10 lbs. At 0.25 mg, I had minor nausea and was very tired but felt fine otherwise. After my first 0.50 mg injections, I could not drink, eat, or do anything for the first day. I had a lot of nausea and felt like I was going to be sick constantly. By day 3, I had to go to the bathroom about nine times, which was good because constipation is a real thing with this medication. By day 4 and on, I felt perfectly fine. I do watch what I eat, and the medication has cut my food intake by half. You have to pay attention to what your stomach is telling you."

7 / 10
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  • Mic...
  • Taken for 1 to 6 months
  • June 7, 2023

For Weight Loss (Obesity/Overweight) "I had a horrible experience. Abdominal pain going to the back. Constant nausea. Depression - very strange feeling, almost like an out-of-body experience. For the first time, I found myself HATING my body. Extreme tiredness. Difficulty focusing. Gained 9 pounds in 3 weeks. Constant headaches."

1 / 10
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  • Jan...
  • Taken for 6 months to 1 year
  • May 26, 2021

For Type 2 Diabetes "I started Ozempic in July 2020. The first few weeks, I had slight nausea. Now, 10 months in, I’ve lost 50 lbs - from 210 lbs to 158 lbs, and my sugar levels, if anything, are on the low side. I’ve just stopped taking my Metformin as they were dropping too much. I didn’t even make it to the 1 mg, stopping at the 0.5 mg. If you can last the first 4 weeks, it’s amazing. The only side effect I have is a little constipation, which I control with PEG when needed. It has changed my life! I feel like a brand new woman!"

10 / 10
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  • Onw...
  • Taken for 1 to 6 months
  • July 18, 2021

For Type 2 Diabetes "I am male (early 50s). Blood glucose was already regulated with metformin, diet, and exercise (100 to 150), but I wanted to quit metformin because of its side effects (diarrhea). I was put on 0.50 mg/wk and warned that nausea from Ozempic was a common side effect. I had no idea! Week 1/Week 2: I couldn't smell food without getting queasy. I choked down lots of soup just to get 1200 cal/day (often falling short). Week 3/Week 4 got slightly better. Week 5: I have my appetite back. I feel full, so I eat smaller meals. My weight loss is atypical: 203 lbs to 183 lbs in five weeks, combined with exercise (1 hr/4x wk stationary bike/treadmill). Blood glucose is now between 90 and 120, with occasional dips and peaks. I would only recommend this drug to those who have very high glucose levels, are morbidly obese, fiercely stubborn, and/or desperate. But it works. Good luck."

8 / 10
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  • Cas...
  • Taken for 1 to 6 months
  • January 18, 2021

For Type 2 Diabetes "Ozempic has been a life-changing medicine for me. My A1C is better controlled, and I have lost around 13 pounds so far and have not even been on it that long. Before Ozempic, I craved sweets and was constantly hungry, Ozempic has greatly helped me regulate my appetite. If I eat too much, I do have problems with nausea, so I do have to be careful, but that’s a good side effect, I think."

10 / 10
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  • Isa...
  • Taken for 1 to 6 months
  • September 24, 2020

For Type 2 Diabetes "My endocrinologist prescribed 3 mg to start because the B12 depletion from metformin (I have B12 anemia) was not good and constant yeast infections from Forxiga were very annoying. At first, I noticed a major appetite decline. There was a bit of nausea for the first 2 weeks. I started the 7 mg after a month and while I've been experiencing constipation, I am so happy about the weight loss. I've been on Rybelsus for 10 weeks and have lost 10 lbs. My latest random glucose test had me at 5.7, down from 6.3 - 7 over the previous few months. I am happy about fewer carb cravings and will stay on Rybelsus as long as I can. I am lucky my health plan covers it because it's quite expensive."

10 / 10
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  • 188...
  • Taken for 1 to 6 months
  • May 17, 2023

For Weight Loss (Obesity/Overweight) "Started Wegovy 3 months ago using the gradual phase-up method. From 0.25 mg dose for 4 weeks to 0.50 mg dose for 4 weeks, then 1.0 mg dose for 4 weeks. During the initial phase, I experienced mild nausea and some stomach irritation. With each increase, the symptoms got worse until finally, at the full 1.0 mg dose, I was so sick I thought I had stomach flu for 2 weeks continuously. The belching was horrible. The nausea caused uncontrollable vomiting, and I had frequent diarrhea. After 3 months, I lost 12 pounds and felt horrible every day. I've now reduced the dose to 0.5 mg but still suffer from nausea and stomach upset. I might cut back again, but I'm thinking I will quit. The way I feel all the time is horrible! I'm thinking I lost weight because of all the vomiting. Not recommended."

1 / 10
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  • Dim...
  • April 7, 2020

For Type 2 Diabetes "Been using Ozempic for 7 weeks, lost 12 pounds. I also take Xigduo and Lantus at night. Gas, nausea, headache, and a few low A1c. But my number is down from 8.1 to 5.4. For the gas, I find that Gas-X helps. And for the nausea, I sip on cold water and keep my meals small. I haven't thrown up yet and no constipation or diarrhea."

5 / 10
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