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Semaglutide User Reviews & Ratings (Page 3)

Brand names: Ozempic, Rybelsus, Wegovy

Semaglutide has an average rating of 6.9 out of 10 from a total of 2,744 reviews on Drugs.com. 56% of reviewers reported a positive experience, while 20% reported a negative experience.

Reviews for Semaglutide

Commonly mentioned side effects
  • Jan...
  • Taken for 1 to 6 months
  • March 15, 2021

For Type 2 Diabetes "My doctor gave me Ozempic 0.5 to start with. I always had upset stomach, diarrhea with most foods, and an overall sick feeling all the time. I was able to 'live' with it until now. She decided to up my dose to the 1.0 and my body went into total chaos. I am always nauseous, constipated, got reflux, feels like my food is stuck in my stomach and doesn't go anywhere. I'm constantly burping and feeling bloated. The sick feeling feels intensified and I cannot function at work. I took my last one this past Friday night and was miserable all weekend long. Today I am at work unable to function at my best because the nausea is bad. I would say it is effective in lowering your blood sugar numbers and helping you lose weight but not worth feeling horribly sick over. I will not be using this medication any longer."

5 / 10
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  • Cal...
  • Taken for 1 to 6 months
  • September 21, 2019

For Type 2 Diabetes "Since starting Ozempic, all my numbers have gotten considerably better. I did have nausea for several months, but I took medicine to counteract the nausea, and now I’m feeling much better. My appetite has been cut in half. I have lost a total of 40 lbs so far, and I couldn’t tell you the amount of inches I have lost, it seems that I lost inches first and then weight. I have started going to the gym. My advice to anyone starting Ozempic is to stop eating as soon as you get that first feeling of being full, don’t try to finish the plate just because you don’t want to waste food because it will make you sick if you force yourself to eat it all."

9 / 10
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  • Eri...
  • Taken for 1 to 6 months
  • March 29, 2023

For Weight Loss (Obesity/Overweight) "I've been on Wegovy for a little over a month now. My first injection of the 0.5mg dose was on Friday (3/24/23). The weight loss has been fairly slow but steady. The main thing that I've noticed is that it makes me feel full after I eat. I know it sounds strange, but for some reason, I've never felt hungry or full-I ate when people told me and didn't stop eating until my plate was clean since I was a kid. Now, after I eat a bit, I feel full and stop eating. I've learned to be choosier with what I eat, opting for healthy things, protein and fiber, and less fat and carbs. No crazy fad diets or anything, just being more mindful. My injections are on Fridays, and I've noticed that Sundays are the worst days, but after 2 weeks on a dose, the side effects are pretty minimal. Just started the 0.5mg dose and so this past Sunday was bad, but my doctor gave me a PRN script for Zofran to help with nausea. I hope this review helps someone."

8 / 10
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Frequently asked questions

  • Soo...
  • Taken for less than 1 month
  • July 8, 2021

For Cardiovascular Risk Reduction "I've been on Ozempic for just over a week now as part of a physician-run weight loss program. I was told to expect some GI upset, but I had no idea it would be this bad. Seven days after taking it, I started with diarrhea. One day after injection number 2 (2.5mg), I was up all night with diarrhea, nausea, severe reflux, belching, and eventually vomiting. Medications like Pepto can't seem to touch it. I am going to talk to the doctor next week and see what he thinks. I really don't think it is worth this kind of suffering."

2 / 10
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  • Shy...
  • Taken for 1 to 6 months
  • November 1, 2021

For Weight Loss (Obesity/Overweight) "Been on Wegovy for 7 weeks. Lost 14 pounds. 2nd week into 0.50 mg. It’s a little rough on my stomach. Taking prescription for nausea which happens the day of the injection. Feel tired and occasionally get severe abdominal pains. I can’t eat much and have to really watch the types of food. No greasy foods or spicy or heavy. The intestinal pains were very severe after eating wrong foods. I’m happy with the weight loss but the side effects are rough."

