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User Reviews for Progesterone to treat Progesterone Insufficiency

Also known as: Prometrium, Crinone, Endometrin, Gestone, Cyclogest, First Progesterone MC10, Milprosa First Progesterone MC5

Progesterone has an average rating of 7.3 out of 10 from a total of 23 ratings for the treatment of Progesterone Insufficiency. 65% of reviewers reported a positive effect, while 13% reported a negative effect.

Progesterone Rating Summary

7.3/10 average rating

23 ratings from 24 user reviews.

Compare all 5 medications used in the treatment of Progesterone Insufficiency.

10
22%
9
13%
8
30%
7
9%
6
9%
5
0%
4
4%
3
0%
2
4%
1
9%

Reviews for Progesterone

Stat5150 · Taken for 1 to 6 months July 21, 2019

Prometrium (progesterone): “I was given prometrium 100mg vaginal inserts 14 days out of the month along with estradiol patch 1mg for post menopausal symptoms. Prior to taking the prometrium, I was sleeping poorly and had stubborn weight around the belly I couldn't get rid of. After menopause, my figure changed and I gained a total of 10 lbs. Well...miraculously in a month on these, I lost 7 of those pounds! I am sleeping really well. Almost too much but maybe I needed it. My post menopause pants are getting too loose now and I think I'll have to unpack my high-rise jeans. Yay for prometrium!”

8 / 10
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Just an FYI. · Taken for 1 to 6 months September 5, 2016

Prometrium (progesterone): “I've been taking Prometrium for about 4 months now, & for the most part have no side effects. It works like its suppose to and keeps my progesterone to where it needs to be. However, just an FYI you should always take it before bed with food & I mean lights out in bed to sleep not watching TV or playing on your phone/tablet. If you take Prometrium & not go to bed it will cause a euphoric (high) feeling which may be unsettling to some people & may cause panic, because it does feel really weird.”

9 / 10
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skrumm March 4, 2009

Prometrium (progesterone): “I'm 48, and found that this nicely balanced the issues I'm having with estrogen dominance. I've had no side effects that I can tell, but a real clearing up of the fuzzy brain, night sweats, and trouble sleeping. I love it!”

9 / 10
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MiaR · Taken for less than 1 month June 18, 2021

Prometrium (progesterone): “I am 46. I am estrogen dominant and have low progesterone. I also have PCOS. I take 100 mg after menstrual bleeding, 200 mg upon ovulation, and none when bleeding starts. My periods were abnormal (cycle 25-36). I take it by mouth at night and go straight to bed as it makes me extremely drowsy. If I try to stay up, I have lucid dreams. Some tiny stomach cramps but not bad. Breast tenderness has drastically decreased. Some left shoulder pain. Not sure if that has anything to do with the medication. Since starting break thru spotting during ovulation and short window between ovulation and period. Cycle is currently now at 20 days. I have read this can happen but can’t find a lot of reviews on it. Not sure if that is normal and will be following up. Facial hair growth appears to have decreased.”

9 / 10
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Anonymous March 20, 2010

Prometrium (progesterone): “I'm pregnant and my lab work came back indicating I have a low progesterone level. My doctor prescribed Prometrium and initially I took the medication in the daytime, but then found that it makes me extremely tired. I decided to start taking the medicine at bedtime then started having very bizarre dreams only when I take the medication at bedtime. I informed my doctor,but he dismissed the side effect as not being related. I'm positive the side effect is from the medication. I hope this comment let other women who experience this side effect know that you are not alone. Just because it's not a listed side effect doesn't mean it can't happen.”

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boomer1171 November 22, 2016

Prometrium (progesterone): “I was diagnosed with hyperplasia. I was experiencing very heavy, clotty periods for YEARS. I thought this was normal until I had a month long period. This pill is heaven sent. I have not had a period for about 8 months, have lost a tone of weight, have more energy than I have had in years and I would say the only side effect is tender breasts. I cannot guarantee this result for everyone but clearly I was no producing my own progesterone.”

