Prometrium and Tiredness: What Users Say

• Anonymous
• March 20, 2010

For Progesterone Insufficiency "I'm pregnant and my lab work came back indicating I have a low progesterone level. My doctor prescribed Prometrium and initially I took the medication in the daytime, but then found that it makes me extremely tired. I decided to start taking the medicine at bedtime then started having very bizarre dreams only when I take the medication at bedtime. I informed my doctor, but he dismissed the side effect as not being related. I'm positive the side effect is from the medication. I hope this comment lets other women who experience this side effect know that you are not alone. Just because it's not a listed side effect doesn't mean it can't happen."

• Anonymous
• Taken for less than 1 month
• October 23, 2020

For Uterine Bleeding "I am on 200 mg Prometrium due to uterus bleeding and enlarged uterus wall. Other than the bleeding, I had no post-menopause issues (I am 57 with high estrogen levels). After 2 days of taking the medication, bleeding stopped - great! After a few more days, I started gaining weight, breast tenderness, breast enlarging, very strange dreams every night, very tired during the day although I sleep at least 8 hours now, and bad headaches. Too many side effects for me. I went to my naturopathic doctor to do detailed hormone tests. Result = extremely high progesterone level. Make sure you get your hormones tested before taking the medication!"

• Jac...
• Taken for 1 to 6 months
• May 8, 2022

For Progesterone Insufficiency "Side effects not worth the gain. Had been using bioidentical progesterone (via a troche) for the last 12 years with no side effects, until my doctor retired, leaving a 5-month wait for a new bio-id doctor willing to take on new patients. In the interim, I moved to an online service that prescribed Prometrium. It's awful. I wake each morning feeling like I've been hit by a bus: deeply tired, no energy, no libido, and a consistently flat mood bordering on mild depression with swings of moodiness. The worst symptom, though, is the extreme increase in asthma and struggle to breathe even after the lightest exertion (something I've not experienced before and is equally frightening for my family). The service advised me to double the estrogel, hoping to balance it, then to cut the Prometrium dosage in half, but that's causing noticeable weight gain and the side effects lessen on the day after I don't take it, but not significantly. It's been 3 months of struggle. This drug clearly doesn't suit me."

• Jac...
• Taken for 1 to 6 months
• May 8, 2022

For Progesterone Insufficiency "Side effects not worth the gain. Had been using bioidentical progesterone (via a troche) for the last 12 years with no side effects, until my doctor retired, leaving a 5-month wait for a new bio-id doctor willing to take on new patients. In the interim, I moved to an online service that prescribed Prometrium. It's awful. I wake each morning feeling like I've been hit by a bus: deeply tired, no energy, no libido, and a consistently flat mood bordering on mild depression with swings of moodiness. The worst symptom, though, is the extreme increase in asthma and struggle to breathe even after the lightest exertion (something I've not experienced before and is equally frightening for my family). The service advised me to double the estrogel, hoping to balance it, then to cut the Prometrium dosage in half, but that's causing noticeable weight gain and the side effects lessen on the day after I don't take it, but not significantly. It's been 3 months of struggle. This drug clearly doesn't suit me."

• chi...
• March 10, 2010

For Amenorrhea "This drug is effective at inducing a period, but it has awful side effects. Basically, you will feel pregnant-tired, dizzy, hungry for junk food, and bloated. My breasts grew half a size within 3 days of taking. Then the rest of me caught up and I gained 5 lbs in the 10-day time frame that I took this drug. But it did do what it was supposed to do, so I can't totally complain."

• ACE...
• November 13, 2008

For Uterine Bleeding "My doctor is having me take this medication because I have excessive bleeding. So far, the bleeding has stopped, but I'm on day 10, and the side effects are kicking in. I have breast tenderness, stomach cramps, and it makes me very tired. Overall, so far it has done what it needs to do. I go off of it in 2 days, I'm hoping that my body will regulate."

• swh...
• Taken for less than 1 month
• October 23, 2012

For Progesterone Insufficiency "I am 49 and have been on this medication for one cycle. The side effects have not been as bad as I had anticipated. I had a few mild headaches, a bit of bloating, tender breasts, and a mild acne breakout, and was a bit tired a few days. I am taking it for a proliferative endometrium, and after 4 days being off the medicine, I am getting a period, so it seems to be working as planned. I am taking 200 mg."

• joj...
• Taken for 1 to 6 months
• April 7, 2023

"Two months into taking this med, I have found it's making me feel ill. Dizziness, shortness of breath, lethargy. I've had test after test. Then realized this all happened after starting this med."