8 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • April 23, 2023

"I suffer from bulimia and binge eating. It’s amazing the potential of this medication that should really be looked at. I’m maybe 15 pounds overweight, but the obsession I had with food was unreal. Just constantly thinking about it, hiding, overeating, controlling, and throwing up when overeating. I have no side effects on Ozempic at all. I mistakenly started at 1 mg because I didn’t know how to click. No nausea, no other issues whatsoever, but I know people that couldn’t tolerate it. Yes, I lost a little weight, but mostly I stopped caring about snacks, carbs, or sweets. I eat when tired and need energy or when it’s been long enough, I don’t go crazy when I see food. It's saved my mind so much. I just live now and do not have a million thoughts in my head about bingeing because it’s there or hiding so no one sees how much I can eat."

10 / 10
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  • Sai...
  • October 17, 2020

For Type 2 Diabetes "Dr. ordered 3mg 30 days ago to be added to Metformin 2000mg. Blood sugars have decreased from a range of 200-350 to 120-150. Weight reduced by 14 pounds. I experienced nausea and fullness for the first two weeks. That has tapered off but appetite suppression has continued. After a month, the doctor is pleased with the results, as am I. He has ordered me to continue on the 3mg and my insurance has agreed to cover it with a copay I can afford. I am so grateful for this new med!"

10 / 10
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More FAQ

  • poi...
  • Taken for less than 1 month
  • April 3, 2023

For Weight Loss (Obesity/Overweight) "Been on Wegovy for half a week. For my first injection, I used the upper right side of my stomach. Within an hour, I had a bit of shooting pain in my left mid-back section. I was a bit concerned but didn't say anything to anyone about it as I figured it was just my body getting used to a new chemical. I'm now on day 3, and no pain anywhere, no nausea, and feeling pretty great. I am a little concerned about not understanding exactly what my caloric intake 'should' be but will discuss it with a dietitian. My dosage was the starter 0.25 mg, and my starting weight is 228 lbs. Let the journey begin! Already got past one of the biggest hurdles, namely doing the injections myself. The needle is super small, and didn't leave any marks or blood! Super fast, and recommend it to the 'needle-adverse' folks. I am very glad that it is only once a week though."

8 / 10
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  • Ano...
  • February 26, 2022

For Type 2 Diabetes "Reading many of the reviews frightened me so I thought it was important to share my positive experience. I’ll first say, I’m horrified of needles. However, you can’t feel the needle at all, the medication going in sort of burns a bit, but that’s it! I’ve been on Ozempic for 5 months. I started at 254 lbs and started taking 0.25mg for 6 weeks. No side effects in the slightest. I also didn’t lose much either though because it is your body getting used to the medication rather than fixing your blood sugars. I then moved up to 0.5 and started seeing results with my weight and still no bad side effects other than eating less. I recently moved up to 1mg and am now down a total of 45 pounds in 5 months. Still no bad side effects. Eating has to be much more mechanical though because my hunger cues aren’t as strong, but no nausea. I would highly recommend this drug! Ps inject in your thighs, I believe this is the reason I’ve had no bad side effects my entire journey!"

10 / 10
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  • Tou...
  • Taken for less than 1 month
  • March 14, 2023

For Weight Loss (Obesity/Overweight) "I am on my 3rd 0.25 dose of Wegovy. I feel terrible most of the time. I have lost 5 lbs and am definitely not hungry due to nausea. My prescriber will not prescribe Zofran with Wegovy because she feels nausea that severe should be considered a negative side effect and the medication stopped. That's reasonable. I read the reviews before I began the med and take Omeprazole daily, as well as Miralax. I am 57, menopausal, and used to feel really good most of the time. Sadly, this med is not worth the side effects for me. I really, really wanted to tough it out, but as a nurse, I feel it's creating problems that I did not have before taking this medication. The nausea is constant, the belching/burping is so frequent that it's embarrassing, stools are like a rock, and the worst feeling is chest tightness. I had so hoped I would be one of those without adverse side effects, but I am not."