10 / 10
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Jules · Taken for 1 to 6 months November 24, 2019

“I’ve had a complete hysterectomy & am doing bio identical HRT therapy pellets on October 16th. Unfortunately progesterone has to be taken in pill form. I’m on 100mg at night. I looked at my RX just now & it’s the generic form from the manufacturer Akron. I’ve been having severe stomach cramps, back & rib pain, sneezing, itching and the crazy vivid dreams. I also am having anxiety to the point I can’t form words sometimes. I’m sincerely hoping that it’s just a matter of switching manufactures of the medication, because I absolutely need progesterone. Even with all these side effects, it is finally helping get rid of my hot flashes, mood swings & most importantly I’m getting my libido back. Not to mention it’s helping to pull me up ever so much out of this major depression I’ve been in for years. I go back to my doctor in a week to get bloodwork for my hormone level check, so he can do some fine tuning. Will update”

7 / 10
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Lena July 16, 2019

“On June 30, 2019 the pharmacy filled my prescription with a new generic drug from the manufacturer Akorn, for micronized progesterone 100 mg capsules, I take 300 mg each night. The generic for Prometrium from Akorn manufacturer-generic micronized progesterone, I started itching, now I am itching head to toe, also, I started having headaches and dizziness. I started having strange vivid dreams, not sleeping well, increased hot flashes. I have been taking Prometrium for many years, including other generics without any problems. I decided to stop taking the Akorn manufacturer generic micronized progesterone 100 mg capsules, and request a new prescription of Prometrium. The FDA wrote two warning letters to Akorn in 02/2018 and 06/2019, at the same plants where the medication was made. It may be contaminated with unknown foreign substances. My co-pay after insurance for a 90 day supply was $241.24 -for quantity of 270 capsules, 100 mg each. Very expensive for a generic that harmed me!”

1 / 10
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Shell99 · Taken for less than 1 month October 17, 2016

“Hey everyone, told you I'd be back. Lol So I'm still on the AK 100mg. pill. I have lost over 3 pounds. I haven't changed anything since before taking this medication. In fact the only thing it changed is my mood, and stress levels, an of course my hormonal issue. I do have a tiny list of effects it's had on me so far. Ok so, my voice before was deeper an more loud, angry so to speak.(Which was because of too much testosterone in my system.) So my voice started to change 3 days after starting this pill. It gave me a slight sore throat at first. Then my voice would cut out, or crack. So embarrassing...but now I have a softer tone. My depression is much less, I'm much happier now an positive. Acne is gone now too. Btw I'm 38. An progesterone works.”

10 / 10
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Laulee June 27, 2019

“I started generic Prometrium for 10 days (for Premature menopause) then stopped because I broke out with itchy red bumps on my arms & legs. And, I still got hot flashes. When I stopped taking the progesterone (200mg at night) I started getting foggy brain again and terrible face aches and headaches. I restarted the generic Prometrium after a 5 day hiatus & after the red itchy bumps dried up. Now that I take the 200mg again no more head or face aches, and mild hot flashes finally disappeared. However, I continue to have vivid exhausting dreams every night that I take this. My sleep is NOT deep or restful. It is night after night of lucid, unwanted crazy dreams. This is an unreported side effect- I read other women experienced this, too. Also I get tiny somewhat itchy bumps under the skin on both of my hands. I wonder if the brand name Prometrium would have these bad effects on me as well...”

6 / 10
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swhitico81 · Taken for less than 1 month October 23, 2012

Prometrium (progesterone): “I am 49 and have been on this medication for one cycle. The side effects have not been as bad as I had anticipated. I had a few mild headaches, and bit of bloating, tender breasts and a mild acne breakout, and was a bit tired a few days. I am taking it for a proliferative endometrium and after 4 days being off the medicine, I am getting a period, so it seems to be working as planned. I am taking 200 mg.”

8 / 10
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Shell99 October 7, 2016

“I'm on AK pill. My doctor said my weight problems an acne are from having no progesterone to regulate my hormones. An that it made my testosterone too high, which makes it hard to lose any weight. Took last night. Slept great. No bloat, an high energy. I'm happy so far. Can't say I have any bad side effects. I'll check back if I get any negatives.”

8 / 10
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Anonymous September 25, 2009

“I am taking progesterone suppositories to help sustain my pregnancy after a miscarriage due to insufficient progesterone levels. I began taking it at 4 wks pregnant, and am now 9 weeks along. My side effects have included drowsiness, cramping, bloating and upset stomach. A rather unfortunate side effects has also been vaginal itching and dryness that leads to major discomfort for the hour or two after I have inserted the medication. These are little issues that feel big, but in the grand scheme of things, if this medication helps me to have a healthy pregnany and baby, it will be well worth it.”

