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Methamphetamine and Irritability: What Users Say

Brand names: Desoxyn, Desoxyn Gradumet

Irritability: mentioned by 6 users (7.8%)

Based on user experiences from 77 Methamphetamine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 16.9%
anger 7.8%
irritability 7.8%
depression 6.5%
loss of appetite 6.5%
headaches 5.2%
increased heart rate 5.2%
euphoria 3.9%
insomnia 3.9%

Reviews for Methamphetamine

Commonly mentioned side effects
  • bra...
  • November 9, 2015

Methamphetamine for ADHD "The medical establishment should be ashamed! I have struggled all my life with side effects from the 'acceptable' ADD medications. They gave me anxiety and a crash that made me irritable to boot! I have none of those side effects now, and people have noticed a very positive change in me. I am much more successful at my job, my anxiety is much lower, and my wife has noticed my nightly irritability is completely gone. I now feel like a complete person! Why wasn't I prescribed this first? How much of my life have I lost? What could I have accomplished? I'm glad I didn't know this was actually methamphetamine when I was prescribed it, or I would have said NO WAY. How the media portrays it and the actual effects on me are miles apart."

10 / 10
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276 Report
  • Jus...
  • January 14, 2019

Methamphetamine for ADHD "With this review, I want to cover two things: 1. Effectiveness of the medication itself. First, I have to say, after dealing with depression and ADD for most of my life, and having tried literally every conventional antidepressant and ADD medication, I can honestly and without hesitation say that Desoxyn is the absolute best medication I've ever used to treat my ADD. Ritalin worked for a brief period of time, then the side effects would dominate the efficacy with concentration. I generally felt like I had consumed too much coffee when I took Ritalin. Dexedrine made me feel hyper and edgy. Adderall was even worse, with Peripheral Nervous System stimulation that made my body sweat, my mind dart back and forth, and my stomach turn in knots. It was a miserable experience. I wanted something different. I met with a new provider, who was very open-minded when it came to medication and alternative therapies..."

9 / 10
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133 Report
  • MPG...
  • Taken for 6 months to 1 year
  • December 12, 2017

Methamphetamine for ADHD "I have tried Adderall, Dexedrine, Ritalin, and other formulations... all of which had issues. Adderall was the worst, or most notable at least, due to the extreme anger, frustration, tendency towards violence, physical tension, and horrible comedowns. I cannot tolerate more than 20-30mg of this medication, period. Ritalin, on the other hand, was very good for some tasks like school work and math problems. However, it dulled my emotions and made me feel less 'like me'? Desoxyn feels smooth, positive, and had the least negative physical side effects. The focus was not as intense as other amphetamines, but I felt that it allowed me to have more control over my emotions than any other ADHD medication... while feeling sober."

10 / 10
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112 Report

Frequently asked questions

  • 133...
  • Taken for 1 to 2 years
  • February 27, 2020

Methamphetamine "I have idiopathic hypersomnia and no stimulant worked for me prior to Desoxyn. I haven’t had to increase my dose (40 mg/day), and for the first time I’m not on an off-label dose. I feel calmer on it, it boosts my mood, I have more of an appetite on it (compared to others), and it keeps me awake! The only downside to this medication is how difficult it can be to obtain. My insurance changed, and it was a battle to get 40 mg approved, and it cost more. I’m scared to ever switch again because it’s a constant battle when it comes to insurance. I’ve had to go on many a medical treasure hunt to get it due to the name’s bad reputation. I can start/stop it no problem. I’ve never felt high on it or craved it. It doesn’t make me angry, super irritable, or depressed. It’s by far the best I’ve tried for IH!"

10 / 10
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58 Report
  • Tru...
  • Taken for 10 years or more
  • March 20, 2023

For ADHD "I too am like most of the people with ADHD who commented here. After trying all the others that are typically prescribed for this disorder and had unwanted 'direct effects' like highs and lows, turning stomach, poor appetite, along with poor sleep patterns. Feeling like an empty shell, agitated, moody, and just pissed off for all those reasons. Like many others with ADHD, in this world I'm sure. When I was prescribed this medication, I instantly felt like a human being. A true member of society for once in my life. I too don't understand why methamphetamine, even when produced legitimately and legally in a real sterile lab, by real properly educated scientists using only the proper ingredients, unlike the stuff sold on the streets, could still be so ridiculed and looked down upon so negatively. I really don't understand!"

10 / 10
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10 Report
  • Naa...
  • May 3, 2019

"After having tried literally every stimulant for narcolepsy, methamphetamine is the only one that doesn't make me feel like complete garbage. For a long time, I was on 120 mg of Adderall, and it made me extremely angry and depressed. I later tried multiple ER stimulants, and they never kept me awake. This is the only stimulant that I don't feel terrible on. The first day I took it, it made my teeth hurt really bad, but it's been getting better, and I wear a nightguard for my teeth just in case. It's not perfect, but it gets the job done, and it's the only one that doesn't make me want to pick at my skin. Methamphetamine doesn't give me the urge to pick at anything. I still get slightly agitated towards the evening, but nothing compared to other stimulants. It keeps me calm and awake (for the most part). I'm currently on 40 mg/day - I take 20 mg when I wake up and 20 mg later on in the day, and it's been doing a good job of keeping me alert and awake."

8 / 10
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10 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.