3 / 10
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  • Wag...
  • Taken for less than 1 month
  • April 5, 2023

For Weight Loss (Obesity/Overweight) "I took my first shot of 0.25 five days ago. I was extremely nervous about taking it due to all of the negative side effects that I read others have had. I decided to inject in my upper thigh late on a Friday afternoon so that if I did feel sick, I had the weekend to take it easy and deal with it. The injection was painless and very easy to administer myself. I honestly noticed no side effects after taking it, other than not thinking about food as much and wanting to eat a little less. I did push the boundaries on the third evening after taking it, and I did have bad nausea, I actually vomited and felt generally ill for about 16 hours (not bad enough to not work though). I pushed the boundaries by overeating air-fried chicken wings (no sauce) that were a bit more greasy/oily than normal. Those really set me off, and I realized that I: 1. can no longer eat any type of greasy food and 2. cannot eat too much. As long as I stick to my normal healthy, low-carb diet, I feel just fine (so far)."

9 / 10
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  • Bon...
  • Taken for less than 1 month
  • June 10, 2023

For Weight Loss (Obesity/Overweight) "Honestly, I have never been so sick in my life. 1st and only dose of Wegovy made me so incredibly sick. I have been in the hospital twice for excessive dry heaving. There is no stopping the symptoms. I had short-term relief with IV sedatives and anti-nausea medications. Still a week later, now at home throwing green bile. I will never recommend it to anyone."

1 / 10
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  • CAD...
  • Taken for 1 to 6 months
  • December 13, 2020

For Type 2 Diabetes "I’m prediabetic, HbA1c 5.7. And I’ve been struggling to lose weight for 20 years. I have an excellent diet, but I eat too much. I’m hungry all the time. I started Rybelsus (paying out of pocket - Ouch) to see if it’s worth hassling my insurance company. On 3 mg, I felt nothing - no nausea, but experienced loose stools. When I went to 7 mg, I felt nausea for 1 hour after taking the pill and decreased appetite the rest of the day. I am easily staying on my 1400-1500 calorie diet, which has never been easy for me in the past. At 1 month of 7 mg, I’ve lost 8 pounds (255 to 247) and feel very encouraged. The science behind this medicine is inspiring."

10 / 10
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  • Kir...
  • Taken for 1 to 6 months
  • February 3, 2022

For Weight Loss (Obesity/Overweight) "I'm on 2.4 now. Started yesterday and still have pretty bad nausea. It's the worst it's been. Before, it was quite negligible or non-existent. So far, I've lost 21 lbs in 4 months. I was 216, now 195 and I am 5'4'. I still have a long way to go. I started working out and started a vegan diet in January to improve my cholesterol. I know it's tough. I have read so much about it and my expectations were high, like all I need to do is take this injection and the weight will fall off! This will fix all of my problems! I'll find true happiness! But...that's not the case for most people, including me. My provider said that some of her patients have seen no results. She said a 20 lb weight loss is right on track for me and more sustainable than the amazing results some are seeing (though everyone is different). Remember: we are more than our weight. And there is no one answer. If you are taking this and it's not working, it's not you."

8 / 10
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  • Ann...
  • Taken for 6 months to 1 year
  • September 9, 2019

For Type 2 Diabetes "Have been on Ozempic for 10 months. The first 3 months were very difficult with strong side effects. Mainly constant, but low level, nausea, occasional vomiting, and diarrhea (especially two days after the injection). However around month 3 the nausea and diarrhea subsided greatly and my appetite returned. I had lost weight very quickly (42 lbs in 3 months due to not really eating much). Had to take supplements for a while but am now eating well. The rapid weight loss led to telogen effluvium, a temporary hair loss condition. (I shed A LOT but never showed any baldness or anything). Currently, my weight is still down (I was taken off my blood pressure medication!), my blood counts are perfect, my hair is getting thick, and I eat normally. I now experience virtually no side effects. Really, really, glad I stuck out the side effects at the beginning."

