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Methamphetamine Side Effects

Medically reviewed by Last updated on May 18, 2023.

Applies to methamphetamine: oral tablet.


Oral route (Tablet)

Warning: Abuse, Misuse, and AddictionMethamphetamines have a high potential for abuse and misuse, which can lead to the development of a substance use disorder, including addiction. Misuse and abuse of CNS stimulants, including methamphetamine, can result in overdose and death, and this risk is increased with higher doses or unapproved methods of administration, such as snorting or injection. Before prescribing methamphetamine, assess each patient’s risk for abuse, misuse, and addiction. Educate patients and their families about these risks, proper storage of the drug, and proper disposal of any unused drug. Throughout methamphetamine treatment, reassess each patient’s risk of abuse, misuse, and addiction and frequently monitor for signs and symptoms of abuse, misuse, and addiction.

Serious side effects of Methamphetamine

Along with its needed effects, methamphetamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methamphetamine:


Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking methamphetamine:

Symptoms of overdose

Other side effects of Methamphetamine

Some side effects of methamphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to methamphetamine: oral tablet, oral tablet extended release.


Fatal cardiorespiratory arrest has been reported, mostly in the context of abuse/misuse.

Frequency not reported: Elevated blood pressure, tachycardia, palpitation, fatal cardiorespiratory arrest

Postmarketing reports: Peripheral vasculopathy


Frequency not reported: Urticaria, alopecia


Frequency not reported: Diarrhea, constipation, dry mouth, intestinal ischemia, other gastrointestinal disturbances


Frequency not reported: Impotence, frequent/prolonged erections


Frequency not reported: Rhabdomyolysis, suppression of growth

Suppression of growth has been reported with long-term use of stimulants in children.

Nervous system

Frequency not reported: Dizziness, tremor, headache, exacerbation of Tourette's syndrome, unpleasant taste


Psychotic episodes have been rarely reported at recommended doses.

Rare (0.01% to 0.1%): Psychotic episodes

Frequency not reported: Dysphoria, overstimulation, euphoria, insomnia, restlessness, exacerbation of motor tics, exacerbation of verbal tics, changes in libido

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.