Prometrium and Sore Breasts: What Users Say

• Anonymous
• Taken for less than 1 month
• October 23, 2020

For Uterine Bleeding "I am on 200 mg Prometrium due to uterus bleeding and enlarged uterus wall. Other than the bleeding, I had no post-menopause issues (I am 57 with high estrogen levels). After 2 days of taking the medication, bleeding stopped - great! After a few more days, I started gaining weight, breast tenderness, breast enlarging, very strange dreams every night, very tired during the day although I sleep at least 8 hours now, and bad headaches. Too many side effects for me. I went to my naturopathic doctor to do detailed hormone tests. Result = extremely high progesterone level. Make sure you get your hormones tested before taking the medication!"

• boo...
• November 22, 2016

For Progesterone Insufficiency "I was diagnosed with hyperplasia. I was experiencing very heavy, clotty periods for YEARS. I thought this was normal until I had a month-long period. This pill is heaven-sent. I have not had a period for about 8 months, have lost a ton of weight, have more energy than I have had in years, and I would say the only side effect is tender breasts. I cannot guarantee this result for everyone, but clearly I was not producing my own progesterone."

• Mia...
• Taken for less than 1 month
• June 18, 2021

For Progesterone Insufficiency "I am 46. I am estrogen dominant and have low progesterone. I also have PCOS. I take 100 mg after menstrual bleeding, 200 mg upon ovulation, and none when bleeding starts. My periods were abnormal (cycle 25-36). I take it by mouth at night and go straight to bed as it makes me extremely drowsy. If I try to stay up, I have lucid dreams. Some tiny stomach cramps but not bad. Breast tenderness has drastically decreased. Some left shoulder pain. Not sure if that has anything to do with the medication. Since starting break-through spotting during ovulation and a short window between ovulation and period. Cycle is currently now at 20 days. I have read this can happen but can’t find a lot of reviews on it. Not sure if that is normal and will be following up. Facial hair growth appears to have decreased."

• Ste...
• Taken for 1 to 6 months
• August 2, 2020

For Perimenopausal Symptoms "I started taking 200 mg day 14-28 of my cycle. My doctor had me combine it with a progesterone cream. My breasts became bigger and much more tender. I began steadily gaining weight, up 7 lbs now. I am going to go off the Prometrium and go back to the cream only and see if the sore breasts and weight gain subside. The cream worked well for me in the past, not sure why my doctor felt I needed both the cream and the pill. I do feel progesterone is wonderful for reducing mood swings and food cravings. That issue is all but abolished when I'm on the progesterones, I just am obviously not a fan of the weight gain. So if the goal of the medicine is to increase progesterone levels and decrease mood swings, it is effective."

• Ste...
• Taken for 1 to 6 months
• August 2, 2020

For Perimenopausal Symptoms "I started taking 200 mg day 14-28 of my cycle. My doctor had me combine it with a progesterone cream. My breasts became bigger and much more tender. I began steadily gaining weight, up 7 lbs now. I am going to go off the Prometrium and go back to the cream only and see if the sore breasts and weight gain subside. The cream worked well for me in the past, not sure why my doctor felt I needed both the cream and the pill. I do feel progesterone is wonderful for reducing mood swings and food cravings. That issue is all but abolished when I'm on the progesterones, I just am obviously not a fan of the weight gain. So if the goal of the medicine is to increase progesterone levels and decrease mood swings, it is effective."

• ACE...
• November 13, 2008

For Uterine Bleeding "My doctor is having me take this medication because I have excessive bleeding. So far, the bleeding has stopped, but I'm on day 10, and the side effects are kicking in. I have breast tenderness, stomach cramps, and it makes me very tired. Overall, so far it has done what it needs to do. I go off of it in 2 days, I'm hoping that my body will regulate."

• Anonymous
• Taken for less than 1 month
• August 25, 2012

For Amenorrhea "I am currently taking this medication for a missed cycle. I was told to take it at night due to the drowsiness it may cause. So far, I have not noticed much of a problem with that. I have been on the pill for 5 days, and the side effects are almost unbearable. I have breast tenderness, but also the muscles around my chest/back area are aching to the point of being painful. I called my doctor about this side effect and was told that the medication has not been known to cause achiness. After reading this website, I see it is very possible. I have had some dizziness, sweating, and irritability as well. Either way, the medication seems to be helping, but I really cannot wait to quit it!"

• swh...
• Taken for less than 1 month
• October 23, 2012

For Progesterone Insufficiency "I am 49 and have been on this medication for one cycle. The side effects have not been as bad as I had anticipated. I had a few mild headaches, a bit of bloating, tender breasts, and a mild acne breakout, and was a bit tired a few days. I am taking it for a proliferative endometrium, and after 4 days being off the medicine, I am getting a period, so it seems to be working as planned. I am taking 200 mg."