7 / 10
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  • siv...
  • Taken for 1 to 6 months
  • December 10, 2020

For Type 2 Diabetes "My doctor put me on Rybelsus as I had high blood sugar. I had too much difficulty taking the 3 mg with nausea, diarrhea, and headache. I planned to quit, but I read the reviews here. I somehow managed my symptoms and tried harder. My doctor then increased the dosage to 7 mg. Rybelsus was able to bring my blood sugar levels from 10.6 to 5.6, almost normal levels in a period of 3 months. If anyone is planning to quit, please persevere, and the results are amazing. It practically stops your cravings for food and helps you stabilize. Another miracle was that I was finally able to quit coffee in the morning as I get migraines without it. Compared to the nausea, diarrhea, and the churning of the stomach, migraine wasn't a big deal, and I finally went without taking coffee. This is really a miracle drug for diabetes. Thank you."

10 / 10
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  • Fat...
  • Taken for 1 to 6 months
  • March 27, 2021

For Type 2 Diabetes "My A1c has been hovering around 7, and my weight was creeping up, so my doc suggested this. I started on the 3, and the nausea and projectile vomiting were rough... indeed, I didn’t think I could handle it. Then I discovered if I take it when I wake in the small hours to pee, if I took it then, I had almost no problems. I’m now up to the 15mg dose, and so far I’ve gone from around 255lb to about 220lb and falling. Two whole jean sizes... haven’t done new labs yet... but the weight loss is remarkable... it’s also quite weird to essentially almost never feel hungry anymore."

8 / 10
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  • KCF...
  • Taken for 1 to 6 months
  • March 25, 2025

For Chronic Kidney Disease "I have been on Ozempic for the past 1 1/2 months. Gradually increased from 0.25 mg for 4 weeks, then 0.5 mg since then. After reading other reviews, the best tip I found was injecting into my thigh instead of the abdomen. Mild nausea, backache, and constipation the first 2 weeks, and nothing now but the feeling of fullness soon after eating, about 75% as much as usual. I have less interest in sugary or fried foods and have lost 12 pounds, about 2 pounds a week. At 74, my Type 2 diabetes is diet-controlled with good A1C's, so my primary use is for weight loss and preserving kidney functioning. The tiny 27 gauge needle is painless, just wish I had discovered Ozempic sooner!"

10 / 10
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  • Dun...
  • Taken for 1 to 2 years
  • January 9, 2024

For Weight Loss (Obesity/Overweight) "I started off taking Ozempic then switched over to Wegovy. I only experienced mild side effects such as nausea and headaches in the beginning of starting these meds. This medication worked for me and helped me lose over 60 lbs. In the past, I have tried numerous diets, supplements, bariatric surgery, and programs to help me lose weight and all failed. This is the only medication that truly worked for me and I'm so glad that I was able to tolerate it. Life-changing experience for me."

10 / 10
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  • JMH...
  • Taken for 1 to 2 years
  • March 22, 2024

For Weight Loss (Obesity/Overweight) "I have been on Wegovy for a year and 3 months and have lost 100 lbs. (started at 289 & 5'7"). I do deal with nausea, but it is controllable with Zofran so I keep that on me at all times. You are in control of how you feel by what you eat and the amount of water that you drink. Protein is key! I have dealt with a B12 deficiency since being on this med as well as hair loss. I deal with chronic pain so working out has never been easy for me. Wegovy has been a game changer and completely changed my life. I went from a 2X to a L in clothing and feel the best that I've ever felt despite the nausea."

9 / 10
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  • Mel...
  • Taken for 6 months to 1 year
  • February 25, 2021

For Cardiovascular Risk Reduction "I have been on Ozempic for weight loss for 10 months and I have lost 66 pounds!! This drug has been amazing. At first, I had a few side effects which included nausea and constipation but they did resolve. I noticed almost immediately how much better I felt on this drug. Not only was my appetite significantly decreased, I felt better overall, sort of like my metabolism was more even and my body utilized what I ate more efficiently. I lost my work insurance in November and also lost the coverage for Ozempic. This is the only downfall. I do have private insurance through HealthPartners but not one cent is covered by them. The price per month is around $800. With results this good, all insurance companies should be covering the cost 100% because it will save them millions, billions, even trillions possibly in the future. If they were smart, they would get behind this drug."