8 / 10
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PL · Taken for 5 to 10 years November 27, 2020

“I have a progesterone insufficiency and one of its main symptoms is insomnia. Prometrium is too expensive in the US and the doc switched me to the Bionpharma generic. Unfortunately this is not natural progesterone but rather a progestin. After struggling with insomnia for weeks, I had to order actual progesterone from a compounding pharmacy. Now I am finally back to sleeping 8 hrs per night. My understanding is that US companies no longer use natural progesterone in their generics, so compounding pharmacies are the only viable alternative.”

10 / 10
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nightOwl March 18, 2019

“Just four times a year? I'll take it. I need this Rx because I am on an estrogen patch for severe menopause symptoms. My dose is intra-vaginally, 200 mg, every other night for 12 nights, every 3 months - so 4 times per year. I never forget it because I begin my regimen at the start of each season. This method of progesterone by far right easiest method to tolerate for me. I won't use these hormones forever, but for right now, they help. The first few days, I get mild PMS symptoms - to be expected - then usually begin menstruating, which means it did its job. The PMS rises and falls with stress levels and other issues. I manage it by doubling my exercise routine, adding meditation; - high stress levels drive many PMS symptoms. I also switched to a Mediterranean diet a few years ago. I strongly recommend these things as they have a proven record of reducing PMS symptoms.”

8 / 10
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Anonymous October 19, 2011

Prometrium (progesterone): “I am on 100mg dose, days 14-28 of my period or the first 12 weeks of pregnancy. The first month was great, I felt level, the only side effects felt were extreme sugar cravings and vivid, bizarre dreams. However, in month two, no cravings, extreme mood swings and ranging from a need for a lot of sleep, not wanting to get out of bed to anxiety and very little sleep. No pregnancy yet.”

7 / 10
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Snotori · Taken for less than 1 month June 10, 2012

“All day dizziness and general blah feeling. Sleep majorly disrupted and when I get it it doesn't do anything to help with the tiredness I already have. Nails grew weak and thin. Also had some numbness in places which went away when I stopped the pill.”

2 / 10
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Maureen2 April 26, 2016

“The first two years on 100 mg were ok with a very rough 3 month adjustment period of feeling emotionally and physically completely wacked out. After two years I started feeling menopausal symtoms of brain fog again so started taking 200 mg. This is my second month, emotional roller coaster angry outbursts, racing heartbeat, no sleep! I am giving it another month to see if things Will get to normal like before. Maybe I have to go through this every several years, part of getting older.”

6 / 10
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Amber712 · Taken for less than 1 month September 30, 2012

“I am using this in my FET cycle for IVF. I am 4 weeks, 4 days pregnant. I was taking 2 vaginal inserts (100mg) each per day but after blood tests came back showing a very low Progesterone level, my Dr is having me take an additional 600 mg per day in pill form (200 mg, 3x per day). My Dr warned me that I would be very tired and possibly dizzy. I have been on the pills for 3 days now and have noticed that my breast are very tender and swollen which they weren't before and it does make me a little drowsy but not bad, It's manageable. I go back on Tuesday to check my levels.”

8 / 10
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Baby2017 · Taken for less than 1 month January 27, 2017

“I was prescribed progesterone in early pregnancy due to insufficiency. I switched pharmacies and this p-2 progesterone pill was a new brand that I was switched to. Two hours after taking the first pill (vaginally, as directed) I had spotting. This spotting continued for three days while I was on this pill. One day I didn't take it until the late afternoon and all morning had no bleeding. Then two hours after taking the pill I started bleeding again. I was far enough along in my pregnancy that when I brought this up to my doctor he said that I could safely stop taking it. Ever since I stopped taking this pill, the bleeding had since stopped too! I would not recommend this brand of progesterone.”

1 / 10
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Anonymous December 31, 2008

Prometrium (progesterone): “I experienced a few mild side effects - mainly mild nausea and irritability. Well worth the improvement in my overall health.”

8 / 10
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Nic · Taken for 1 to 6 months November 8, 2018

Crinone (progesterone): “I used it for IVF/Frozen Embryo Transfer. I’m due with our baby any day now, it was super easy and convenient to use. I’d much rather do this than a intra-muscular shot into the butt every day.”

10 / 10
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Jules · Taken for 1 to 2 years September 11, 2019

“I get freaky and can't remember what happened the next morning!”

10 / 10
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Anonymous · Taken for less than 1 month August 24, 2015

Crinone (progesterone): “After a few days of use I had such horrible itching it prevented me from sleeping. The itching took about a week after discontinued use to subside.”

4 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.