10 / 10
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  • Dan...
  • Taken for 1 to 6 months
  • March 24, 2019

For Type 2 Diabetes "I’ve been on this med for 7 weeks. I’ve lost 25 lbs and my daily blood sugars range from 60 - 90. I use it along with 500 mg Metformin. The first couple of weeks were hard with nausea and stomach cramps. I also had the headaches that others have mentioned in the first couple of days. In week 3, I increased from 0.25 to 0.50. Then came the diarrhea. It wasn't too bad, I was just happy that I could go. I’m now taking 1.0 and experiencing sulfuric burping. Ugh! After doing some research on home remedies to help with the burping, I’m trying a spoon of apple cider vinegar. If you can make it through the first few weeks and you can be somewhat disciplined, you will notice a huge difference in how you feel. In my opinion, the side effects are manageable when I compare the weight gain while taking Insulin. BTW - I’m not severely obese. Prior to being on this drug, my weight was 205, and I’m 5’9 and 47 years old. I hope this is helpful to someone."

9 / 10
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  • HPa...
  • Taken for 1 to 6 months
  • June 11, 2020

For Cardiovascular Risk Reduction "In June of 2019, I was prescribed Ozempic for the first time for weight loss. I was given a sample in the office, and my prescription was sent to the pharmacy. My doctor was super optimistic, and I had seen drastic results in someone else I knew, but had been warned about the nausea. I am insulin resistant, have PCOS, and had gastric sleeve surgery in 2008. At the time I started the first 0.25 dose, I weighed 191.2 lbs. On the single pen, I did 4 weeks of 0.25 and 2 weeks of 0.5 doses. At the end of the 6th week, I weighed 173.8 lbs. That’s 17.4 lbs in 6 weeks! Of course, then insurance denied covering it moving forward, and I was unable to continue. But after a year, new bloodwork panels and some adjustments, somehow it has been approved, so I have started it again today! Hopeful for the same results! I had been taking a topamax/phentermine combo and was really disliking the pens, needle side effects, and the severe change in my tastebuds that it caused."

2 / 10
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  • Won...
  • Taken for 6 months to 1 year
  • September 9, 2022

For Type 2 Diabetes "Was placed on this medication to help with PCOS-caused insulin resistance and obesity. The first two months were a bit uncomfortable - I was nauseated a lot and had bouts of constipation and diarrhea. Fortunately, immediately starting it, my sugar cravings disappeared. I think I had a rough couple of months because of my old eating habits since this medicine slows how fast your stomach empties. As I developed better eating habits, this has gone away completely. I’ve been on this for almost a year now and have lost almost 60 lbs. I’m about 5 lbs away from being a normal weight and I’m barely making any effort at this point; the weight is just coming off. I feel the healthiest I’ve felt in over a decade and have been seeing my PCOS symptoms reduce as the weight comes off. This medicine was a miracle for me. I’ve struggled for a decade trying to get my weight under control. Once the insulin resistance was resolved, it literally fell off."

10 / 10
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  • Kri...
  • Taken for less than 1 month
  • July 2, 2023

For Weight Loss (Obesity/Overweight) "This drug affects everyone differently, but for me, the side effects were too bad, and I had to stop after 2 weeks. It totally worked by killing my appetite and making me feel full, and after the first week, there were days I didn't even want to eat at all. I lost about 8 pounds in two weeks, which is great. However, during the 2nd week, I got the worst upset stomach of my life and almost went to the ER. I had intense diarrhea for an entire day, along with nausea, the chills, a swollen stomach, and then sweating. I had to take a sick day from work because I was also dizzy, and my heart was racing. It finally subsided about a day and a half, but it scared me so badly that I stopped taking the drug. Now I understand why it has a black box warning. I'm happy for the people who can use this without bad side effects. For me, I have a young child and demanding job. I can't go around with symptoms of food poisoning and try to act like I’m ok."

4 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.